Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Glenn E. Kirsch"'
Autor:
Abby Sewell, Glenn E. Kirsch, Caiyun Wu, Arianne L. Motter, Fedorov Nikolai, Yuri A. Kuryshev, Lucas C. Armstrong, Michael S. Orr, Zhiqi Liu, Carmine Leggett
Publikováno v:
Slas Discovery
Nicotine, the addictive component of tobacco products, is an agonist at nicotinic acetylcholine receptors (nAChRs) in the brain. The subtypes of nAChR are defined by their α- and β-subunit composition. The α6β2β3 nAChR subtype is expressed in te
Autor:
Lucas C. Armstrong, Zhiqi Liu, Glenn E. Kirsch, Fedorov Nikolai, Yuri A. Kuryshev, Michael S. Orr
Publikováno v:
Assay and Drug Development Technologies
The Family Smoking Prevention and Tobacco Control Act of 2009 (Public Law 111-31) gave the US Food and Drug Administration (FDA) the responsibility for regulating tobacco products. Nicotine is the primary addictive component of tobacco and its effect
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 61:277-286
Introduction The cardiac action potential (CAP) of stem cell-derived human cardiomyocytes (SC-hCMs) is potentially the most powerful preclinical biomarker for cardiac safety and efficacy in humans. Our experiments tested this hypothesis by examining
Autor:
Barbara A. Wible, Peter Hawryluk, Glenn E. Kirsch, Eckhard Ficker, Yuri A. Kuryshev, Arthur Brown
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 52:136-145
Direct block of I(Kr) by non-antiarrhythmic drugs (NARDs) is a major cause of QT prolongation and torsades de pointes (TdP), and has made the hERG potassium channel a major target of drug safety programs in cardiotoxicity. Block of hERG currents is n
Autor:
Barbara A. Wible, Sven Kathöfer, Johann Kiehn, Dierk Thomas, Eckhard Ficker, Hugo A. Katus, Eberhard P. Scholz, Christoph A. Karle, Bettina C. Hammerling, Glenn E. Kirsch, Volker A. W. Kreye, Anna-Britt Wimmer, Mary C. Kochan, Edgar Zitron, Kezhong Wu, Wolfgang Schoels
Publikováno v:
British Journal of Pharmacology. 142:485-494
1 The topoisomerase II inhibitor amsacrine is used in the treatment of acute myelogenous leukemia. Although most anticancer drugs are believed not to cause acquired long QT syndrome (LQTS), concerns have been raised by reports of QT interval prolonga
Publikováno v:
Circulation. 108:2704-2709
Background— T-wave alternans is due to alternation of membrane repolarization at the cellular level and is a risk factor for sudden cardiac death. Recently, a hysteresis effect has been reported in patients whereby T-wave alternans, once induced by
Publikováno v:
Assay and Drug Development Technologies
Voltage-gated Ca2+ channels play essential roles in control of neurosecretion and muscle contraction. The pharmacological significance of Cav channels stem from their identification as the molecular targets of calcium blockers used in the treatment o
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 280:H354-H360
Idiopathic ventricular fibrillation (IVF) can cause sudden death in both adults and children. One form of IVF (Brugada syndrome), characterized by S-T segment elevation (STE) in the electrocardiogram, has been linked to mutations of SCN5A, the gene e
Publikováno v:
American Journal of Physiology-Cell Physiology. 274:C1501-C1510
We have determined the effects of coexpression of Kv2.1 with electrically silent Kv5.1 or Kv6.1 α-subunits in Xenopus oocytes on channel gating. Kv2.1/5.1 selectively accelerated the rate of inactivation at intermediate potentials (−30 to 0 mV), w
Autor:
Angel Moya, Charles Antzelevitch, Qiuyun Chen, Ramon Brugada, Qing Wang, Eric Schulze-Bahr, Jeffrey A. Towbin, Rocio Ortiz-Lopez, Martin Borggrefe, Josep Brugada, Glenn E. Kirsch, Mark T. Keating, Domenico Potenza, Richard E. O'Brien, Pedro Brugada, Zhiqing Wang, Günter Breithardt, Danmei Zhang
Publikováno v:
Nature
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Ventricular fibrillation causes more than 300,000 sudden deaths each year in the USA alone. In approximately 5-12% of these cases, there are no demonstrable cardiac or non-cardiac causes to account for the episode, which is therefore classified as id