Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Glen E Cooke"'
Evidence for the role of Epstein Barr Virus infections in the pathogenesis of acute coronary events.
Autor:
Philip F Binkley, Glen E Cooke, Amanda Lesinski, Mackenzie Taylor, Min Chen, Bryon Laskowski, W James Waldman, Maria E Ariza, Marshall V Williams, Deborah A Knight, Ronald Glaser
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54008 (2013)
The role of viral infections in the pathogenesis of atherosclerosis remains controversial largely due to inconsistent detection of the virus in atherosclerotic lesions. However, viral infections elicit a pro-inflammatory cascade known to be atherogen
Externí odkaz:
https://doaj.org/article/871eb5ff61fe46bb95258c40682501d9
Autor:
Udo-Michael Goehring, Klaus F. Rabe, Dirk Bredenbröker, Hassan Lakkis, Peter R. Kowey, Haiyuan Zhu, Paul Rowe, William B. White, Peter M.A. Calverley, Hans Mosberg, Glen E. Cooke
Publikováno v:
Chest. 144:758-765
Background Evaluation of cardiovascular safety for new therapies for COPD is important because of a high prevalence of cardiac comorbidities in the COPD population. Hence, we evaluated the effects of roflumilast, a novel oral phosphodiesterase 4 inhi
Autor:
Glen E. Cooke, Amanda Lesinski, Laura Yamokoski, Jeanette Pohorence Ferguson, Patricia S. Hatton, Philip F. Binkley, Carl V. Leier, Sheetal Hardikar
Publikováno v:
American Heart Journal. 155:69-74
Background This investigation was designed to identify clinical variables associated with recovery of normal ventricular function in patients with dilated cardiomyopathy treated with medical therapy. Recovery of normal ventricular function with medic
Publikováno v:
Pharmacogenomics. 8:1723-1734
Nitric oxide functions as a signaling molecule with a well-established role in vascular homeostasis. It is synthesized from the oxidation of L-arginine by the enzyme, endothelial nitric oxide synthase (eNOS). The eNOS gene has a number of polymorphic
Publikováno v:
Expert Opinion on Drug Safety. 5:815-826
The use of aspirin and clopidogrel in combination has become part of the standard clinical care of patients with coronary artery disease. The use of this combination provides significant benefits compared with the use of aspirin alone in patients wit
Autor:
Mackenzie Taylor, Clifford L. Cua, John R. Hayes, Patricia L. Nash, Patricia Lipowski, Glen E. Cooke, Beth Kossman, Laurie Waldon
Publikováno v:
Congenital Heart Disease. 1:169-174
Objective. Down syndrome patients are at increased risk for developing pulmonary hypertension (PHTN). Nitric oxide (NO) is an important factor for pulmonary vasoreactivity. Various endothelial nitric oxide synthase (eNOS) polymorphisms have been show
Autor:
Pascal J. Goldschmidt-Clermont, Amy K. Ferketich, Melvin L. Moeschberger, Philip F. Binkley, Paul F. Bray, Yiwen Liu-Stratton, Glen E. Cooke, David J. Frid, Raymond D. Magorien
Publikováno v:
Journal of the American College of Cardiology. 47(3):541-546
ObjectivesWe studied the modifier effect of platelet antigen polymorphism (PlA2) on platelet inhibition by acetylsalicylic acid (ASA, i.e., aspirin), clopidogrel, or their combination in patients with coronary heart disease.BackgroundClopidogrel, whe
Publikováno v:
BioTechniques. 34:1068-1072
We present a PCR method for identification of single nucleotide polymorphisms (SNPs), using allele-specific primers designed for selective amplification of each allele. Matching the SNP at the 3′ end of the forward or reverse primer, and additional
Autor:
Harvey D. White, Pascal J. Goldschmidt-Clermont, Jeanette Pohorence, John K. French, Neil S. Van De Water, Yiwen Liu-Stratton, Wanzhen Gao, Mayanna Lund, Timothy Sutton, Glen E. Cooke, Joanne McDowell, Peter Browett, Diane Szymanski
Publikováno v:
American Heart Journal. 145:118-124
Background Although inherited thrombophilias are more common in patients with venous thromboembolism, their influence on the development of myocardial infarction (MI) requires clarification. Methods and Results To determine whether there are increase
Publikováno v:
Statistics in Medicine. 22:1741-1760
The PlA2 polymorphism of the glycoprotein IIIa subunit of the fibrinogen receptor (GPIIb-IIIa) has been reported by some studies to be associated with an increased risk of coronary thrombosis. Following the first paper on the subject in 1996, a large