Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Glen R. Monroe"'
Autor:
Christina Stangl, Sam de Blank, Ivo Renkens, Liset Westera, Tamara Verbeek, Jose Espejo Valle-Inclan, Rocio Chamorro González, Anton G. Henssen, Markus J. van Roosmalen, Ronald W. Stam, Emile E. Voest, Wigard P. Kloosterman, Gijs van Haaften, Glen R. Monroe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Fusion genes are a hallmarks of cancer, though breakpoint-position promiscuity restricts diagnostic detection. Here, the authors present FUDGE, a CRISPR-Cas9-based enrichment strategy for nanopore sequencing to identify target fusions irrespective of
Externí odkaz:
https://doaj.org/article/e33d69e505f647c4a248cf888947cfbb
Autor:
Lot Snijders Blok, Justine Rousseau, Joanna Twist, Sophie Ehresmann, Motoki Takaku, Hanka Venselaar, Lance H. Rodan, Catherine B. Nowak, Jessica Douglas, Kathryn J. Swoboda, Marcie A. Steeves, Inderneel Sahai, Connie T. R. M. Stumpel, Alexander P. A. Stegmann, Patricia Wheeler, Marcia Willing, Elise Fiala, Aaina Kochhar, William T. Gibson, Ana S. A. Cohen, Ruky Agbahovbe, A. Micheil Innes, P. Y. Billie Au, Julia Rankin, Ilse J. Anderson, Steven A. Skinner, Raymond J. Louie, Hannah E. Warren, Alexandra Afenjar, Boris Keren, Caroline Nava, Julien Buratti, Arnaud Isapof, Diana Rodriguez, Raymond Lewandowski, Jennifer Propst, Ton van Essen, Murim Choi, Sangmoon Lee, Jong H. Chae, Susan Price, Rhonda E. Schnur, Ganka Douglas, Ingrid M. Wentzensen, Christiane Zweier, André Reis, Martin G. Bialer, Christine Moore, Marije Koopmans, Eva H. Brilstra, Glen R. Monroe, Koen L. I. van Gassen, Ellen van Binsbergen, Ruth Newbury-Ecob, Lucy Bownass, Ingrid Bader, Johannes A. Mayr, Saskia B. Wortmann, Kathy J. Jakielski, Edythe A. Strand, Katja Kloth, Tatjana Bierhals, The DDD study, John D. Roberts, Robert M. Petrovich, Shinichi Machida, Hitoshi Kurumizaka, Stefan Lelieveld, Rolph Pfundt, Sandra Jansen, Pelagia Deriziotis, Laurence Faivre, Julien Thevenon, Mirna Assoum, Lawrence Shriberg, Tjitske Kleefstra, Han G. Brunner, Paul A. Wade, Simon E. Fisher, Philippe M. Campeau
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-4 (2019)
The HTML and PDF versions of this Article were updated after publication to remove images of one individual from Figure 1.
