Výsledky vyhledávání - "Glen S. Germain"

Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice

Autor: Najat C. Daw, Clinton F. Stewart, Franklin C. Harwood, Jesse J. Jenkins, Richard J. Gilbertson, Markos Leggas, Pamela J. Cheshire, John D. Schuetz, John C. Panetta, Peter J. Houghton, Jennifer K. Peterson, Glen S. Germain

Publikováno v: Cancer Research. 64:7491-7499

As a single agent the ERBB1 inhibitor, gefitinib (Iressa; ZD1839) showed minimal activity against a panel of 10 pediatric tumor xenografts that do not express the ERBB1 receptor. However, combined with irinotecan (CPT-11), significantly greater than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a8f647aa07e1efe3d9d49fbfc24abe
https://doi.org/10.1158/0008-5472.can-04-0096

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Inhibition of Mammalian Target of Rapamycin Activates Apoptosis Signal-regulating Kinase 1 Signaling by Suppressing Protein Phosphatase 5 Activity

Autor: Glen S. Germain, Shile Huang, Hidenori Ichijo, Franklin C. Harwood, John Easton, Peter J. Houghton, Lili Shu

Publikováno v: Journal of Biological Chemistry. 279:36490-36496

Under serum-free conditions, rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), induces a cellular stress response characterized by rapid and sustained activation of the apoptosis signal-regulating kinase 1 (ASK1) signaling pathway and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539b5b7989f005673f656f1f6d70754a
https://doi.org/10.1074/jbc.m401208200

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Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

Autor: Peter J. Houghton, Peter Traxler, Glen S. Germain, Clinton F. Stewart, Franklin C. Harwood, John D. Schuetz, Elisabeth Buchdunger

Publikováno v: Cancer Research. 64:2333-2337

Imatinib mesylate (Gleevec, STI571) is a kinase inhibitor selective for Bcr-Abl, activated c-Kit kinases, and platelet-derived growth factor receptor tyrosine kinase. Imatinib mesylate, similar to many other tyrosine kinase inhibitors (TKIs), such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec284a127f721c2aa06a4b68e594522
https://doi.org/10.1158/0008-5472.can-03-3344

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The influence of recombinant human insulin-like growth factor-I (rhIGF-I) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and xenograft models

Autor: Corrie E.M. Gidding, Glen S. Germain, Michael B. Dilling, Tiny G. J. Meeuwsen-de Boer, Richard A. Ashmun, Siebold S. N. de Graaf, Karen A. Veverka, Willem A. Kamps, Peter J. Houghton

Publikováno v: Cancer Chemotherapy and Pharmacology, 45, 1, pp. 21-30
Cancer Chemotherapy and Pharmacology, 45, 21-30

Purpose: Recombinant human insulin-like growth factor I (rhIGF-I) has been reported to ameliorate vincristine-induced neuropathy, the dose-limiting side effect of this antimitotic anticancer drug. However, rhIGF-I also might have adverse effects, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e9bd44d3ea68796cf676d5108bba51
https://hdl.handle.net/2066/184670

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Characterization of a Novel Bisacridone and Comparison with PSC 833 as a Potent and Poorly Reversible Modulator of P-Glycoprotein

Autor: Julie K. Horton, Ariel F. Castro, Guillermo A. Altenberg, Peter J. Houghton, Kuntebommanahalli N. Thimmaiah, Glen S. Germain, G. Krishne Gowda

Publikováno v: Molecular Pharmacology. 52:948-957

Novel compounds, composed of two acridone moieties connected by a propyl or butyl spacer, were synthesized and tested as potential modulators of P-glycoprotein (P-gp)-mediated multidrug resistance. The propyl derivative 1,3-bis(9-oxoacridin-10-yl)-pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fed08c078b6fe34fb2d5d2d4d6d6bb3
https://doi.org/10.1124/mol.52.6.948

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Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency

Autor: Glen S. Germain, Janet A. Houghton, Saeed Radparvar, Peter J. Houghton, Atiqur Rahman, Janet W. Pennington

Publikováno v: Biochemical Pharmacology. 39:1759-1765

A human colon adenocarcinoma cell line (GC3TK-) was selected for thymidine kinase (TK) deficiency from cloned parental cells (GC3C1) by exposure to 5-bromodeoxyuridine (BrdUrd). The cellular pharmacology of 5-fluorouracil (FUra) and the influence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724781af3870556ea546ead0646bb4be
https://doi.org/10.1016/0006-2952(90)90122-2

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Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling

Autor: Shantaram Kamath, Kuntebommanahalli N. Thimmaiah, Christopher L. Morton, John Easton, Peter J. Houghton, John K. Buolamwini, Glen S. Germain

Publikováno v: The Journal of biological chemistry. 280(36)

A series of 30 N10-substituted phenoxazines were synthesized and screened as potential inhibitors of Akt. In cellular assays at 5 mum, 17 compounds inhibited insulin-like growth factor 1 (IGF-I)-stimulated phosphorylation of Akt (Ser-473) by at least

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5684acd296cf06e1661e912be6f813f
https://pubmed.ncbi.nlm.nih.gov/16009706

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Analysis of three variable number terminal repeat loci is sufficient to characterize the deoxyribonucleic acid fingerprints of a panel of human tumor cell lines

Autor: Allyson L, Anding, Tanika, Reiss, Glen S, Germain

Publikováno v: In vitro cellulardevelopmental biology. Animal. 39(7)

Using primers for the MCT118, YNZ22, and COL2A1 loci in polymerase chain reaction analysis we could distinguish among the approximately 20 cell lines routinely maintained in our laboratory. We also demonstrated that the cell line NB-1691 (a neuroblas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10f723ba6abc344a616ed02e8e21b334
https://pubmed.ncbi.nlm.nih.gov/12964903

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Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways

Autor: Kuntebommanahalli N, Thimmaiah, John, Easton, Shile, Huang, Karen A, Veverka, Glen S, Germain, Franklin C, Harwood, Peter J, Houghton

Publikováno v: Cancer research. 63(2)

The mTOR inhibitor rapamycin induces G1 cell cycle accumulation and p53-independent apoptosis of the human rhabdomyosarcoma cell line Rh1. Insulin-like growth factor I (IGF-I) and insulin, but not epidermal growth factor or platelet-derived growth fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57a1617bcbbd9beec6bf265f6e436d18
https://pubmed.ncbi.nlm.nih.gov/12543789

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