Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Glen Munson"'
Autor:
Gavin R. Schnitzler, Helen Kang, Vivian S. Lee-Kim, X. Rosa Ma, Tony Zeng, Ramcharan S. Angom, Shi Fang, Shamsudheen Karuthedath Vellarikkal, Ronghao Zhou, Katherine Guo, Oscar Sias-Garcia, Alex Bloemendal, Glen Munson, Philine Guckelberger, Tung H. Nguyen, Drew T. Bergman, Nathan Cheng, Brian Cleary, Krishna Aragam, Debabrata Mukhopadhyay, Eric S. Lander, Hilary K. Finucane, Rajat M. Gupta, Jesse M. Engreitz
Genome-wide association studies (GWAS) have discovered thousands of risk loci for common, complex diseases, each of which could point to genes and gene programs that influence disease. For some diseases, it has been observed that GWAS signals converg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68bba175f1157fd63e5f5dccdcf1c6d9
https://doi.org/10.1101/2022.11.01.514606
https://doi.org/10.1101/2022.11.01.514606
Autor:
Jorge D. Martin-Rufino, Nicole Castano, Michael Pang, Emanuelle I. Grody, Samantha Joubran, Alexis Caulier, Lara Wahlster, Tongqing Li, Xiaojie Qiu, Anna Maria Riera-Escandell, Gregory A. Newby, Aziz Al’Khafaji, Santosh Chaudhary, Susan Black, Chen Weng, Glen Munson, David R. Liu, Marcin W. Wlodarski, Kacie Sims, Jamie H. Oakley, Ross M. Fasano, Ramnik J. Xavier, Eric S. Lander, Daryl E. Klein, Vijay G. Sankaran
Publikováno v:
Cell. 186:2456-2474.e24
Autor:
Arnav Mehta, Lynn Bi, Aziz Al'Khafaji, Martin Jankowiak, Milan Parikh, Mehrtash Babadi, Alex Bloemendal, Marc Schwartz, Glen Munson, Joeseph Chan, Cassandra Burdziak, Elisa Donnard, Ryan Park, Chen Lu, Philippe Rigollet, Andrew Aguirre, Vidya Subramanian, Ray Jones, Eric S. Lander, David T. Ting, Dana Pe'er, Nir Hacohen
Publikováno v:
Cancer Research. 82:B016-B016
Pancreatic cancer is a lethal disease in part because tumor cells exist in distinct transcriptional phenotypes (e.g. basal and classical states), each with a selective ability to evade current chemotherapy regimens. Two major mechanisms have been sug
Autor:
Tejal A. Patwardhan, Fritz Lekschas, Jesse M. Engreitz, Alkes L. Price, Hanspeter Pfister, Mark J. Daly, Glen Munson, Michael Kane, Jacob C. Ulirsch, Helen Y. Kang, Nir Hacohen, Ramnik J. Xavier, Anshul Kundaje, Heini M. Natri, Elle M. Weeks, Tung T. Nguyen, Drew T. Bergman, Benjamin R. Doughty, Thouis R. Jones, Eric S. Lander, Joseph Nasser, Kristy Mualim, Thomas Eisenhaure, Ryan L. Collins, Philine Guckelberger, Kushal K. Dey, John P. Ray, Ang Cui, Hilary K. Finucane, Charles P. Fulco, Hailiang Huang, Charles B. Epstein
Publikováno v:
Nature
Genome-wide association studies (GWAS) have identified thousands of noncoding loci that are associated with human diseases and complex traits, each of which could reveal insights into the mechanisms of disease1. Many of the underlying causal variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d0ccb04cb7636886b8aa9ef621df7d
https://europepmc.org/articles/PMC9153265/
https://europepmc.org/articles/PMC9153265/
Autor:
Tejal A. Patwardhan, Tom M. Eisenhaure, Benjamin R. Doughty, Jacob C. Ulirsch, Thouis R. Jones, Tung T. Nguyen, Michael Kane, Kushal K. Dey, Helen Y. Kang, Philine Guckelberger, Mark J. Daly, Elle M. Weeks, Joseph Nasser, Drew T. Bergman, Anshul Kundaje, Jesse M. Engreitz, Ang Cui, Hilary K. Finucane, Alkes L. Price, Glen Munson, John P. Ray, Nir Hacohen, Kristy Mualim, Eric S. Lander, Heini M. Natri, Charles B. Epstein, Ramnik J. Xavier, Charles P. Fulco, Hailiang Huang, Ryan L. Collins