Externí odkaz:
https://doaj.org/article/360ad6a6ef7c4ee28aed4090b30bd7e5
Autor:
Glen R. Monroe, Albertien M. van Eerde, Federico Tessadori, Karen J. Duran, Sanne M. C. Savelberg, Johanna C. van Alfen, Paulien A. Terhal, Saskia N. van der Crabben, Klaske D. Lichtenbelt, Sabine A. Fuchs, Johan Gerrits, Markus J. van Roosmalen, Koen L. van Gassen, Mirjam van Aalderen, Bart G. Koot, Marlies Oostendorp, Marinus Duran, Gepke Visser, Tom J. de Koning, Francesco Calì, Paolo Bosco, Karin Geleijns, Monique G. M. de Sain-van der Velden, Nine V. Knoers, Jeroen Bakkers, Nanda M. Verhoeven-Duif, Gijs van Haaften, Judith J. Jans
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
D-lactic acidosis typically occurs in the context of short bowel syndrome; excess D-lactate is produced by intestinal bacteria. Here, the authors identify two point mutations in the human lactate dehydrogenase D (LDHD) gene that cause enzymatic loss
Externí odkaz:
https://doaj.org/article/0dc2cc8f517f49eaa57ea85a84853e50
Autor:
Lot Snijders Blok, Justine Rousseau, Joanna Twist, Sophie Ehresmann, Motoki Takaku, Hanka Venselaar, Lance H. Rodan, Catherine B. Nowak, Jessica Douglas, Kathryn J. Swoboda, Marcie A. Steeves, Inderneel Sahai, Connie T. R. M. Stumpel, Alexander P. A. Stegmann, Patricia Wheeler, Marcia Willing, Elise Fiala, Aaina Kochhar, William T. Gibson, Ana S. A. Cohen, Ruky Agbahovbe, A. Micheil Innes, P. Y. Billie Au, Julia Rankin, Ilse J. Anderson, Steven A. Skinner, Raymond J. Louie, Hannah E. Warren, Alexandra Afenjar, Boris Keren, Caroline Nava, Julien Buratti, Arnaud Isapof, Diana Rodriguez, Raymond Lewandowski, Jennifer Propst, Ton van Essen, Murim Choi, Sangmoon Lee, Jong H. Chae, Susan Price, Rhonda E. Schnur, Ganka Douglas, Ingrid M. Wentzensen, Christiane Zweier, André Reis, Martin G. Bialer, Christine Moore, Marije Koopmans, Eva H. Brilstra, Glen R. Monroe, Koen L. I. van Gassen, Ellen van Binsbergen, Ruth Newbury-Ecob, Lucy Bownass, Ingrid Bader, Johannes A. Mayr, Saskia B. Wortmann, Kathy J. Jakielski, Edythe A. Strand, Katja Kloth, Tatjana Bierhals, The DDD study, John D. Roberts, Robert M. Petrovich, Shinichi Machida, Hitoshi Kurumizaka, Stefan Lelieveld, Rolph Pfundt, Sandra Jansen, Pelagia Deriziotis, Laurence Faivre, Julien Thevenon, Mirna Assoum, Lawrence Shriberg, Tjitske Kleefstra, Han G. Brunner, Paul A. Wade, Simon E. Fisher, Philippe M. Campeau
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with
Externí odkaz:
https://doaj.org/article/2f149b8196854879821d3ece66218bf2
Autor:
Joline F. Roze, Joachim Kutzera, Wouter Koole, Margreet G. E. M. Ausems, Kristi Engelstad, Jurgen M. J. Piek, Cor D. de Kroon, René H. M. Verheijen, Gijs van Haaften, Ronald P. Zweemer, Glen R. Monroe
Publikováno v:
Cancers, Vol 13, Iss 10, p 2430 (2021)
Adult granulosa cell tumor (AGCT) is a rare ovarian cancer subtype, with a peak incidence around 50–55 years. Although AGCT can occur in specific syndromes, a genetic predisposition for AGCT has not been identified. The aim of this study is to iden
Externí odkaz:
https://doaj.org/article/7aa044918fa740179c8b6e6c26ab6e5d
Autor:
Xiaoyan Wu, Elise R. den Boer, Manon Vos-Loohuis, Frank G. van Steenbeek, Glen R. Monroe, Isaäc J. Nijman, Peter. A. J. Leegwater, Hille Fieten
Publikováno v:
Life, Vol 10, Iss 11, p 266 (2020)
Copper toxicosis is a complex genetic disorder in Labrador retrievers characterized by hepatic copper accumulation eventually leading to liver cirrhosis. The variation of hepatic copper levels in Labrador retrievers has been partly explained by mutat
Externí odkaz:
https://doaj.org/article/7463f400f0e144fda5e58b81dca5c295
Autor:
Glen R. Monroe, Hannah S. van Meurs, S. T. Paijens, Gijs van Haaften, Edith D.J. Peters, Ferdinando Sereno, Joline F. Roze, Hans W. Nijman, J. W. Groeneweg, Luc R.C.W. van Lonkhuijzen, Anna G.J. Brink, Ronald P. Zweemer, Jurgen M.J. Piek, Christianne A.R. Lok
Publikováno v:
Gynecologic oncology, 162(2), 413-420. Academic Press Inc.
