Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Glen M, Chew"'
Autor:
Juan A. Perez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, Daniel Lord, B. Joy Quejarro, Jade Sales-Lee, Meet Shah, Brian J. Silva, Jason Skowronski, Yuri G. Strukov, Joshua Thomas, Michael Veraz, Twaritha Vijay, Kirby A. Wallace, Yue Yuan, Jane L. Grogan, Beeke Wienert, Premanjali Lahiri, Sebastian Treusch, Daniel P. Dever, Vanessa B. Soros, James R. Partridge, Kristen L. Seim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Jo
Externí odkaz:
https://doaj.org/article/620ea33bf16f4f77a76fcba73efa8992
Autor:
Xiao L. Chang, Gabriela M. Webb, Helen L. Wu, Justin M. Greene, Shaheed Abdulhaqq, Katherine B. Bateman, Jason S. Reed, Cleiton Pessoa, Whitney C. Weber, Nicholas Maier, Glen M. Chew, Roxanne M. Gilbride, Lina Gao, Rebecca Agnor, Travis Giobbi, Jeffrey Torgerson, Don Siess, Nicole Burnett, Miranda Fischer, Oriene Shiel, Cassandra Moats, Bruce Patterson, Kush Dhody, Scott Kelly, Nader Pourhassan, Diogo M. Magnani, Jeremy Smedley, Benjamin N. Bimber, Nancy L. Haigwood, Scott G. Hansen, Timothy R. Brown, Lishomwa C. Ndhlovu, Jonah B. Sacha
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
CCR5 is a co-receptor for many transmitted HIV strains. Here, the authors show that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges of a CCR5-tropic SHIV
Externí odkaz:
https://doaj.org/article/e057d02dc1bf44278b9075dfe29c62e7
Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells
Autor:
Opeyemi S. Adeniji, Leticia Kuri-Cervantes, Chenfei Yu, Ziyang Xu, Michelle Ho, Glen M. Chew, Cecilia Shikuma, Costin Tomescu, Ashley F. George, Nadia R. Roan, Lishomwa C. Ndhlovu, Qin Liu, Kar Muthumani, David B. Weiner, Michael R. Betts, Han Xiao, Mohamed Abdel-Mohsen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK) cells. Siglec-9 restrains NK cytotoxicity by binding to sialoglycans (sialic acid-containing glycans) on target cells. Despite the importance of Siglec-9
Externí odkaz:
https://doaj.org/article/db11dfbb65534cb3924abe59420fa723
Autor:
Danielle M. Clements, Brenndan Crumley, Glen M. Chew, Elijah Davis, Roberta Bruhn, Edward L. Murphy, Lishomwa C. Ndhlovu, Pooja Jain
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) develops in 1–5% of HTLV-1-infected individuals. Previous studies by us and others have shown that the expression of negative immune checkp
Externí odkaz:
https://doaj.org/article/fc7b85aac1ec4ddcac0656dff6dac38c
Autor:
Robert H. Paul, Cecilia M. Shikuma, Nguyen Van Vinh Chau, Lishomwa C. Ndhlovu, Nguyen Tat Thanh, Andrew C. Belden, Dominic C. Chow, Glen M. Chew, Thomas A. Premeaux, Vo Trieu Ly, Joseph A. D. McBride, Jacob D. Bolzenius, Thuy Le
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Long-term neurocognitive outcomes following first-line suppressive anti-retroviral therapy (ART) remain uncertain for individuals with HIV and hepatitis C (HCV) co-infection. The study examined neurocognitive performance before and after
Externí odkaz:
https://doaj.org/article/72b63a1d77724ca5a274f4c58fddb45b
Autor:
Louie Mar A Gangcuangco, Brooks I Mitchell, Chathura Siriwardhana, Lindsay B Kohorn, Glen M Chew, Scott Bowler, Kalpana J Kallianpur, Dominic C Chow, Lishomwa C Ndhlovu, Mariana Gerschenson, Cecilia M Shikuma
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249428 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0231761.].
