Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Glen R. Gale"'
Autor:
Mark A. Basinger, Mark M. Jones, Alayne B. Smith, Glen R. Gale, Wesley R. Harris, Pramod K. Singh
Publikováno v:
Chemical Research in Toxicology. 7:367-373
A novel method for the synthesis of monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) is presented which utilizes the reaction of the vicinal sulfhydryl-protected anhydride with the corresponding alcohol in the presence of a base. The product is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40944eb20a7bf7547d51af388f8961e5
https://doi.org/10.1021/tx00039a014
https://doi.org/10.1021/tx00039a014
Publikováno v:
Pharmacology & Toxicology. 74:76-83
Syntheses and relative cadmium mobilizing properties are described for three new monoaralkyl esters (HOOCCH(SH)CH(SH)COOR, where R = phenylethyl ((CH2)2C6H5), MPhEDMS; R = 3-phenylpropyl ((CH2)3C6H5), MPhPDMS; and R = 2-phenoxyethyl ((CH2)2OC6H5). MP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ea09ee08d8903b8e3ea70d52066782
https://doi.org/10.1111/j.1600-0773.1994.tb01079.x
https://doi.org/10.1111/j.1600-0773.1994.tb01079.x
Autor:
Angie Stone, Walker Em, Pramod K. Singh, Mark M. Jones, Mark A. Basinger, Glen R. Gale, Alayne B. Smith
Publikováno v:
Archives of Toxicology. 66:713-718
Administration of N-benzyl-N-lactyl dithiocarbamate (BLDTC) to mice after chronic cadmium (Cd) administration evoked a prompt, dose-dependent reduction of the whole body burden; 75% of the retained Cd was mobilized and excreted after 20 i.p. injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3263df0a3eef4c6e297b3d2700e770
https://doi.org/10.1007/bf01972622
https://doi.org/10.1007/bf01972622
Autor:
Loretta M. Atkins, Shirley G. Jones, Mark M. Jones, James A. Banton, Glen R. Gale, Pramod K. Singh, Chetan R. Mukundan, Alayne B. Smith
Publikováno v:
Chemical Research in Toxicology. 4:27-34
The effects of three major structural features on the intracellular cadmium mobilizing potency of dithiocarbamates have been examined. These features, the chirality of the groups, the total ionic charge of the chelating agent, and the extent of chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b851722a2834c2ade1b3d4aaedf1e748
https://doi.org/10.1021/tx00019a004
https://doi.org/10.1021/tx00019a004
Publikováno v:
Toxicology and Applied Pharmacology. 106:529-535
The cadmium mobilizing properties of two newly synthesized esters of meso-2,3-dimercaptosuccinic acid in mice have been examined. They are: di(2'-methoxyethyl) meso-2,3-dimercaptosuccinate ([-CH(SH)COOCH2CH2OR]2, R = CH3; MEDMS), and di(2'-ethoxyethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdf761b3e62e659f21c28d187fb46ac
https://doi.org/10.1016/0041-008x(90)90347-w
https://doi.org/10.1016/0041-008x(90)90347-w
Publikováno v:
Toxicology Letters. 50:85-96
A number of dosing regimens was assessed to determine the optimum schedule of administration of N -(4-methoxybenzyl)- N -dithiocarboxy- d -glucamine (MeOBDCG) in depleting whole-body, renal and hepatic levels of metallothionein-bound cadmium (Cd) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eb0fb00887428000ae459573c9b0d0
https://doi.org/10.1016/0378-4274(90)90255-k
https://doi.org/10.1016/0378-4274(90)90255-k
Autor:
Glen R. Gale, Mark M. Jones, Loretta M. Atkins, Alayne B. Smith, Mark A. Basinger, Angie Stone
Publikováno v:
Toxicology. 89(2)
The effects of chelating agent treatment with meso-2,3-dimercaptosuccinic acid (DMSA), Na2CaEDTA, Na2ZnEDTA, and Na3ZnDTPA on the organ lead levels of lead-loaded mice have been determined. At 1 mmol/kg/day i.p., all caused reductions in the lead lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dee272f384a79126a67dbb8d777b0ae
https://pubmed.ncbi.nlm.nih.gov/8197593
https://pubmed.ncbi.nlm.nih.gov/8197593
Autor:
Loretta M. Atkins, Alayne B. Smith, Mark M. Jones, Shirley G. Jones, Glen R. Gale, Pramod K. Singh
Publikováno v:
Chemical research in toxicology. 4(6)
The relationships between chemical structure and the relative ability to mobilize cadmium in vivo from its aged renal and hepatic deposits have been examined in a series of newly synthesized dithiocarbamates derived from lactose and maltotriose. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfa0dd8278317f7c9760f4f2751211c
https://pubmed.ncbi.nlm.nih.gov/1807453
https://pubmed.ncbi.nlm.nih.gov/1807453
Publikováno v:
Chemical research in toxicology. 4(4)
An examination of a group of dithiocarbamate chelating agents derived from various alkylamines and lactose reveals that the relative potencies in the mobilization of intracellular cadmium from renal and hepatic deposits in mice are highly dependent u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafdad89f88db956c16f51714f580c46
https://pubmed.ncbi.nlm.nih.gov/1912339
https://pubmed.ncbi.nlm.nih.gov/1912339
Autor:
Loretta M. Atkins, Shirley G. Jones, Pramod K. Singh, Alayne B. Smith, Glen R. Gale, Mark M. Jones
Publikováno v:
Chemico-biological interactions. 74(1-2)
The preparation and examination of three dithiocarbamates derived from N-substituted D-gluco-L-talooctamine reveals that the 4-methoxybenzyl derivative (MeOBGD) is superior to any previously prepared dithiocarbamates as an agent for the mobilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06303262282f24645b7deef7cdaea9d
https://pubmed.ncbi.nlm.nih.gov/2182202
https://pubmed.ncbi.nlm.nih.gov/2182202