Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Glen Spraggon"'
Autor:
Martina Maritan, Daniele Veggi, Roberta Cozzi, Lucia Dello Iacono, Erika Bartolini, Paola Lo Surdo, Giulietta Maruggi, Glen Spraggon, Matthew J Bottomley, Enrico Malito
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201922 (2018)
Neisserial heparin binding antigen (NHBA) is one of three main recombinant protein antigens in 4CMenB, a vaccine for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B. NHBA is a surface-exposed lipoprotein
Externí odkaz:
https://doaj.org/article/cee79a5c92024499b9bc57caebc05e1d
Autor:
Elena Menichelli, Bianca J. Lam, Yu Wang, Vivian S. Wang, Jennifer Shaffer, Katrina F. Tjhung, Badry Bursulaya, Truc Ngoc Nguyen, Todd Vo, Phillip B Alper, Christopher S McAllister, David H. Jones, Glen Spraggon, Pierre-Yves Michellys, John Joslin, Gerald F. Joyce, Jeff Rogers
Publikováno v:
Proceedings of the National Academy of Sciences. 119
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using small molecules. While there have been some successes in RNA-targeted small-molecule discovery, a deeper understanding of structure–activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b63539b3423ca34c26d9030ee5bf0b
https://doi.org/10.1073/pnas.2213117119
https://doi.org/10.1073/pnas.2213117119
Autor:
Mari Manuia, Wenshuo Lu, Laura J. Kingsley, Zhiwei Ma, Vicki Zhou, Darbi Witmer, Glen Spraggon, Mu-Yun Gao, Pierre-Yves Michellys, Min Lu, Yong Jia, Matthew McNeill, Sarah Greenblatt, Bender Steven Lee, Andreas Kreusch, Gerald Lelais, Xiaohui He, Victor Nikulin, Mei-Ting Vaillancourt, Christian C. Lee, Jacob R. Haling, John Nelson, Ajay A. Vashisht
Publikováno v:
Journal of Medicinal Chemistry. 64:4857-4869
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Despite the impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b50a3181ddf89b7c66263433d103701a
https://doi.org/10.1021/acs.jmedchem.0c02152
https://doi.org/10.1021/acs.jmedchem.0c02152
Autor:
Glen Spraggon, Smith Jeffrey M, Chianelli Donatella, Advait Nagle, Christian Wiesmann, Xiaodong Liu, Yongping Xie, Richard J. Sciotti, Todd Groessl, Kevin Johnson, Xianzhong Liu, Celine Be, Christopher Thompson, Yin H. Lai, Jan Jiricek, Patrick J Rudewicz, Brandon S. Pybus, Casey J. N. Mathison, Valentina Molteni, Honnappa Srinivas, Richard Glynne, Jaime Ballard, Agnes Biggart, Diana Caridha, Andreas Hein, Ashley Mitchell Berman, Mu-Yun Gao, Lauren C. Davis, Michael Shapiro, Michael Gibney, Yen Liang Chen, Vince Yeh, Fabian K. Eggimann, Badry Bursulaya, Mara Kreishman-Deitrick, Lerario Isabelle K, Fang Liang, Shilpi Khare, Wendy Richmond, Srinivasa P. S. Rao, Frantisek Supek, Tove Tuntland, Alexandre Luneau
Publikováno v:
Journal of Medicinal Chemistry
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37584f6654d3dc34b0710ef1ed444634
https://doi.org/10.1021/acs.jmedchem.0c00499
https://doi.org/10.1021/acs.jmedchem.0c00499
Autor:
Margaret E Brousseau, Kevin B Clairmont, Glen Spraggon, Alec N Flyer, Andrei A Golosov, Philipp Grosche, Jérôme André, Shari Caplan, Guanjing Chen, Li Fan, Raphael Gattlen, Alexander Koch, Ian Lewis, Jingzhou Li, Eugene Liu, Danuta Lubicka, Andreas Marzinzik, Katsumasa Nakajima, David Nettleton, Johannes Ottl, Meihui Pan, Tajesh Patel, Stephanie Pickett, Jennifer Poirier, Patrick C Reid, Xavier Pelle, Vanitha Subramanian, Victoria Vera, Mei Xu, Lihua Yang, Qing Yang, jinghua yu, Guoming Zhu, Lauren G Monovich
Publikováno v:
Circulation. 144
