Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Glen Chew"'
Publikováno v:
The Journal of Immunology. 204:95.19-95.19
The T cell Ig and ITIM domain (TIGIT) receptor is a next generation negative immune checkpoint that is unregulated on exhausted CD8+ T cells in cancer and in chronic HIV-1 infection. TIGIT is currently being pursued in Phase 1 human clinical studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9e311c1ffa28d44e83a2cd3c181773a
https://doi.org/10.4049/jimmunol.204.supp.95.19
https://doi.org/10.4049/jimmunol.204.supp.95.19
Autor:
Kiera Clayton, Matthew Douglas-Vail, A. Rahman, Karyn Medcalf, Irene Xie, Glen Chew, Ravi Tandon, Marion Lanteri, Philip Norris, Steven Deeks, Lishomwa Ndhlovu, Mario Ostrowski
Publikováno v:
The Journal of Immunology. 194:149.5-149.5
Chronic HIV infection results in a loss of HIV-specific CD8+ T cell effector function, termed “exhaustion”, mediated, in part, by the co-inhibitory receptor T cell immunoglobulin mucin domain-3 (Tim-3). Like many other receptors, a soluble form o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a5abf1b693b8119d3f9142982572206
https://doi.org/10.4049/jimmunol.194.supp.149.5
https://doi.org/10.4049/jimmunol.194.supp.149.5
Autor:
Kiera Clayton, Matthew Douglas-Vail, Karyn Medcalf, Glen Chew, Ravi Tandon, Lishomwa Ndhlovu, Mario Ostrowski
Publikováno v:
The Journal of Immunology. 192:74.16-74.16
Chronic Human Immunodeficiency Virus Type-1 (HIV) infection results in a loss of HIV-specific CD8+ T cell effector function, termed “exhaustion”, which is mediated, in-part, by the co-inhibitory receptor T-cell immunoglobulin mucin domain-contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::605c03b3a17ee3c9f7e5d35bc46f7f42
https://doi.org/10.4049/jimmunol.192.supp.74.16
https://doi.org/10.4049/jimmunol.192.supp.74.16
Autor:
Marion Lanteri, Michael Diamond, Jennifer Govero, Amelia Pinto, Jacqueline Law, Glen Chew, Shiquan Wu, Toshiro Niki, Heather Inglis, Mitsuomi Hirashima, Michael Busch, Philip Norris, Lishomwa Ndhlovu
Publikováno v:
The Journal of Immunology. 190:49.22-49.22
After a five-year period of steady annual cases, the 2012 West Nile virus (WNV) season was marked by a 4-fold resurgence with 5387 diagnosed infections, 2734 neuroinvasive cases and 243 deaths. Currently, no treatment or approved human vaccine is ava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e787afb682e56ab69aab53c42491ff0c
https://doi.org/10.4049/jimmunol.190.supp.49.22
https://doi.org/10.4049/jimmunol.190.supp.49.22
Autor:
Bonnie Brayton, Mary Margaret Byron, Glen Chew, Trent Tamate, Timothy Quinn Crawford, Jason Barbour
Publikováno v:
The Journal of Immunology. 190:135.19-135.19
Natural Killer cells are regulated by the polymorphic Killer Ig-like Receptor family. KIR genotype and expression has been associated with HIV-1 disease progression. We developed a high-throughput method to characterize both DNA genotype and RNA expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41a13aa7344a34f2dff8284fa7daccad
https://doi.org/10.4049/jimmunol.190.supp.135.19
https://doi.org/10.4049/jimmunol.190.supp.135.19
Autor:
Ravi Tandon, Tsuyoshi Fujita, Glen Chew, Mary Margaret Byron, Toshiro Niki, Mitsuomi Hirashima, Jason Barbour, Mario Ostrowski, Kiera Clayton, Marion Lanteri, Naoto Ishii, Persephone Borrow, Philip Norris, Frederick Hecht, Lishomwa Ndhlovu
Publikováno v:
The Journal of Immunology. 190:118.6-118.6
Despite successes with antiretroviral therapy, HIV infection continues to be a significant health burden with patients remaining at risk of non-AIDS defining events. The earliest immunological responses induced during HIV infection are key events in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60cadb45662a2efe4e97bfb51f5ea9d8
https://doi.org/10.4049/jimmunol.190.supp.118.6
https://doi.org/10.4049/jimmunol.190.supp.118.6
Publikováno v:
The Journal of Immunology. 188:172.18-172.18
Tim-3 is a regulator of Natural Killer (NK) cell function. The polymorphic killer cell Ig-like receptor (KIR) expressed on NK cells is associated with HIV-1 progression rate. We examined Tim-3 expression level, NK cell function, and KIR genetics in 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::389ea8b5db8f1dc218ebeae7c23e4f06
https://doi.org/10.4049/jimmunol.188.supp.172.18
https://doi.org/10.4049/jimmunol.188.supp.172.18