Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Glen A, Coburn"'
Autor:
Glen A Coburn, Danielle N Fisch, Sameer M Moorji, Jean-Marc de Muys, Jose D Murga, Dorothy Paul, Kathleen P Provoncha, Yakov Rotshteyn, Amy Q Han, Dapeng Qian, Paul J Maddon, William C Olson
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35351 (2012)
Combinations of direct-acting anti-virals offer the potential to improve the efficacy, tolerability and duration of the current treatment regimen for hepatitis C virus (HCV) infection. Viral entry represents a distinct therapeutic target that has bee
Externí odkaz:
https://doaj.org/article/a9586f6cd3614cdea54f6f4f8141f1da
Autor:
Daniel C. Pevear, Dorothy C. Young, Christopher A. Benetatos, Glen A. Coburn, Susan R. Rippin, Christopher J. Burns, Marc S. Collett, Christopher J. Rizzo, Joel S. Christensen, Tandy L. Draper, Tiejun Gao, John O'Connell, Stephen M. Condon, Kristin Galie, Alison R. Hussey, Srinivas K. Chunduru, Gerry Rhodes, Norman M. Kneteman, Janet A. Gaboury, Tarek S. Mansour, Randy W. Jackson, D. Lorne Tyrrell, Anita Y. M. Howe, Matthew G. LaPorte, Torsten Herbertz
Publikováno v:
ChemMedChem. 3:1508-1515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb243ee1bca7db08b1f5ebe75da0f35
https://doi.org/10.1002/cmdc.200800168
https://doi.org/10.1002/cmdc.200800168
Autor:
Srinivas K. Chunduru, John W. Ellingboe, Huiming Cheng, Boris Feld, John O'Connell, Carl J. Baldick, Matthew W. Olson, Ian J. Thompson, Tarek S. Mansour, Michelle L. Kimberland, Marja van Zeijl, Girija Krisnamurthy, Christopher A. Benetatos, Joel S. Christensen, Dorothy C. Young, Ariamala Gopalsamy, Mark Orlowski, Steve Swanberg, Glen A. Coburn, Megan Thorn, Alfred M. Del Vecchio, Johnathan Bloom, Xiaoqun Jiang, S V Johann, Janis Upeslacis, Marc S. Collett, William P. Gorczyca, Anita Y. M. Howe, Steve Herrmann
Publikováno v:
Antimicrobial Agents and Chemotherapy
A novel nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), [(1 R )-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyano[3,4-b]indol-1-yl] acetic acid (HCV-371), was discovered through high-throughput screening follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3750639fe4a595b533d24806055005
https://doi.org/10.1128/aac.48.12.4813-4821.2004
https://doi.org/10.1128/aac.48.12.4813-4821.2004
Autor:
Glen A. Coburn, Bryan R. Cullen
Publikováno v:
Journal of Antimicrobial Chemotherapy. 51:753-756
This non-specific response to dsRNAleads to global changes in cellular gene expression andapoptosis, masking any specific silencing effect by RNAi inmammalian cells. Recently, however, it was shown that potentand specific gene silencing could be achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b12be4bfe3cf5b42baad48d5cdd609e
https://doi.org/10.1093/jac/dkg166
https://doi.org/10.1093/jac/dkg166
Publikováno v:
Proceedings of the National Academy of Sciences. 99:1888-1893
The Tap protein mediates the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element (CTE). Previously, the structures of individual Tap subdomains,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee85cc87aea80146da1536737cefa7b
https://doi.org/10.1073/pnas.042698599
https://doi.org/10.1073/pnas.042698599
Autor:
Dona N. Ho, Millie M. Georgiadis, Glen A. Coburn, Heather L. Wiegand, Yibin Kang, Bryan R. Cullen
Publikováno v:
Genes & Development. 15:1194-1205
The Tap protein mediates the sequence-specific nuclear export of mRNAs bearing the retroviral constitutive transport element (CTE) and also plays a critical role in the sequence nonspecific export of cellular mRNAs. Previously, we have demonstrated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0c0dd772b3f50c7504afa5c26b38fa
https://doi.org/10.1101/gad.888201
https://doi.org/10.1101/gad.888201
Publikováno v:
Genes & Development. 13:2594-2603
The RNA degradosome is a multiprotein complex required for the degradation of highly structured RNAs. We have developed a method for reconstituting a minimal degradosome from purified proteins. Our results demonstrate that a degradosome-like complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca093738201425cac9b382b274785228
https://doi.org/10.1101/gad.13.19.2594
https://doi.org/10.1101/gad.13.19.2594
Autor:
Glen A. Coburn, George A. Mackie
Publikováno v:
Journal of Molecular Biology. 279:1061-1074
Previous work has implicated poly(A) polymerase I (PAP I), encoded by the pcnB gene, in the decay of a number of RNAs from Escherichia coli. We show here that PAP I does not promote the initiation of decay of the rpsT mRNA encoding ribosomal protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ced9e938e419cc4f2e5a658784697f
https://doi.org/10.1006/jmbi.1998.1842
https://doi.org/10.1006/jmbi.1998.1842
Autor:
Glen A. Coburn, George A. Mackie
Publikováno v:
Journal of Biological Chemistry. 271:15776-15781
The 3'-exonucleolytic decay of the mRNA for ribosomal protein S20 has been reconstituted in vitro using purified RNase II and crude extracts enriched for polynucleotide phosphorylase (PNPase) activity. We show that RNase II can catalyze the degradati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc712b6636144faf21c29b73e1c8fdc
https://doi.org/10.1074/jbc.271.26.15776
https://doi.org/10.1074/jbc.271.26.15776
Autor:
Glen A. Coburn, George A. Mackie
Publikováno v:
Journal of Biological Chemistry. 271:1048-1053
Ribonuclease II (RNase II) is a major exonuclease in Escherichia coli that hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. To understand the role of RNase II in the decay of messenger RNA, a strain overexpressin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c06c9fe2ac8a7d334315c40772a99b
https://doi.org/10.1074/jbc.271.2.1048
https://doi.org/10.1074/jbc.271.2.1048