Externí odkaz:
https://doaj.org/article/5ec772fbe0d14d2e89f3ff06188cd265
Autor:
Louie Mar A Gangcuangco, Brooks I Mitchell, Chathura Siriwardhana, Lindsay B Kohorn, Glen M Chew, Scott Bowler, Kalpana J Kallianpur, Dominic C Chow, Lishomwa C Ndhlovu, Mariana Gerschenson, Cecilia M Shikuma
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231761 (2020)
BackgroundCellular immunometabolism among people living with HIV (PLWH) on antiretroviral therapy (ART) remains under investigated. We assessed the relationships between mitochondrial oxidative phosphorylation (OXPHOS) in peripheral blood mononuclear
Externí odkaz:
https://doaj.org/article/def23153c77242029126fa8dfafcfe7a
Autor:
Peter R. Hoffmann, Fukun W. Hoffmann, Thomas A. Premeaux, Tsuyoshi Fujita, Elisa Soprana, Maddalena Panigada, Glen M. Chew, Guilhem Richard, Pooja Hindocha, Mark Menor, Vedbar S. Khadka, Youping Deng, Lenny Moise, Lishomwa C. Ndhlovu, Antonio Siccardi, Andrew D. Weinberg, Anne S. De Groot, Pietro Bertino
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Malignant Mesothelioma (MM) is a rare and highly aggressive cancer that develops from mesothelial cells lining the pleura and other internal cavities, and is often associated with asbestos exposure. To date, no effective treatments have been made ava
Externí odkaz:
https://doaj.org/article/0f603f7d2a08458883df761ca242f4fe
Autor:
Hayk Ghukasyan, Thuy Le, Cecilia M. Shikuma, Nath Limpruttdham, Trieu Ly Vo, Lishomwa C. Ndhlovu, Louie Mar A Gangcuangco, Glen M. Chew, Thomas A. Premeaux, Robert H. Paul, Thao Vu Phuong, Dominic C. Chow, Van Vinh Chau Nguyen, Chathura Siriwardhana
Publikováno v:
AIDS Res Hum Retroviruses
The impact of HIV antiretroviral therapy (ART) on immune dysregulation associated with hepatitis C virus (HCV)/HIV coinfection is incompletely understood. We serially assessed monocyte activation (neopterin, sCD14, and sCD163) and T cell activation (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bf34bf5b3379b6b74698f0f7763375
https://doi.org/10.1089/aid.2021.0076
https://doi.org/10.1089/aid.2021.0076
Autor:
Bruce K. Patterson, Whitney C. Weber, Gabriela M. Webb, Katherine B. Bateman, Cleiton Pessoa, Shaheed A. Abdulhaqq, Lina Gao, Benjamin N. Bimber, Jonah B. Sacha, Scott G. Hansen, Xiao L. Chang, Justin M. Greene, Kush Dhody, Scott Kelly, Nancy L. Haigwood, Rebecca Agnor, Cassandra Moats, Glen M. Chew, Roxanne M. Gilbride, Jeremy Smedley, Nicole D Burnett, Oriene Shiel, Nicholas Maier, Don Siess, Lishomwa C. Ndhlovu, Miranda Fischer, Timothy R. Brown, Diogo M. Magnani, Jason S. Reed, Travis Giobbi, Jeffrey Torgerson, Helen L. Wu, Nader Pourhassan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
In the absence of a prophylactic vaccine, the use of antiretroviral therapy (ART) as pre-exposure prophylaxis (PrEP) to prevent HIV acquisition by uninfected individuals is a promising approach to slowing the epidemic, but its efficacy is hampered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e606e6b89376a17f5abd25dc4b8683a
https://doaj.org/article/e057d02dc1bf44278b9075dfe29c62e7
https://doaj.org/article/e057d02dc1bf44278b9075dfe29c62e7