Gynecologic Oncology, 162(2), 413-420. ACADEMIC PRESS INC ELSEVIER SCIENCE
Gynecologic Oncology, 162(2), 413-420. ACADEMIC PRESS INC ELSEVIER SCIENCE
OBJECTIVE: Adult granulosa cell tumors (aGCTs) represent a rare, hormonally active subtype of ovarian cancer that has a tendency to relapse late and repeatedly. Current serum hormone markers are inaccurate in reflecting tumor burden in a subset of aG
Autor:
Joline F. Roze, Petronella O. Witteveen, Luc R.C.W. van Lonkhuijzen, Hannah S. van Meurs, Wouter B. Veldhuis, Geertruida N. Jonges, Arthur J. A. T. Braat, Glen R. Monroe, Ronald P. Zweemer, J. W. Groeneweg, Roel J. Bennink
Publikováno v:
Oncotarget
Oncotarget, 12(7), 665-673. Impact Journals
Oncotarget, 12(7), 665-673. Impact Journals
Purpose Adult granulosa cell tumors (AGCTs) of the ovary represent a rare malignancy in which timing and choice of treatment is a clinical challenge. This study investigates the value of FDG-PET/CT and FES-PET/CT in monitoring recurrent AGCTs and ass
Autor:
Ineke Fransen, Murat Gultekin, Glen R. Monroe, René H.M. Verheijen, Joline F. Roze, J. W. Groeneweg, Ronald P. Zweemer
Publikováno v:
International Journal of Gynecologic Cancer. 30:2012-2014
Although patient engagement has become increasingly relevant, researchers find it difficult to involve patients, specifically in translational research. Particularly in rare disease research, patient engagement is crucial. First, since grant donors f
Autor:
S. T. Paijens, Hannah S. van Meurs, Elena Sendino Garví, Geertruida N. Jonges, Ronald P. Zweemer, Gijs van Haaften, J. W. Groeneweg, René H.M. Verheijen, Hans W. Nijman, Karen Duran, Ellen Stelloo, Christianne A.R. Lok, Petronella O. Witteveen, Christina Stangl, Joline F. Roze, Glen R. Monroe, Jurgen M.J. Piek, Ferdinando Sereno, Luc R.C.W. van Lonkhuijzen
Publikováno v:
Cancers, 13(3):368, 1-18. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 13(3):368, 1-18. MDPI AG
Cancers
Volume 13
Issue 3
Cancers, Vol 13, Iss 368, p 368 (2021)
Cancers, 13(3):368, 1-18. MDPI AG
Cancers
Volume 13
Issue 3
Cancers, Vol 13, Iss 368, p 368 (2021)
Adult granulosa cell tumors (AGCTs) arise from the estrogen-producing granulosa cells. Treatment of recurrence remains a clinical challenge, as systemic anti-hormonal treatment or chemotherapy is only effective in selected patients. We established a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c045c9140c78ebabd5b7e05778cde714
https://pure.amc.nl/en/publications/in-vitro-systematic-drug-testing-reveals-carboplatin-paclitaxel-and-alpelisib-as-a-potential-novel-combination-treatment-for-adult-granulosa-cell-tumors(a4eea90d-bfe4-4628-adf9-4696a43c9e61).html
https://pure.amc.nl/en/publications/in-vitro-systematic-drug-testing-reveals-carboplatin-paclitaxel-and-alpelisib-as-a-potential-novel-combination-treatment-for-adult-granulosa-cell-tumors(a4eea90d-bfe4-4628-adf9-4696a43c9e61).html