Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Glen E. Palmer"'
Autor:
Jian Miao, Jessica Regan, Chun Cai, Glen E. Palmer, David L. Williams, Michael D. Kruppa, Brian M. Peters
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT The polymorphic fungus Candida albicans remains a leading cause of both invasive and superficial mycoses, including vulvovaginal candidiasis (VVC). Metabolic plasticity, including carbohydrate catabolism, confers fitness advantages at anatom
Externí odkaz:
https://doaj.org/article/1de41200d62b4cc183dadf2e409c26eb
Autor:
Jessica Regan, Christian DeJarnette, Arturo Luna-Tapia, Josie E. Parker, Parker Reitler, Stacey Barnett, Katie M. Tucker, Steven L. Kelly, Glen E. Palmer
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The azole antifungals inhibit sterol 14α-demethylase (S14DM), which depletes cellular ergosterol and promotes synthesis of the dysfunctional lipid 14α-methylergosta-8,24(28)-dien-3β,6α-diol, ultimately arresting growth. Mutations that in
Externí odkaz:
https://doaj.org/article/ef3d15f8a1ad4a89b45ba215dd9b1f99
Autor:
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris
Externí odkaz:
https://doaj.org/article/11fc8a65bf524a0eb9afa9a462436f19
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Autor:
Ana Camila Oliveira Souza, Qusai Al Abdallah, Kaci DeJarnette, Adela Martin-Vicente, Ashley V. Nywening, Christian DeJarnette, Emily A. Sansevere, Wenbo Ge, Glen E. Palmer, Jarrod R Fortwendel
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 511-526 (2019)
Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit
Externí odkaz:
https://doaj.org/article/a848674584e84a41bcf24b18b8f96f11
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT While the folate biosynthetic pathway has provided a rich source of antibacterial, antiprotozoal, and anticancer therapies, it has not yet been exploited to develop uniquely antifungal agents. Although there have been attempts to develop fun
Externí odkaz:
https://doaj.org/article/7bedfb15049f4488a03cf31477b69091
Autor:
Jeffrey M. Rybak, José F. Muñoz, Katherine S. Barker, Josie E. Parker, Brooke D. Esquivel, Elizabeth L. Berkow, Shawn R. Lockhart, Lalitha Gade, Glen E. Palmer, Theodore C. White, Steve L. Kelly, Christina A. Cuomo, P. David Rogers
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown wh
Externí odkaz:
https://doaj.org/article/57743729eb0c454497ebc0dcd700562d
Autor:
Fabien Cottier, Sarah Sherrington, Sarah Cockerill, Valentina del Olmo Toledo, Stephen Kissane, Helene Tournu, Luisa Orsini, Glen E. Palmer, J. Christian Pérez, Rebecca A. Hall
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Candida albicans is a commensal yeast of the human gut which is tolerated by the immune system but has the potential to become an opportunistic pathogen. One way in which C. albicans achieves this duality is through concealing or exposing ce
Externí odkaz:
https://doaj.org/article/098b1aa947014fae9f1313c46f58a804
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
ABSTRACT A recent study demonstrated that the insertion of poly-adenosine (poly-A) tracts into an open reading frame can suppress expression of the encoded protein in both prokaryotic and eukaryotic species. Furthermore, the degree of suppression is
Externí odkaz:
https://doaj.org/article/34f11c932e704d2a9a2e2bc9015d43de
Autor:
Arturo Luna-Tapia, Christian DeJarnette, Emily Sansevere, Parker Reitler, Arielle Butts, Kirk E. Hevener, Glen E. Palmer
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Calcium is a critically important secondary messenger of intracellular signal transduction in eukaryotes but must be maintained at low levels in the cytoplasm of resting cells to avoid toxicity. This is achieved by several pumps that activel
Externí odkaz:
https://doaj.org/article/6096f121cb3f41459643d166be2241b7
Autor:
Arturo Luna-Tapia, Hubertine M. E. Willems, Josie E. Parker, Hélène Tournu, Katherine S. Barker, Andrew T. Nishimoto, P. David Rogers, Steven L. Kelly, Brian M. Peters, Glen E. Palmer
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Inactivation of sterol Δ5,6-desaturase (Erg3p) in the prevalent fungal pathogen Candida albicans is one of several mechanisms that can confer resistance to the azole antifungal drugs. However, loss of Erg3p activity is also associated with
Externí odkaz:
https://doaj.org/article/e3a04b7a36c249fbbe3ef214803936ec