Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Glen R. Van Loon"'
Nicotine is the major factor in the continuation of the smoking habit among humans. On December 2-4, 1985, under the sponsorship of the Tobacco and Health Research Institute in Lexington, Kentucky, leading scientists from around the world whose resea
Publikováno v:
Neuroscience Letters. 113:40-46
We have hypothesized that some effects of nicotine are mediated through endogenous opioids. This study was designed to demonstrate in rats that nicotine releases endogenous opioids in brain. In the control group, subcutaneous morphine (8 mg/kg) produ
Autor:
Abdulghani A. Houdi, Glen R. Van Loon
Publikováno v:
Journal of Neurochemistry. 54:1360-1366
A sensitive and specific radioimmunoassay has been developed for the tripeptide, Tyr-Gly-Gly, which has been shown previously to be an extraneuronal metabolite of opioid peptides derived from proenkephalin A. Using this assay, we found a regional var
Publikováno v:
Pharmacology, biochemistry, and behavior. 38(4)
Nicotine produces potent cardiovascular and sympathoadrenal effects. Furthermore, repeated administration of nicotine is associated with development of tolerance for many responses. We sought to compare the effects of initial intracerebral administra
Publikováno v:
Peptides. 12(1)
Nicotine acts in CNS, but the pathways and mechanisms of its action are poorly understood. Recent studies suggest an interaction between brain nicotinic receptors and endogenous opioid peptides. Acute administration of nicotine may alter enkephalin r
Publikováno v:
Life Sciences. 39:21-28
Methods of preventing the degradation of 3 H-methionine-enkephalin ( 3 H-ME) in human blood both at 37°C and under conditions of immediate cooling were examined. We found that, contrary to previous suggestions, use of aprotinin (with or without imme
Publikováno v:
Psychiatry Research. 19:87-92
The mode of action of lithium in the treatment of bipolar affective disorder is unknown. Among its actions are effects on release and response to catecholamines in experimental animals. We have therefore examined its effect on peripheral catecholamin
Publikováno v:
Brain Research Bulletin. 10:539-545
The role of PRL in mediating the haloperidol-induced increase in tuberoinfundibular dopamine synthesis rate was assessed by studying the effects of administration of PRL antiserum. Antiserum to PRL generated in rabbits and not cross-reacting with oth
Publikováno v:
Peptides. 8:1035-1043
The distribution of cryptic forms (larger enkephalin-containing peptides) in neostriatum, hypothalamus, spinal cord T3-L1 and neurointermediate lobe of pituitary were determined by radioimmunoassay. Optimal conditions for enzymic hydrolysis of the cr
Publikováno v:
Endocrinology. 109:46-53
Intracisternal administration of synthetic human beta-endorphin (0.058-7.25 nmol) in chronically cannulated, conscious, freely moving, adult male rats increased plasma concentrations of epinephrine, norepinephrine, and dopamine in a dose-related mann