Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Glen K. Andrews"'
Mammalian metallothionein (MT) genes are transcriptionally activated by the essential metal zinc as well as by environmental stresses, including toxic metal overload and redox fluctuations. In addition to playing a key role in zinc homeostasis, MT pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dea88a427bdf3010423cbdae83602e
https://doi.org/10.1158/1541-7786.c.6541456.v1
https://doi.org/10.1158/1541-7786.c.6541456.v1
Autor:
Wolfgang Maret, Julia Margaret Wendy Gee, Olivia Ogle, Silvia Ziliotto, Kathryn Mary Taylor, Christer Hogstrand, Glen K. Andrews, Anna L. Burt, Peter Kille, Thirayost Nimmanon
Publikováno v:
Cellular and Molecular Life Sciences
Zinc has been known to be essential for cell division for over 40 years but the molecular pathways involved remain elusive. Cellular zinc import across biological membranes necessitates the help of zinc transporters such as the SLC39A family of ZIP t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f757a4c8d0a33bcaaae69195a943a4c4
https://doi.org/10.1007/s00018-020-03616-6
https://doi.org/10.1007/s00018-020-03616-6
Autor:
Alexandre B Hardy, Kacey J Prentice, Sean Froese, Ying Liu, Glen K Andrews, Michael B Wheeler
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119136 (2015)
Zinc has an important role in normal pancreatic beta cell physiology as it regulates gene transcription, insulin crystallization and secretion, and cell survival. Nevertheless, little is known about how zinc is transported through the plasma membrane
Externí odkaz:
https://doaj.org/article/9f21483cbac74609b65bae78c74b071e
Autor:
Johannes Engelken, Elena Carnero-Montoro, Marc Pybus, Glen K Andrews, Carles Lalueza-Fox, David Comas, Israel Sekler, Marco de la Rasilla, Antonio Rosas, Mark Stoneking, Miguel A Valverde, Rubén Vicente, Elena Bosch
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004128 (2014)
Extreme differences in allele frequency between West Africans and Eurasians were observed for a leucine-to-valine substitution (Leu372Val) in the human intestinal zinc uptake transporter, ZIP4, yet no further evidence was found for a selective sweep
Externí odkaz:
https://doaj.org/article/0668f809dc2e42c7bd051513697e99b0
Autor:
Jim Geiser, Robert C De Lisle, David Finkelstein, Paul A Adlard, Ashley I Bush, Glen K Andrews
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72543 (2013)
BackgroundZinc deficiency due to poor nutrition or genetic mutations in zinc transporters is a global health problem and approaches to providing effective dietary zinc supplementation while avoiding potential toxic side effects are needed.Methods/pri
Externí odkaz:
https://doaj.org/article/83a06b4ef9494a5aab94221ac8aff609
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e82149 (2013)
ZIP5 localizes to the baso-lateral membranes of intestinal enterocytes and pancreatic acinar cells and is internalized and degraded coordinately in these cell-types during periods of dietary zinc deficiency. These cell-types are thought to control zi
Externí odkaz:
https://doaj.org/article/7c89b091af7d4f3e934652a5bc218e4b
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002766 (2012)
Mutations in the human Zip4 gene cause acrodermatitis enteropathica, a rare, pseudo-dominant, lethal genetic disorder. We created a tamoxifen-inducible, enterocyte-specific knockout of this gene in mice which mimics this human disorder. We found that
Externí odkaz:
https://doaj.org/article/6114b6f5a14b40c5a81eabaeb4b40098
Transgenic expression of human LAMA5 suppresses murine Lama5 mRNA and laminin α5 protein deposition.
Autor:
Brooke M Steenhard, Adrian Zelenchuk, Larysa Stroganova, Kathryn Isom, Patricia L St John, Glen K Andrews, Kenneth R Peterson, Dale R Abrahamson
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23926 (2011)
Laminin α5 is required for kidney glomerular basement membrane (GBM) assembly, and mice with targeted deletions of the Lama5 gene fail to form glomeruli. As a tool to begin to understand factors regulating the expression of the LAMA5 gene, we genera
Externí odkaz:
https://doaj.org/article/ce36c9499a88422188821db72e303a18
Autor:
Benjamin P Weaver, Yuxia Zhang, Stephen Hiscox, Grace L Guo, Udayan Apte, Kathryn M Taylor, Christian T Sheline, Li Wang, Glen K Andrews
Publikováno v:
PLoS ONE, Vol 5, Iss 10 (2010)
The zinc transporter ZIP4 (Slc39a4) is important for proper mammalian development and is an essential gene in mice. Recent studies suggest that this gene may also play a role in pancreatic cancer.Herein, we present evidence that this essential zinc t
Externí odkaz:
https://doaj.org/article/b4f5ef4e4b0a469f809acaaa23f9acaf
Autor:
Silvia Ziliotto, Christer Hogstrand, Thirayost Nimmanon, Peter Kille, Olivia Ogle, Kathryn Mary Taylor, Wolfgang Maret, Glen K. Andrews, Julia Mw Gee, Anna L. Burt
Publikováno v:
SSRN Electronic Journal.
Zinc has been known to be essential for cell division for over 40 years, but the exact mechanism remains elusive. Cellular zinc import necessitates the help of the SLC39A family of ZIP transporters, two of which are known to be essential for gastrula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51585bf8c91718b9dd209a915ed20750
https://doi.org/10.2139/ssrn.3444945
https://doi.org/10.2139/ssrn.3444945