Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Glen Hawthorne"'
Autor:
Elisabetta Leo, Sabina Cosulich, James Yates, Joanne Wilson, Harriet Southgate, Aaron Smith, Mark J. O'Connor, Jenni Nikkilä, Gareth Maglennon, Ruth Macdonald, Emilyanne Leonard, Jeffrey Johannes, Kunzah Jamal, Glen Hawthorne, Stephen Fawell, Anna Cronin, Susan E. Critchlow, Lisa McWilliams, Andy Pike, Sonja J. Gill, Anna D. Staniszewska, Giuditta Illuzzi
Supplementary Data from Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b51a5c301c6edc9e5d86cdcc1239b13
https://doi.org/10.1158/1078-0432.22488935.v1
https://doi.org/10.1158/1078-0432.22488935.v1
Autor:
Elisabetta Leo, Sabina Cosulich, James Yates, Joanne Wilson, Harriet Southgate, Aaron Smith, Mark J. O'Connor, Jenni Nikkilä, Gareth Maglennon, Ruth Macdonald, Emilyanne Leonard, Jeffrey Johannes, Kunzah Jamal, Glen Hawthorne, Stephen Fawell, Anna Cronin, Susan E. Critchlow, Lisa McWilliams, Andy Pike, Sonja J. Gill, Anna D. Staniszewska, Giuditta Illuzzi
Purpose:We hypothesized that inhibition and trapping of PARP1 alone would be sufficient to achieve antitumor activity. In particular, we aimed to achieve selectivity over PARP2, which has been shown to play a role in the survival of hematopoietic/ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d708dc305d7cfaab263c167f3caeef
https://doi.org/10.1158/1078-0432.c.6532832.v1
https://doi.org/10.1158/1078-0432.c.6532832.v1
Autor:
Elisabetta Leo, Sabina Cosulich, James Yates, Joanne Wilson, Harriet Southgate, Aaron Smith, Mark J. O'Connor, Jenni Nikkilä, Gareth Maglennon, Ruth Macdonald, Emilyanne Leonard, Jeffrey Johannes, Kunzah Jamal, Glen Hawthorne, Stephen Fawell, Anna Cronin, Susan E. Critchlow, Lisa McWilliams, Andy Pike, Sonja J. Gill, Anna D. Staniszewska, Giuditta Illuzzi
Supplementary Figure from Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077a5ba1a2d0e13db736793ffd438973
https://doi.org/10.1158/1078-0432.22488920.v1
https://doi.org/10.1158/1078-0432.22488920.v1
Autor:
Giuditta Illuzzi, Anna D. Staniszewska, Sonja J. Gill, Andy Pike, Lisa McWilliams, Susan E. Critchlow, Anna Cronin, Stephen Fawell, Glen Hawthorne, Kunzah Jamal, Jeffrey Johannes, Emilyanne Leonard, Ruth Macdonald, Gareth Maglennon, Jenni Nikkilä, Mark J. O'Connor, Aaron Smith, Harriet Southgate, Joanne Wilson, James Yates, Sabina Cosulich, Elisabetta Leo
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(21)
Purpose: We hypothesized that inhibition and trapping of PARP1 alone would be sufficient to achieve antitumor activity. In particular, we aimed to achieve selectivity over PARP2, which has been shown to play a role in the survival of hematopoietic/st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37f1456d11cb64b84480a9b2fa64b57
https://pubmed.ncbi.nlm.nih.gov/35929986
https://pubmed.ncbi.nlm.nih.gov/35929986
Publikováno v:
Bioanalysis. 11:1993-2001
Aim: Chemically modified mRNA offers a novel approach to treat disease. Due to susceptibility to extracellular nucleases in vivo, dosed modified mRNA therapeutics can benefit from encapsulation within novel delivery systems, such as lipid nanoparticl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cab60752e1f731bb25c6bdccab01bb
https://doi.org/10.4155/bio-2019-0138
https://doi.org/10.4155/bio-2019-0138
Publikováno v:
Bioanalysis. 11:595-599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8f3ab629d2a8a409c8625a43c7b864
https://doi.org/10.4155/bio-2019-0037
https://doi.org/10.4155/bio-2019-0037
Autor:
Yongjun Xue, Glen Hawthorne, Wanping Geng, James Vergis, Andrew P Mayer, Jonathan Wang, Christopher A. James, Lucas Westcott-Baker, Yvonne Katterle, Martin Paton, Jorge Quiroz, Julian Potter, Stephen Keller, Wenkui Li, Dave Christopher, Enaksha R Wickremsinhe, Eric Woolf, Guowen Liu, Joseph Pav
Publikováno v:
Bioanalysis. 13(3)
The use of quality control (QC) samples in bioanalysis is well established and consistent with regulatory guidance. However, a systematic evaluation of whether QC samples serve the intended purpose of improving data quality has not been undertaken. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e33250ce5da0134956c79ddf1a7c3a
https://pubmed.ncbi.nlm.nih.gov/33538614
https://pubmed.ncbi.nlm.nih.gov/33538614
Autor:
Hans M.G. Princen, Linnéa Bergenholm, Jonathan Bright, Maria Hammarberg, Eva Lundborg, Elsbet J. Pieterman, Rahul Agrawal, Glen Hawthorne, Annica Jarke, Anders Cavallin, Eva Hurt-Camejo, Bertil Abrahamsson, Rasmus Jansson-Löfmark, V. Sashi Gopaul, Magnus Johansson, Anders Björkbom, Lena Svensson, Xue-Qing Li
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 161
We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a lipop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f737b1c0be3d6cf693275c5ad53007e
https://pubmed.ncbi.nlm.nih.gov/33667667
https://pubmed.ncbi.nlm.nih.gov/33667667
Autor:
Rebecca Sargeant, Ruth Macdonald, Jordan Pugh, Stewart Jones, Daniel Sutton, Emilyanne Leonard, Mark J. Anderton, Carmen Pin, James Atkinson, Rob Collins, Glen Hawthorne, Sarah Chinery, Sonja J. Gill, Andrew Pike, Peter Cotton, Gareth Maglennon
Publikováno v:
Cancer Research. 81:1374-1374
Current clinical poly (ADP-ribose) polymerase (PARP) inhibitors target both PARP1 and PARP2 and they all cause clinical cytopenias with varying severity. Understanding the mechanism underlying the hematological toxicity of these agents is key for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::623cbc36a0e0ecbd263b2129c95b6964
https://doi.org/10.1158/1538-7445.am2021-1374
https://doi.org/10.1158/1538-7445.am2021-1374
Publikováno v:
Bioanalysis. 10:275-277
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842829162b6a84a78b3e6147ea661bb6
https://doi.org/10.4155/bio-2017-0279
https://doi.org/10.4155/bio-2017-0279