Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Glenn, Goetgeluk"'
Autor:
Melissa Pille, John Avila, Guillem Sanchez Sanchez, Glenn Goetgeluk, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Joline Ingels, Laurenz De Cock, Eva Pascal, Lucas Deseins, Tessa Kerre, Tom Taghon, Georges Leclercq, David Vermijlen, Brian Davis, Bart Vandekerckhove
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections
Externí odkaz:
https://doaj.org/article/8e328ea3407848819b605b95f452cf7f
Autor:
Laurens Raes, Melissa Pille, Aranit Harizaj, Glenn Goetgeluk, Jelter Van Hoeck, Stephan Stremersch, Juan C. Fraire, Toon Brans, Olivier Gerrit de Jong, Roel Maas-Bakker, Enrico Mastrobattista, Pieter Vader, Stefaan C. De Smedt, Bart Vandekerckhove, Koen Raemdonck, Kevin Braeckmans
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 696-707 (2021)
The CRISPR-Cas9 technology represents a powerful tool for genome engineering in eukaryotic cells, advancing both fundamental research and therapeutic strategies. Despite the enormous potential of the technology, efficient and direct intracellular del
Externí odkaz:
https://doaj.org/article/d83a80530b204562bf8701e1aa7bfddd
Autor:
Laurens Raes, Stephan Stremersch, Juan C. Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, Xavier Saelens, Bart Vandekerckhove, Stefaan De Smedt, Koen Raemdonck, Kevin Braeckmans
Publikováno v:
Nano-Micro Letters, Vol 12, Iss 1, Pp 1-17 (2020)
Abstract Efficient and safe cell engineering by transfection of nucleic acids remains one of the long-standing hurdles for fundamental biomedical research and many new therapeutic applications, such as CAR T cell-based therapies. mRNA has recently ga
Externí odkaz:
https://doaj.org/article/543a96ad06524b4f9271212ffb59401e
Autor:
Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms’ tumor 1 (WT1), a tumor-associated antigen overexpressed in several malignancies, including acute myeloid leukemia (AML). For both chimeric antigen receptor (CAR)-
Externí odkaz:
https://doaj.org/article/b8d37350b35e4c9e9ca7c2af1a96b344
Autor:
Barbara Depreter, Karin E. Weening, Karl Vandepoele, Magnus Essand, Barbara De Moerloose, Maria Themeli, Jacqueline Cloos, Diana Hanekamp, Ine Moors, Inge D’hont, Barbara Denys, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Sylvia Snauwaert, Glenn Goetgeluk, Stijn De Munter, Tessa Kerre, Bart Vandekerckhove, Tim Lammens, Jan Philippé
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Immunotherapeutic strategies targeting the rare leukemic stem cell compartment might provide salvage to the high relapse rates currently observed in acute myeloid leukemia (AML). We applied gene expression profiling for comparison of leukemic blasts
Externí odkaz:
https://doaj.org/article/fd108e28e0bd4466a0913f7a7117a0d5
Autor:
Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Chimeric antigen receptor (CAR) T-cells have shown great promise in the treatment of B-cell malignancies. For acute myeloid leukemia (AML), however, the optimal target surface antigen has yet to be discovered. Alternatively, T-cell receptor (TCR)-red
Externí odkaz:
https://doaj.org/article/8a9e6e8dd9154340bb2f53f8c0e0027b
Autor:
Stijn De Munter, Juliane Buhl, Laurenz De Cock, Alexander Van Parys, Willem Daneels, Eva Pascal, Lucas Deseins, Joline Ingels, Glenn Goetgeluk, Lore Billiet, Melissa Pille, Niels Vandamme, Jo Van Dorpe, Fritz Offner, Erik Depla, Jan Tavernier, Tessa Kerre, Jarno Drost, Bart Vandekerckhove
CD70 is an attractive target for chimeric antigen receptor (CAR) T cell therapy as treatment for both solid and liquid malignancies. However, functionality of CD70-specific CARs is only modest. Here, we optimized a CD70-specific VHH based CAR (nanoCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e90292e5574b0d0e1648efcade88f4e
https://doi.org/10.1101/2023.01.22.523482
https://doi.org/10.1101/2023.01.22.523482
Autor:
Dominika Berdecka, Aranit Harizaj, Ilia Goemaere, Deep Punj, Glenn Goetgeluk, Stijn De Munter, Herlinde De Keersmaecker, Veerle Boterberg, Peter Dubruel, Bart Vandekerckhove, Stefaan C. De Smedt, Winnok H. De Vos, Kevin Braeckmans
Publikováno v:
Journal of controlled release
Ex vivo modification of T cells with exogenous cargo is a common prerequisite for the development of T cell therapies, such as chimeric antigen receptor therapy. Despite the clinical success and FDA approval of several such products, T cell manufactu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fda67e27d25df735f29d39c4138aef
https://hdl.handle.net/10067/1940840151162165141
https://hdl.handle.net/10067/1940840151162165141
Autor:
Lore Billiet, Laurenz De Cock, Guillem Sanchez Sanchez, Rupert L. Mayer, Glenn Goetgeluk, Stijn De Munter, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Eva Pascal, Killian Raes, Sarah Bonte, Tessa Kerre, Niels Vandamme, Ruth Seurinck, Jana Roels, Marieke Lavaert, Filip Van Nieuwerburgh, Georges Leclercq, Tom Taghon, Francis Impens, Björn Menten, David Vermijlen, Bart Vandekerckhove
Publikováno v:
JOURNAL OF EXPERIMENTAL MEDICINE
Billiet et al. identify the post-thymic progeny of the agonist-selected CD10(+) PD-1(+) precursors in humans based on shared characteristics of the T cell receptor repertoire and the transcriptome. This lineage represents a well-defined but heterogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb2709fc96a8b395ba17769f1460ee0
https://biblio.ugent.be/publication/01H32AFRDVK3SC2WQW4NA0DG5Z/file/01H32AGM1QN46XV5BFJWVGT2X3
https://biblio.ugent.be/publication/01H32AFRDVK3SC2WQW4NA0DG5Z/file/01H32AGM1QN46XV5BFJWVGT2X3
Autor:
Yasmine Van Caeneghem, Stijn De Munter, Paola Tieppo, Glenn Goetgeluk, Karin Weening, Greet Verstichel, Sarah Bonte, Tom Taghon, Georges Leclercq, Tessa Kerre, Reno Debets, David Vermijlen, Hinrich Abken, Bart Vandekerckhove
Publikováno v:
OncoImmunology, Vol 6, Iss 3 (2017)
Recent clinical studies indicate that adoptive T-cell therapy and especially chimeric antigen receptor (CAR) T-cell therapy is a very potent and potentially curative treatment for B-lineage hematologic malignancies. Currently, autologous peripheral b
Externí odkaz:
https://doaj.org/article/20e75ad2cb564c7c8a949cd5e8b92798