Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Glenn A, McConkey"'
Autor:
Ellen Tedford, Norhidayah Binti Badya, Conor Laing, Nozomi Asaoka, Shuji Kaneko, Beatrice Maria Filippi, Glenn Alan McConkey
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Infection with the protozoan Toxoplasma gondii induces changes in neurotransmission, neuroinflammation, and behavior, yet it remains elusive how these changes come about. In this study we investigated how norepinephrine levels are altered by
Externí odkaz:
https://doaj.org/article/6477603b1f3c44a6ba30dd54c220a8dc
Manipulation of neural stem cell proliferation and differentiation in the postnatal CNS is receiving significant attention due to therapeutic potential. In the spinal cord, such manipulations may promote repair in conditions such as multiple sclerosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd620b20e8fa3cf69849465eafcdf5a
https://doi.org/10.1101/2022.04.21.489053
https://doi.org/10.1101/2022.04.21.489053
Autor:
Jitender P Dubey, Leandra R Ferreira, Mohammad Alsaad, Shiv K Verma, Derron A Alves, Gary N Holland, Glenn A McConkey
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156255 (2016)
BACKGROUND:The protozoan parasite Toxoplasma gondii is one of the most widely distributed and successful parasites. Toxoplasma gondii alters rodent behavior such that infected rodents reverse their fear of cat odor, and indeed are attracted rather th
Externí odkaz:
https://doaj.org/article/d759216a16904736a5cc6a591cd9bc1a
Autor:
Marion Bonnet, Alison Cave, Matthias P Hofer, Glenn A McConkey, Nicholas Medcalf, Stephen P Smith, Teresa Tsakok, Robert Watson, Steve Webster, Tao You
The UK COVID-19 Therapeutics Advisory Panel was convened to review and select potential COVID-19 therapeutics for publicly funded clinical trials. Briefs were prepared by the UKRI Secretariat Due Diligence Team to support the work of the Panel. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91af89bd557d6b16d13c04c8e442ec45
Autor:
Patrick F. Chinnery, Marion Bonnet, Alison Cave, Matthias P. Hofer, Alastair Lamb, Glenn A. McConkey, Nicholas Medcalf, Stephen P. Smith, Teresa Tsakok, Robert Watson, Steve Webster, Tao You
In 2020, the UK government funded a portfolio of platform trials to develop new treatments for COVID-19. A key feature was the independent prioritization of candidate drugs with central coordination to prevent duplication, accelerating recruitment to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52666a5d7f26cfa0002f94cf21658ab
Publikováno v:
Trends in Immunology
Trends in Immunology, Elsevier, 2020, 41, pp.1072-1082. ⟨10.1016/j.it.2020.10.001⟩
Trends in Immunology, 2020, 41, pp.1072-1082. ⟨10.1016/j.it.2020.10.001⟩
Trends in Immunology, Elsevier, 2020, 41, pp.1072-1082. ⟨10.1016/j.it.2020.10.001⟩
Trends in Immunology, 2020, 41, pp.1072-1082. ⟨10.1016/j.it.2020.10.001⟩
International audience; Infections of the nervous system elicit neuroimmune responses and alter neurotransmission, affecting host neurological functions. Chronic infection with the apicomplexan parasite Toxoplasma correlates with certain neurological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56152d499efb59d81ade4aac88f4ae39
https://hal.archives-ouvertes.fr/hal-03493524
https://hal.archives-ouvertes.fr/hal-03493524
Autor:
Beatrice M. Filippi, Conor Laing, Ellen Tedford, Glenn A. McConkey, Nozomi Asaoka, Norhidayah Binti Badya, Shuji Kaneko
Infection with the protozoan Toxoplasma gondii induces changes in neurotransmission, neuroinflammation, and behavior. Yet, it remains elusive how these changes are wrought by the small percentage of neurons that are infected. In this study we investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c6c953e94433f453cd64f3eac5843d
https://doi.org/10.1101/2020.11.26.399345
https://doi.org/10.1101/2020.11.26.399345
Autor:
Emese Prandovszky, Elizabeth Gaskell, Heather Martin, J P Dubey, Joanne P Webster, Glenn A McConkey
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23866 (2011)
The highly prevalent parasite Toxoplasma gondii manipulates its host's behavior. In infected rodents, the behavioral changes increase the likelihood that the parasite will be transmitted back to its definitive cat host, an essential step in completio
Externí odkaz:
https://doaj.org/article/9270baa737ea4c36904fe15b558f9256
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4801 (2009)
The genome of the protozoan parasite Toxoplasma gondii was found to contain two genes encoding tyrosine hydroxylase; that produces L-DOPA. The encoded enzymes metabolize phenylalanine as well as tyrosine with substrate preference for tyrosine. Thus t
Externí odkaz:
https://doaj.org/article/23a920e4401849d9831e1872affd2616
Autor:
David R. Burrell, Nicholas C. Chambers, Fraser Cunningham, Timothy J. Prior, Andrew N. Boa, Colin W. G. Fishwick, Glenn A. McConkey, Paul T. P. Bedingfield
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3878-3882
Two new tricyclic β-aminoacrylate derivatives (2e and 3e) have been found to be inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with Ki 0.037 and 0.15 μM respectively. 1H and 13C NMR spectroscopic data show that these com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69da95e39487b4467a7f45970f6a0dc2
https://doi.org/10.1016/j.bmcl.2017.06.052
https://doi.org/10.1016/j.bmcl.2017.06.052