Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Glenn C. Capodagli"'
Autor:
Ana C. Puhl, Thomas R. Lane, Patricia A. Vignaux, Kimberley M. Zorn, Glenn C. Capodagli, Matthew B. Neiditch, Joel S. Freundlich, Sean Ekins
Publikováno v:
ACS Omega, Vol 5, Iss 46, Pp 29935-29942 (2020)
Externí odkaz:
https://doaj.org/article/bff690ac52fc49b0a2d1da9820cf196f
Autor:
Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target. The X-ray crystal structure of the KasA-DG167 compl
Externí odkaz:
https://doaj.org/article/8d6c465583e4410c8afdd48c4a9a3287
Autor:
Matthew B. Neiditch, Patricia A Vignaux, Kimberley M. Zorn, Thomas J. Lane, Sean Ekins, Ana C. Puhl, Joel S. Freundlich, Glenn C. Capodagli
Publikováno v:
ACS Omega, Vol 5, Iss 46, Pp 29935-29942 (2020)
Tuberculosis is caused by Mycobacterium tuberculosis (Mtb) and is a deadly disease resulting in the deaths of approximately 1.5 million people with 10 million infections reported in 2018. Recently, a key condensation step in the synthesis of mycolic
Autor:
Jason T. Kaelber, Matthew B. Neiditch, Kaitlyn M. Tylor, Michael J. Federle, Glenn C. Capodagli, Vasileios I. Petrou
Publikováno v:
Proc Natl Acad Sci U S A
Regulator gene of glucosyltransferase (Rgg) family proteins, such as Rgg2 and Rgg3, have emerged as primary quorum-sensing regulated transcription factors in Streptococcus species, controlling virulence, antimicrobial resistance, and biofilm formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6522c722c6e148533763a483b88216
https://europepmc.org/articles/PMC7533842/
https://europepmc.org/articles/PMC7533842/
Autor:
Matthew B. Neiditch, Michael J. Federle, Reid V. Wilkening, Glenn C. Capodagli, Atul Khataokar, Kaitlyn M. Tylor
Publikováno v:
Journal of Biological Chemistry. 292:20544-20557
Rap/Rgg/NprR/PlcR/PrgX (RRNPP) quorum-sensing systems use extracellular peptide pheromones that are detected by cytoplasmic receptors to regulate gene expression in firmicute bacteria. Rgg-type receptors are allosterically regulated through direct ph
Publikováno v:
Annual Review of Genetics. 51:311-333
Bacteria use diffusible chemical messengers, termed pheromones, to coordinate gene expression and behavior among cells in a community by a process known as quorum sensing. Pheromones of many gram-positive bacteria, such as Bacillus and Streptococcus,
Autor:
Xin Wang, Liping Li, Paridhi Sukheja, David Alland, Kholiswa Tsotetsi, Hsin Pin Ho Liang, David S. Perlin, Véronique Dartois, Todd Richmann, Courtney Grady, Glenn C. Capodagli, Matthew B. Neiditch, Riju Shrestha, Pradeep Kumar, Nancy D. Connell, Joel S. Freundlich, Ravindra Jadhav, Matthew D. Zimmerman, Marizel Mina, Steven Park, Riccardo Russo, Shao-Gang Li, Yong Mo Ahn, Daigo Inoyama, Divya Awasthi
Publikováno v:
Cell Chem Biol
Summary Published Mycobacterium tuberculosis β-ketoacyl-ACP synthase KasA inhibitors lack sufficient potency and/or pharmacokinetic properties. A structure-based approach was used to optimize existing KasA inhibitor DG167. This afforded indazole JSF
Autor:
Riju Shrestha, Matthew D. Zimmerman, Karishma Maharaja, Padmini Salgame, Divya Awasthi, Joel S. Freundlich, Glenn C. Capodagli, Aditi Gupta, David Alland, Hsin Pin Ho Liang, Alexander L. Perryman, Gene Porter, Riccardo Russo, Gautam Agnihotri, Roxanne Morris, Véronique Dartois, Marizel Mina, Sean Ekins, Sheetal Verma, Daigo Inoyama, Kyu Y. Rhee, Paridhi Sukheja, Patricia Soteropoulos, George Rasic, Jansy Sarathy, Todd Richmann, Zhe Wang, Nancy D. Connell, Eric Singleton, Matthew B. Neiditch, Seema Husain, Pradeep Kumar, Shao-Gang Li
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e02101-17 (2018)
mBio
mBio, Vol 9, Iss 6, p e02101-17 (2018)
mBio
Cell wall biosynthesis inhibitors have proven highly effective for treating tuberculosis (TB). We discovered and validated members of the indazole sulfonamide class of small molecules as inhibitors of Mycobacterium tuberculosis KasA—a key component
Autor:
Nancy G. Isern, Glenn C. Capodagli, Scott D. Pegan, Fengli Zhang, Michael J. Holliday, Elan Z. Eisenmesser, Geoffrey S. Armstrong
Publikováno v:
Protein Science. 24:651-660
Crimean-Congo Hemorrhagic fever virus (CCHFV) is one of several lethal viruses that encodes for a viral ovarian tumor domain (vOTU), which serves to cleave and remove ubiquitin (Ub) and interferon stimulated gene product 15 (ISG15) from numerous prot
Publikováno v:
Biochemistry
Staphylococcus aureus is one of the most common nosocomial sources of soft-tissue and skin infections and has more recently become prevalent in the community setting as well. Since the use of penicillins to combat S. aureus infections in the 1940s, t