Genome-wide association studies have now identified tens of thousands of noncoding loci associated with human diseases and complex traits, each of which could reveal insights into biological mechanisms of disease. Many of the underlying causal varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af602c085e001e44d42cac6b461e53ec
https://doi.org/10.1101/2020.09.01.278093
https://doi.org/10.1101/2020.09.01.278093
Autor:
Sharon R. Grossman, Glen Munson, Joseph Nasser, Drew T. Bergman, Elizabeth M. Perez, Michael Kane, Elena K. Stamenova, Benjamin R. Doughty, Thouis R. Jones, Charles P. Fulco, Rockwell Anyoha, Eric S. Lander, Neva C. Durand, Tung T. Nguyen, Tejal A. Patwardhan, Vidya Subramanian, Jesse M. Engreitz, Erez Lieberman Aiden
Mammalian genomes harbor millions of noncoding elements called enhancers that quantitatively regulate gene expression, but it remains unclear which enhancers regulate which genes. Here we describe an experimental approach, based on CRISPR interferenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a9c53caf034ef390045c07f233f26d
https://doi.org/10.1101/529990
https://doi.org/10.1101/529990
Autor:
Sharon R. Grossman, Glen Munson, Charles P. Fulco, Thouis R. Jones, Tejal A. Patwardhan, Caleb A. Lareau, Drew T. Bergman, Jesse M. Engreitz, Vidya Subramanian, Elena K. Stamenova, Rockwell Anyoha, Benjamin R. Doughty, Elizabeth M. Perez, Erez Lieberman Aiden, Michael Kane, Eric S. Lander, Joseph Nasser, Tung T. Nguyen, Neva C. Durand
Publikováno v:
Nature genetics
Enhancer elements in the human genome control how genes are expressed in specific cell types and harbor thousands of genetic variants that influence risk for common diseases1-4. Yet, we still do not know how enhancers regulate specific genes, and we
Autor:
Jenny Chen, Glen Munson, Mitchell Guttman, Jesse M. Engreitz, Michael Kane, Jenna E. Haines, Elizabeth M. Perez, Eric S. Lander, Patrick McDonel
Mammalian genomes are pervasively transcribed(1,2) to produce thousands of long noncoding RNAs (lncRNAs)(3,4). A few of these lncRNAs have been shown to recruit regulatory complexes through RNA-protein interactions to influence the expression of near
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8ac3e13f60d3f4210bf503e3ff86f2
https://resolver.caltech.edu/CaltechAUTHORS:20161012-162725499
https://resolver.caltech.edu/CaltechAUTHORS:20161012-162725499
Autor:
Michael Kane, Jesse M. Engreitz, Rockwell Anyoha, Elizabeth M. Perez, Glen Munson, Sharon R. Grossman, Charles P. Fulco, Mathias Munschauer, Eric S. Lander, Brian Cleary
CRISPR screens illuminate enhancer function The noncoding regions around a gene that control the transcription of the protein-coding region are difficult to identify. Leveraging a CRISPR interference system (CRISPRi), Fulco et al. identified enhancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1152aafeda69288bc03fdf2ea20c7f
https://europepmc.org/articles/PMC5438575/
https://europepmc.org/articles/PMC5438575/
Autor:
Jesse M. Engreitz, Michael Kane, Elizabeth M. Perez, Jenna E. Haines, Mitchell Guttman, Eric S. Lander, Glen Munson, Patrick McDonel, Jenny Chen
Mammalian genomes are pervasively transcribed to produce thousands of spliced long noncoding RNAs (lncRNAs), whose functions remain poorly understood. Because recent evidence has implicated several specific lncRNA loci in the local regulation of gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bc04d4d33025417ec2b6afe224ffd9