Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Glenn C Rowe"'
Autor:
Chris McDermott-Roe, Marion Leleu, Glenn C Rowe, Oleg Palygin, John D Bukowy, Judy Kuo, Monika Rech, Steffie Hermans-Beijnsberger, Sebastian Schaefer, Eleonora Adami, Esther E Creemers, Matthias Heinig, Blanche Schroen, Zoltan Arany, Enrico Petretto, Aron M Geurts
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170458 (2017)
Mitochondrial dysfunction contributes to myriad monogenic and complex pathologies. To understand the underlying mechanisms, it is essential to define the full complement of proteins that modulate mitochondrial function. To identify such proteins, we
Externí odkaz:
https://doaj.org/article/32ee4dc91d374bd4874942d7b45e8553
Autor:
Sean Mendez, Louis Watanabe, Rachel Hill, Meredith Owens, Jason Moraczewski, Glenn C Rowe, Nicole C Riddle, Laura K Reed
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164706 (2016)
Obesity is one of the dramatic health issues affecting developed and developing nations, and exercise is a well-established intervention strategy. While exercise-by-genotype interactions have been shown in humans, overall little is known. Using the n
Externí odkaz:
https://doaj.org/article/27a94ee756664d2b8700c3a46e43d2be
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41817 (2012)
Exercise confers numerous health benefits, many of which are thought to stem from exercise-induced mitochondrial biogenesis (EIMB) in skeletal muscle. The transcriptional coactivator PGC-1α, a potent regulator of metabolism in numerous tissues, is w
Externí odkaz:
https://doaj.org/article/47ecbe01ee004502b35651725e090b37
Autor:
Lihao He, Yuxin Chu, Jing Yang, Jin He, Yutao Hua, Yunxi Chen, Gloria Benavides, Glenn C. Rowe, Lufang Zhou, Scott Ballinger, Victor Darley-Usmar, Martin E. Young, Sumanth D. Prabhu, Palaniappan Sethu, Yingling Zhou, Cheng Zhang, Min Xie
Publikováno v:
Cells, Vol 11, Iss 13, p 2111 (2022)
Reperfusion injury after extended ischemia accounts for approximately 50% of myocardial infarct size, and there is no standard therapy. HDAC inhibition reduces infarct size and enhances cardiomyocyte autophagy and PGC1α-mediated mitochondrial biogen
Externí odkaz:
https://doaj.org/article/ef5e42cac2a049f384d481f8b40da293
Autor:
Drue Benefield, Yazeed Abdelmageed, Jahmel Fowler, Serenah Smith, Kassandra Arias-Parbul, Courtney Dunning, Glenn C. Rowe
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R470-R479
The peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) family of transcriptional coactivators are regulators of mitochondrial oxidative capacity and content in skeletal muscle. Many of these conclusions are based primarily on gain-of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9457dddbb3f114ada4fb46cb27101c
https://doi.org/10.1152/ajpregu.00241.2022
https://doi.org/10.1152/ajpregu.00241.2022
Autor:
Lei Chen, Saumya Das, Haifei Tang, Rui Chen, Yan Yu, Junjie Xiao, Tingting Yang, Glenn C. Rowe, Jin Li, Zhao Sha
Publikováno v:
Mol Ther
Muscle atrophy is associated with negative outcomes in a variety of diseases. Identification of a common therapeutic target would address a significant unmet clinical need. Here, we identify a long non-coding RNA (lncRNA) (muscle-atrophy-associated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37aad4728d26efa726329b3c376b170
https://doi.org/10.1016/j.ymthe.2020.12.002
https://doi.org/10.1016/j.ymthe.2020.12.002
Autor:
Sonja Tweeten, Jin He, Lufang Zhou, Martin E. Young, Mahmoud Ismail, Fanfang Zeng, Min Xie, Glenn C. Rowe, Scott W. Ballinger, Jing Yang, Jianyi Zhang, Ling Gao, Sumanth D. Prabhu
Publikováno v:
J Mol Cell Cardiol
Aims The FDA-approved histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA, Vorinostat) has been shown to induce cardiomyocyte autophagy and blunt ischemia/reperfusion (I/R) injury when administered at the time of reperfusion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f1be87678c0ba747575e5addbc1bc5
https://doi.org/10.1016/j.yjmcc.2019.03.008
https://doi.org/10.1016/j.yjmcc.2019.03.008
Autor:
Teayoun Kim, Martin E. Young, Cheryl Cero, Aaron M. Cypess, Kirk M. Habegger, Chad S. Hunter, Jessica Kepple, Yanping Liu, James W. Johnson, Glenn C. Rowe
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101284-(2021)
Molecular Metabolism, Vol 53, Iss, Pp 101284-(2021)
Objective Brown adipose tissue (BAT) is critical for thermogenesis and glucose/lipid homeostasis. Exploiting the energy uncoupling capacity of BAT may reveal targets for obesity therapies. This exploitation requires a greater understanding of the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c86739156dfe134c95747fb78c9d776
https://pubmed.ncbi.nlm.nih.gov/34198011
https://pubmed.ncbi.nlm.nih.gov/34198011
Autor:
Sandeep Raha, Bart P. Hettinga, Tomas A. Prolla, Adam P. W. Johnston, Yevgenya Kratysberg, Imtiaz A. Samjoo, Adeel Safdar, James M. Flynn, Ayesha Saleem, Glenn C. Rowe, Mark A. Tarnopolsky, Yu Kitaoka, Konstantin Khrapko, Daniel I. Ogborn, Zoltan Arany, Michael De Lisio, Jonathan P. Little, Gianni Parise, Mahmood Akhtar
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-1 (2021)
Skeletal Muscle
Skeletal Muscle
Human genetic disorders and transgenic mouse models have shown that mitochondrial DNA (mtDNA) mutations and telomere dysfunction instigate the aging process. Epidemiologically, exercise is associated with greater life expectancy and reduced risk of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5807d0a35f2c4fa8f7e0fbe149dff15
https://doi.org/10.1186/s13395-021-00264-7
https://doi.org/10.1186/s13395-021-00264-7
Autor:
Sunil Sudarshan, Yawen Tang, Tanecia Mitchell, Glenn C. Rowe, Sandeep B. Shelar, Garrett J. Brinkley, Hyeyoung Nam, Shi Wei, Darshan S. Chandrashekar, Richard Kirkman, Sooryanarayana Varambally, Suman Karki, Phillip Buckhaults, Anirban Kundu, Carolina B. Livi
Publikováno v:
The Journal of Experimental Medicine
The transcription factor PRDM16 is epigenetically silenced in kidney cancer. Loss of this factor’s repressive properties promotes HIF-mediated induction of the protumorigenic factor SEMA5B. These data provide a novel epigenetic mechanism by which H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a6342289cc7e2ffbdef8c7374f23c3
https://doi.org/10.1084/jem.20191005
https://doi.org/10.1084/jem.20191005