Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Glenn A. MacLean"'
Autor:
Glenn A. MacLean, Jennifer McEldoon, Jialiang Huang, Jeremy Allred, Matthew C. Canver, Stuart. H. Orkin
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Individuals with Trisomy 21 (T21) exhibit numerous hematological abnormalities, including reductions in numbers of circulating B and T lymphocytes. To elucidate molecular mechanisms underlying these phenotypes, we differentiated human isogen
Externí odkaz:
https://doaj.org/article/c790d5a27e354f7cbec740145b8e1ef2
Autor:
Glenn A. MacLean, Tobias Cantz, Brigitte Schlegelberger, Jan-Henning Klusmann, Dirk Heckl, Gudrun Göhring, Nico Lachmann, Axel Schambach, Stephan Emmrich, Stuart H. Orkin, Erik Pittermann, Karl Welte, Mania Ackermann
Publikováno v:
Blood Advances. 1:903-914
Severe congenital neutropenia (SCN, Kostmann disease) is a heritable disorder characterized by a granulocytic maturation arrest. Biallelic mutations in HCLS1 associated protein X-1 (HAX1) are frequently detected in affected individuals, including tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2849e53596ce944f08fd16e39f506c1c
https://doi.org/10.1182/bloodadvances.2016003798
https://doi.org/10.1182/bloodadvances.2016003798
Autor:
Matthew C. Canver, Jeremy Allred, Stuart H. Orkin, Jennifer L. McEldoon, Glenn A. MacLean, Jialiang Huang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Individuals with Trisomy 21 (T21) exhibit numerous hematological abnormalities, including reductions in numbers of circulating B and T lymphocytes. To elucidate molecular mechanisms underlying these phenotypes, we differentiated human isogenic disomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5585b6b9733e5ea8e1a1fae37b9d2afb
https://doi.org/10.1038/s41598-018-26123-y
https://doi.org/10.1038/s41598-018-26123-y
Autor:
Yuko Fujiwara, Glenn A. MacLean, Leonard I. Zon, Pavankumar N. G. Reddy, Dietmar Vestweber, Kathleen A. Soltis, Dhvanit I. Shah, Taylor C. Patch, Kathleen Hübner, Daniel E. Bauer, Heidi Anderson, Maike Frye, George Q. Daley, Nicholas C. Huston, John P. Kanki, Owen J. Tamplin, Elliott J. Hagedorn, Barry H. Paw, Peter Geon Kim, Minh Nguyen, Stuart H. Orkin, Guillaume Vogin, Michael J. Chen
Rare endothelial cells in the aorta-gonad-mesonephros (AGM) transition into hematopoietic stem cells (HSCs) during embryonic development. Lineage tracing experiments indicate that HSCs emerge from cadherin 5 (Cdh5; vascular endothelial-cadherin)(+) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477a450c8778a6a07e1fb5e81bcb25da
https://europepmc.org/articles/PMC4692141/
https://europepmc.org/articles/PMC4692141/
Publikováno v:
Thrombosis and Haemostasis. 86:909-913
SummaryWe compare the relative activities of surface-bound and fluid-phase thrombin and their inhibition by heparin and Intimatan, a novel heparin cofactor II (HCII) agonist. In vitro, we compared the observed amidolytic activities of fluid-phase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::531763a725c867bcb3b07839e5da0fe9
https://doi.org/10.1055/s-0037-1616149
https://doi.org/10.1055/s-0037-1616149
Autor:
In-Hyun Park, Stuart H. Orkin, Glenn A. MacLean, Guoji Guo, Danielle J. Sanchez, George Q. Daley, Tobias F. Menne
Trisomy 21 is associated with hematopoietic abnormalities in the fetal liver, a preleukemic condition termed transient myeloproliferative disorder, and increased incidence of acute megakaryoblastic leukemia. Human trisomy 21 pluripotent cells of vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183bcb859f0fa4299d038239d961918b
https://europepmc.org/articles/PMC3491455/
https://europepmc.org/articles/PMC3491455/
Autor:
Yichen Shi, Frederick J. Livesey, James Smith, Peter Kirwan, Glenn A. MacLean, Stuart H. Orkin
Publikováno v:
Science Translational Medicine. 4
Human cellular models of Alzheimer’s disease (AD) pathogenesis would enable the investigation of candidate pathogenic mechanisms in AD and the testing and developing of new therapeutic strategies. We report the development of AD pathologies in cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93872ff8a31c152d67e85ba392a7e41
https://doi.org/10.1126/scitranslmed.3003771
https://doi.org/10.1126/scitranslmed.3003771
Autor:
Tracie, Pennimpede, Don A, Cameron, Glenn A, MacLean, Hui, Li, Suzan, Abu-Abed, Martin, Petkovich
Publikováno v:
Birth defects research. Part A, Clinical and molecular teratology. 88(10)
Retinoic acid (RA) is a pleiotropic derivative of vitamin A, or retinol, which is responsible for all of the bioactivity associated with this vitamin. The teratogenic influences of vitamin A deficiency and excess RA in rodents were first observed mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::014c691d2de2622e90dd2db9626a1f49
https://pubmed.ncbi.nlm.nih.gov/20842651
https://pubmed.ncbi.nlm.nih.gov/20842651