Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Glen F. Tibbits"'
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/9583eeb68b05410e81fa03ac8d87ad6c
Autor:
Hosna Babini, Verónica Jiménez-Sábado, Ekaterina Stogova, Alia Arslanova, Mariam Butt, Saif Dababneh, Parisa Asghari, Edwin D. W. Moore, Thomas W. Claydon, Nipavan Chiamvimonvat, Leif Hove-Madsen, Glen F. Tibbits
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Atrial fibrillation (AF), the most common arrhythmia, has been associated with different electrophysiological, molecular, and structural alterations in atrial cardiomyocytes. Therefore, more studies are required to elucidate the genetic and molecular
Externí odkaz:
https://doaj.org/article/9fb5fce9358747888e15f06698dd86da
Autor:
Homa Hamledari, Parisa Asghari, Farah Jayousi, Alejandro Aguirre, Yasaman Maaref, Tiffany Barszczewski, Terri Ser, Edwin Moore, Wyeth Wasserman, Ramon Klein Geltink, Sheila Teves, Glen F. Tibbits
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Cardiovascular diseases are the leading cause of mortality and reduced quality of life globally. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a personalized platform to study inherited heart diseases, drug-induced ca
Externí odkaz:
https://doaj.org/article/a3932d3cfb82427bb05050a26ea9dd73
Autor:
Sanam Shafaattalab, Eric Lin, Effimia Christidi, Haojun Huang, Yulia Nartiss, Analucia Garcia, Jeehon Lee, Stephanie Protze, Gordon Keller, Liam Brunham, Glen F. Tibbits, Zachary Laksman
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 996-1006 (2019)
Summary: Ibrutinib (IB) is an oral Bruton's tyrosine kinase (BTK) inhibitor that has demonstrated benefit in B cell cancers, but is associated with a dramatic increase in atrial fibrillation (AF). We employed cell-specific differentiation protocols a
Externí odkaz:
https://doaj.org/article/b3c9cfe24c6e4d08bfc7e821d9e4dae7
Autor:
Kyle E. Simpson, Ravichandra Venkateshappa, Zhao Kai Pang, Shoaib Faizi, Glen F. Tibbits, Tom W. Claydon
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Long-QT Syndrome (LQTS) is a cardiac electrical disorder, distinguished by irregular heart rates and sudden death. Accounting for ∼40% of cases, LQTS Type 2 (LQTS2), is caused by defects in the Kv11.1 (hERG) potassium channel that is critical for c
Externí odkaz:
https://doaj.org/article/b450a30b75aa4511bf75650755a958cf
Autor:
Dania Kallas, Avani Lamba, Thomas M. Roston, Alia Arslanova, Sonia Franciosi, Glen F. Tibbits, Shubhayan Sanatani
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9293 (2021)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare and potentially lethal inherited arrhythmia disease characterized by exercise or emotion-induced bidirectional or polymorphic ventricular tachyarrhythmias. The median age of disea
Externí odkaz:
https://doaj.org/article/6b4d706bdf844aaab93f67c1c6a317f3
Autor:
Zachary Laksman, Marianne Wauchop, Eric Lin, Stephanie Protze, Jeehoon Lee, Wallace Yang, Farzad Izaddoustdar, Sanam Shafaattalab, Lior Gepstein, Glen F. Tibbits, Gordon Keller, Peter H. Backx
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF for pharmacologic testing. We generated atrial-like card
Externí odkaz:
https://doaj.org/article/de4c7f423d3d4347aaa96056d0036cc4
Autor:
Kaveh Rayani, Eric R. Hantz, Omid Haji‐Ghassemi, Alison Y. Li, Anne M. Spuches, Filip Van Petegem, R. John Solaro, Steffen Lindert, Glen F. Tibbits
Publikováno v:
The FEBS Journal. 289:7446-7465
Autor:
Paulina Langa, Sanam Shafaattalab, Paul H. Goldspink, Beata M. Wolska, Aurelia A. Fernandes, Glen F. Tibbits, R. John Solaro
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
In this perspective, we discussed emerging data indicating a role for Notch signalling in inherited disorders of the heart failure with focus on hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) linked to variants of genes encoding m
Autor:
Kate Huang, Mishal Ashraf, Leili Rohani, Yinhan Luo, Ardin Sacayanan, Haojun Huang, Anne Haegert, Stanislav Volik, Funda Sar, Stéphane LeBihan, Janet Liew, Jason D. Roberts, Glen F. Tibbits, Jared M. Churko, Shubhayan Sanatani, Colin Collins, Liam R. Brunham, Zachary W. Laksman
BackgroundProtein truncating mutations in the titin gene are associated with increased risk of atrial fibrillation (AF). However, little is known regarding the underlying pathophysiology.MethodsWe identified a heterozygous titin truncating variant in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e683910296e17cbec11da9f3984e918c
https://doi.org/10.1101/2023.03.02.530843
https://doi.org/10.1101/2023.03.02.530843