Conference report on contractures in musculoskeletal and neurological conditions

Autor: Sabrina S.M. Lee, Yetrib Hathout, Elizabeth M. McNally, Craig M. McDonald, Seward B. Rutkove, Leslie F. Vogel, Sudarshan Dayanidhi, Andrea A. Domenighetti, Glen H. Nuckolls, William Z. Rymer, Rebecca J. Willcocks, Preeti Raghavan, S. Peter Magnusson, Richard L. Lieber, Glenn A. Walter, Michael W. Lawlor, Kathi Kinnett, John F. Sarwark, Bradley B. Olwin, N. Miller, Thomas J. Roberts, Claudia R. Senesac, Tina Duong

Publikováno v: Muscle Nerve

Limb contractures are debilitating complications associated with various muscle and nervous system disorders. This report summarizes presentations at a conference at the Shirley Ryan AbilityLab in Chicago, Illinois, on April 19-20, 2018, involving re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36eaa8a81013fb52692416a6dac6e1d
https://pubmed.ncbi.nlm.nih.gov/32108365

Perspectives on best practices for gene therapy programs

Autor: Katherine A. High, John M. Lincecum, Brian K. Kaspar, Glen H. Nuckolls, Danilo A. Tagle, Dale Berkley, Luk H. Vandenberghe, Fulvio Mavilio, James M. Wilson, Serge Braun, Pamela J. Wernett, Cheryl L. McDonald, James McLaughlin, Jane Larkindale, Valerie Cwik, Thomas R. Cheever, Dongsheng Duan, Barry J. Byrne, Hansell H. Stedman, Katherine W. Klinger, John D. Porter, Robert H. Brown, Jeffrey S. Chamberlain, Hao Wang, Bonnie Weiss McLeod, Amelie K. Gubitz, Jerry R. Mendell, Howard J. Federoff

Publikováno v: Human Gene Therapy
Human Gene Therapy, 2015, 26 (3), pp.127-33. ⟨10.1089/hum.2014.147⟩
Human Gene Therapy, Mary Ann Liebert, 2015, 26 (3), pp.127-33. ⟨10.1089/hum.2014.147⟩
Human gene therapy, vol 26, iss 3

International audience; With recent successes in gene therapy trials for hemophilia and retinal diseases, the promise and prospects for gene therapy are once again garnering significant attention. To build on this momentum, the National Institute of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f962fe8f427bb91371406b89c94a3fc3
https://hal.science/hal-02880972

Cbfβ interacts with Runx2 and has a critical role in bone development

Autor: Yingzi Yang, Gary S. Stein, Alan Horner, Glen H. Nuckolls, Michael Eckhaus, Jane B. Lian, Mondira Kundu, Pengfei Liu, Amjad Javed, Lillian Shum, Jae-Pil Jeon, Maximilian Muenke

Publikováno v: Nature Genetics. 32:639-644

Runx2 (runt-related transcription factor 2, also known as Cbfa1, Osf2 and AML3) is essential for bone development in mice, and mutations in RUNX2 are found in 65-80% of individuals with cleidocranial dysplasia. Although all Runx family members can in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f666109b8345ce480bf45b081eae00
https://doi.org/10.1038/ng1050

YY1 activates Msx2 gene independent of bone morphogenetic protein signaling

Autor: Harold C. Slavkin, Robert E. Maxson, D. P. Tan, Yufeng Liu, Lillian Shum, Glen H. Nuckolls, Kazuaki Nonaka

Publikováno v: Nucleic Acids Research. 30:1213-1223

Msx2 is a homeobox gene expressed in multiple embryonic tissues which functions as a key mediator of numerous developmental processes. YY1 is a bi-functional zinc finger protein that serves as a repressor or activator to a variety of promoters. The r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647b702d5f9c5b1b87626ae4c580ecb5
https://doi.org/10.1093/nar/30.5.1213

Msx2 is a repressor of chondrogenic differentiation in migratory cranial neural crest cells

Autor: Masaki Nagata, Glen H. Nuckolls, Kazuaki Nonaka, Ichiro Takahashi, Lillian Shum, Katsu Takahashi, Harold C. Slavkin, Tsuyoshi Ikura

Publikováno v: Developmental Dynamics. 222:252-262

During early mouse embryogenesis, cranial neural crest cells (CNCC) emigrate from the posterior midbrain and rhombomeres 1 and 2 of the anterior hindbrain into the first branchial arch-derived maxillary and mandibular processes and there provide cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05dfca5c95f5cd2c6911a76c40f2799
https://doi.org/10.1002/dvdy.1185