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Structure elucidation and conformational analysis of gonadotropin releasing hormone and its novel synthetic analogue [Tyr(OMe)5, d-Lys6, Aze9NHEtGnRH: The importance of aromatic clustering in the receptor binding activity

Autor: Dimitris Panagiotopoulos, Hernâni L. S. Maia, Graham J. Moore, D. Pati, Glen Bigam, Thomas Mavromoustakos, M. Keramida, Hamid R. Habibi, John Matsoukas

Publikováno v: European Journal of Medicinal Chemistry. 32:927-940

Summary The conformational properties of gonadotropin releasing hormone (GnRH) in dimethylsulfoxide-d6 were investigated by nuclear Overhauser effect (nOe) enhancement studies and were compared with the conformational properties of its analogue [Tyr(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e23b890fd442d2e8e4ade71799b395e4
https://doi.org/10.1016/s0223-5234(97)89637-7

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Preparation and properties of rhodium(I) and iridium(I) diolefin complexes of heterodifunctional phosphorus–imine chelating ligands and a related iminophosphine. 103Rh NMR parameters of the rhodium complexes obtained via indirect two-dimensional 31P, 103Rh{1H} NMR spectroscopy

Autor: David J. Law, Ronald G. Cavell, Glen Bigam

Publikováno v: Canadian Journal of Chemistry. 73:635-642

Treatment of [M(cod)Cl]2 (M = Rh, Ir) with iminophosphoranophosphine ligands of the type Ph2PQP(Ph2)=NSiMe3 (Q = CH2, CH2CH2, 1,2-C6H4) afforded the new metallacycles [Formula: see text] through elimination of Me3SiCl, ultimately "anchoring" the liga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffb04ded609b432479bf5f4214edee80
https://doi.org/10.1139/v95-082

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Conformational studies of Angiotensin II and analogues in dimethyl sulfoxide by 1H NMR: Lability and intramolecular interactions of the tyrosine hydroxyl and histidine imidazole NH protons

Autor: Raghav Yamdagni, Graham J. Moore, Glen Bigam, John Matsoukas

Publikováno v: Collection of Czechoslovak Chemical Communications. 56:1348-1357

1H NMR studies in dimethyl sulfoxide illustrate that the tyrosine hydroxyl proton and the histidine imidazole NH proton in [Sar1]ANGII and analogues are labile at neutral pH but not at acid pH. This is attributable to intramolecular interactions of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82082b5d84afdb5c7693f42d6d09a8ca
https://doi.org/10.1135/cccc19911348

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I. 1H-NMR studies of [Sar1]angiotensin II conformation by nuclear Overhauser effect spectroscopy in the rotating frame (ROESY): Clustering of the aromatic rings in dimethylsulfoxide

Autor: Graham J. Moore, John Matsoukas, Ning Zhou, Glen Bigam

Publikováno v: Peptides. 11:359-366

The conformational properties of the octapeptide [Sar1]ANG II in dimethylsulfoxide-d6 were investigated by rotating frame nuclear Overhauser effect spectroscopy (ROESY). Interresidue ROESY interactions were observed between Tyr ortho and Phe ring pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983ae9d0e8c3df477d1627b3e25a529b
https://doi.org/10.1016/0196-9781(90)90093-k

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Phase Modulation in APT Spectra for ABX Patterns

Autor: T.T Nakashima, Ronald G. Cavell, R. E. D. McClung, Glen Bigam, C. M. Angelov

Publikováno v: Magnetic Resonance in Chemistry. 35:502-504

Anomalous APT spectra are reported for an organophosphorus compound containing methylene 13C nuclei coupled to two 31P nuclei. Strong coupling effects in these ABX spin systems are shown to account for the anomalous phases and intensities of the APT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::958b1c62cc8aae1c4b61ab84c59d5988
https://doi.org/10.1002/(sici)1097-458x(199708)35:8<502::aid-omr118>3.0.co

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A Ruthenium−Dihydrogen Putative Intermediate in Ketone Hydrogenation

Autor: Carolyn G. Leong, Robin J. Hamilton, Glen Bigam, Steven H. Bergens, Mark Miskolzie

Publikováno v: Journal of the American Chemical Society. 127:4152-4153

The compound fac-[Ru((R)-BINAP)(H)(2-PrOH)3]+ (6) (BINAP = 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) reacts with (R,R)-dpen (dpen = 1,2-diphenylethylenediamine) under H2 at -60 degrees C in 2-PrOH-d8/CD2Cl2 to generate the cationic dihydrogen puta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e260b4bb6c7e25abddf249a0c4627f8
https://doi.org/10.1021/ja043339k

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Evaluation of Mannich bases of 2-arylidene-1,3-diketones versus murine P388 leukemia

Autor: S. K. Raghavan, Jonathan R. Dimmock, Glen Bigam

Publikováno v: European Journal of Medicinal Chemistry. 23:111-117

A number of novel Mannich bases of 2-arylidene-1,3-diketones were shown to have some activity versus P388 lymphocytic leukemia in mice. PMR spectroscopy revealed that most of these compounds underwent intramolecular cyclization in deuterium oxide to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e537c9da2e0bfd22391ae586e8106a4e
https://doi.org/10.1016/0223-5234(88)90182-1

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A high-field proton magnetic resonance and nuclear Overhauser effect study of prostaglandin E2

Autor: Glen Bigam, Gerdy H. M. Aarts, George Kotovych

Publikováno v: Canadian Journal of Chemistry. 58:1577-1583

The proton magnetic resonance (1H nmr) spectrum of prostaglandin E2 (PGE2) in CDCl3 at 400 MHz bas been completely analyzed utilizing homonuclear double resonance, inversion recovery, and nOe difference experiments. The nOe difference experiments are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c9301bfd27517b0a3fb582801d4e352
https://doi.org/10.1139/v80-248

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