Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Glenn C. Micalizio"'
Autor:
Lauren E. Markham, Thomas Koelblen, Harry R. Chobanian, Ariele Viacava Follis, Thomas P. Burris, Glenn C. Micalizio
Publikováno v:
ACS Central Science, Vol 10, Iss 2, Pp 477-486 (2024)
Externí odkaz:
https://doaj.org/article/bc3643e9ba394d348d4b01a951565274
Autor:
Wan Shin Kim, Zachary A. Shalit, Sidney M. Nguyen, Emmalie Schoepke, Alan Eastman, Thomas P. Burris, Arti B. Gaur, Glenn C. Micalizio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Many natural-product like drugs have a tetracyclic terpenoid core. Here, the authors developed a synthesis of triterpene-like tetracyclic systems, and apply this method to the preparation of a number of enantiomeric compounds, two of which are very s
Externí odkaz:
https://doaj.org/article/e48d05268db34d77806be736c82cc8ae
Autor:
HtooTint, Wai, Glenn C, Micalizio
Publikováno v:
The Journal of organic chemistry. 87(21)
Efforts to establish an asymmetric entry to hexanorlanostanes has resulted in a concise synthesis of 7,11-dideoxy-Δ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bdc9146c6576e45b5c36f2d70c10e6a
https://pubmed.ncbi.nlm.nih.gov/36206482
https://pubmed.ncbi.nlm.nih.gov/36206482
Autor:
HtooTint Wai, Glenn C. Micalizio
Publikováno v:
The Journal of Organic Chemistry. 87:14975-14979
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2423fe592f84e1b32be72b5747a597c3
https://doi.org/10.1021/acs.joc.2c02042
https://doi.org/10.1021/acs.joc.2c02042
Autor:
Adam B. Millham, Glenn C. Micalizio
Publikováno v:
Organic Letters. 24:7058-7061
In a program aimed at establishing a common sequence of C-C bond-forming reactions for asymmetric construction of tetracyclic triterpenoid natural products and related synthetic systems, effort has been directed toward introducing C17β-substitution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f7b02e0f58fba731d941c7225e488d
https://doi.org/10.1021/acs.orglett.2c02455
https://doi.org/10.1021/acs.orglett.2c02455
Autor:
Joshua M. Nicholson, Adam B. Millham, Andrea R. Bucknam, Lauren E. Markham, Xenia Ivanna Sailors, Glenn C. Micalizio
Publikováno v:
J Org Chem
Tetracyclic terpenoid-derived natural products are a broad class of medically relevant agents that include well-known steroid hormones and related structures, as well as more synthetically challenging congeners such as limonoids, cardenolides, lanost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75efab6d57bbf6ea118b35835f46a5b3
https://pubmed.ncbi.nlm.nih.gov/35175755
https://pubmed.ncbi.nlm.nih.gov/35175755
Publikováno v:
Org Lett
Progress toward an asymmetric synthesis of euphanes is described. A C14-desmethyl euphane system possessing five differentially substituted and electronically distinct alkenes has been prepared. The route employed is based on sequential metallacycle-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6380c65eadf3753eb1776c0049bb88
https://doi.org/10.1021/acs.orglett.2c01299
https://doi.org/10.1021/acs.orglett.2c01299
Asymmetric De Novo Synthesis of a Cucurbitane Triterpenoid: Total Synthesis of Octanorcucurbitacin B
Autor:
Andrea R. Bucknam, Glenn C. Micalizio
Publikováno v:
J Am Chem Soc
The asymmetric de novo synthesis of a cucurbitane natural product, octanorcucurbitacin B, has been accomplished. Cucurbitanes are a family of structurally complex triterpenoids that characteristically contain three stereodefined quaternary centers at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b246ba69e84011e7e2068d7bb46ded7c
https://doi.org/10.1021/jacs.2c03109
https://doi.org/10.1021/jacs.2c03109
Publikováno v:
Organic Letters. 23:2248-2252
The total synthesis of (+)-03219A, a rare Δ8,9-pregnene isolated from the marine-derived Streptomyces sp. SCSIO 03219, is described that is based on a series of transformations that enable progression from epichlorohydrin to an ent-estrane, then con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85ec585efc82b3b9ece558ef62d09486
https://doi.org/10.1021/acs.orglett.1c00382
https://doi.org/10.1021/acs.orglett.1c00382
Publikováno v:
Org Lett
While semisynthesis is a common platform for medicinal investigation of steroidal systems, varying the nature of substitution and stereochemistry at C9 and C10 remains challenging. It is demonstrated here that de novo synthesis, enabled by a metallac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fce0291fbf805d5bb4cc16fec30f1d
https://doi.org/10.1021/acs.orglett.0c02358
https://doi.org/10.1021/acs.orglett.0c02358