Elevated LDL-C is a major risk factor for atherosclerotic cardiovascular disease, the leading cause of death worldwide. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has pronounced effects on LDL-C levels via its modulation of hepatic LDL rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c41fa5183540594ef99cce950597f62
https://doi.org/10.1161/circ.144.suppl_1.10516
https://doi.org/10.1161/circ.144.suppl_1.10516
Autor:
Marc C Deller, Hope A Johnson, Mitchell D Miller, Glen Spraggon, Marc-André Elsliger, Ian A Wilson, Scott A Lesley
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122512 (2015)
The TM1088 locus of T. maritima codes for two proteins designated TM1088A and TM1088B, which combine to form the cytosolic portion of a putative Trk K+ transporter. We report the crystal structure of this assembly to a resolution of 3.45 Å. The high
Externí odkaz:
https://doaj.org/article/786a0a1d07d640b7a732a35ec3596383
Autor:
Stephen R. Fuhs, Glen Spraggon, Gerald Lelais, Kelly Milliken, Kai Wang, Vincent Brunet, Steve McCloskey, Edgardo Leija, Laura J. Kingsley, Edward Zhou
Publikováno v:
Journal of Molecular Graphics and Modelling. 89:234-241
In drug discovery, structural knowledge of a target enables structure-based design approaches and thereby reduces the time and labor required to develop a therapy. Whilst molecular graphics frameworks coupled with computational analysis are now ubiqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb37c49d2f4b98ba12fef55798ee9ee3
https://doi.org/10.1016/j.jmgm.2019.03.010
https://doi.org/10.1016/j.jmgm.2019.03.010
Autor:
Laura J, Kingsley, Xiaohui, He, Matthew, McNeill, John, Nelson, Victor, Nikulin, Zhiwei, Ma, Wenshuo, Lu, Vicki W, Zhou, Mari, Manuia, Andreas, Kreusch, Mu-Yun, Gao, Darbi, Witmer, Mei-Ting, Vaillancourt, Min, Lu, Sarah, Greenblatt, Christian, Lee, Ajay, Vashisht, Steven, Bender, Glen, Spraggon, Pierre-Yves, Michellys, Yong, Jia, Jacob R, Haling, Gérald, Lelais
Publikováno v:
Journal of medicinal chemistry. 64(8)
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Despite the impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e665e6a49bed89fff37af4eae908565f
https://pubmed.ncbi.nlm.nih.gov/33821636
https://pubmed.ncbi.nlm.nih.gov/33821636
Autor:
Katsumasa Nakajima, David Nettleton, Guoming Zhu, Debra Burdick, Alexander W. Koch, Qing Yang, Glen Spraggon, Margaret E. Brousseau, Guanjing Chen, Lisa Ames, Raphael Gattlen, Flyer Alec, Jennifer Poirier, Jingzhou Li, Mohindra Seepersaud, Dawn Kelly-Sullivan, Stephanie Pickett, Xavier Pelle, Lauren Perry, Raj Chopra, Jakal Amin, Jerome Andre, Danuta Lubicka, Victoria Vera, Philipp Grosche, Patel Tajesh Jayprakash, Ian Lewis, Lihua Yang, Eugene Liu, Andrei Golosov, jinghua yu, Li Fan, Patrick C. Reid, Lauren G. Monovich, Shari L. Caplan, Meihui Pan, Diana Dubiel, Vanitha Subramanian, Kevin B. Clairmont, Johannes Ottl, Mei Xu, Andreas Marzinzik
Publikováno v:
Cell Chemical Biology. 29:249-258.e5
Summary Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b646053b683b9aba0f84b9efef17df
https://doi.org/10.1016/j.chembiol.2021.08.012
https://doi.org/10.1016/j.chembiol.2021.08.012
Autor:
Barbara Nesta, Glen Spraggon, Christopher Alteri, Danilo Gomes Moriel, Roberto Rosini, Daniele Veggi, Sara Smith, Isabella Bertoldi, Ilaria Pastorello, Ilaria Ferlenghi, Maria Rita Fontana, Gad Frankel, Harry L. T. Mobley, Rino Rappuoli, Mariagrazia Pizza, Laura Serino, Marco Soriani
Publikováno v:
mBio, Vol 3, Iss 2 (2012)
ABSTRACT The increasing antibiotic resistance of pathogenic Escherichia coli species and the absence of a pan-protective vaccine pose major health concerns. We recently identified, by subtractive reverse vaccinology, nine Escherichia coli antigens th
Externí odkaz:
https://doaj.org/article/2b6beac9d4a94422bfcf7290d1fa17a3