Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gleice da Graça Rocha"'
Autor:
Kelly Araújo Lúcio, Gleice da Graça Rocha, Leonardo Campos Monção-Ribeiro, Janaina Fernandes, Christina Maeda Takiya, Cerli Rocha Gattass
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28596 (2011)
BackgroundDrug resistance, a process mediated by multiple mechanisms, is a critical determinant for treating lung cancer. The aim of this study is to determine if oleanolic acid (OA), a pentacyclic triterpene present in several plants, is able to cir
Externí odkaz:
https://doaj.org/article/77dbe79e22eb47009878f813b5309a88
Autor:
Cerli Rocha Gattass, Gleice da Graça Rocha, Christina Maeda Takiya, Carollina De Araujo Martins
Publikováno v:
Oncology reports. 42(1)
Prostate cancer (PC) is one of the leading causes of cancer‑related death in the male population worldwide. Mortality of PC is dependent on tumor recurrence and its progression to metastatic disease. We examined the effects of pentacyclic triterpen
Autor:
Cerli Rocha Gattass, Lívia Paes Tavares Pacheco Guimarães, Rafaela Muniz de Queiroz, Carollina De Araujo Martins, Christina Maeda Takiya, Gleice da Graça Rocha
Publikováno v:
Oncology reports. 38(4)
Glioblastoma (GBM), the most aggressive of primary brain tumors, determine short survival and poor quality of life. Therapies used for its treatment are not effective and chemotherapy failure is partially due to multidrug resistance (MDR) mechanisms
Autor:
Cerli Rocha Gattass, Maria Auxiliadora Coelho Kaplan, Rodrigo Rodrigues Oliveira, Gleice da Graça Rocha
Publikováno v:
European Journal of Pharmacology. 741:140-149
ABC transporter overexpression is an important mechanism of multidrug resistance (MDR) and one of the main obstacles to successful cancer treatment. As these proteins actively remove chemotherapeutics from the tumor cells, the pharmacological inhibit
Autor:
Marisol Simões, Gleice da Graça Rocha, Maria Auxiliadora C. Kaplan, Cerli Rocha Gattass, Rodrigo Rodrigues Oliveira
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 6, Pp 6757-6771 (2012)
International Journal of Molecular Sciences
Volume 13
Issue 6
Pages: 6757-6771
International Journal of Molecular Sciences
Volume 13
Issue 6
Pages: 6757-6771
Multidrug resistance (MDR) is considered the main cause of cancer chemotherapy failure and patient relapse. The active drug efflux mediated by transporter proteins of the ABC (ATP-binding cassette) family is the most investigated mechanism leading to
Autor:
Cerli Rocha Gattass, Maria Auxiliadora Coelho Kaplan, Rodrigo Rodrigues Oliveira, Marisol Simões, Gleice da Graça Rocha
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 6, Pp 6757-6771 (2012)
Multidrug resistance (MDR) is considered the main cause of cancer chemotherapy failure and patient relapse. The active drug efflux mediated by transporter proteins of the ABC (ATP-binding cassette) family is the most investigated mechanism leading to
Autor:
Lívia Paes Tavares Pacheco Guimarães, Celuta S. Alviano, Rafaela Muniz de Queiroz, Christina Maeda Takiya, Cerli Rocha Gattass, Daniela S. Alviano, Arie Fitzgerald Blank, Gleice da Graça Rocha
Publikováno v:
Cancer investigation. 32(6)
Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and in
Autor:
Maria Auxiliadora Coelho Kaplan, Gleice da Graça Rocha, Marisol Simões, Rodrigo Rodrigues Oliveira, Cerli Rocha Gattass
Publikováno v:
Investigational new drugs. 30(1)
Chronic Myeloid Leukemia (CML) is a potentially fatal stem-cell cancer. P-glycoprotein (P-gp/ABCB1) activity has been described as a relevant factor in the chemotherapeutic failure and correlated to a poor prognosis in these malignancies. In the pres
Autor:
Marisol Simões, Maria Auxiliadora Coelho Kaplan, Kelly Araujo Lucio, Gleice da Graça Rocha, Cerli Rocha Gattass, Rodrigo Rodrigues de Oliveira
Publikováno v:
ChemInform. 39
The cytotoxicity of four triterpenoids, euscaphic acid (1), tormentic acid (2), 2α-acetyl tormentic acid (3), and 3β-acetyl tormentic acid (4), isolated from the roots of Cecropia lyratiloba (Moraceae) by countercurrent chromatography, was evaluate
Autor:
Cerli Rocha Gattass, Kelly Araujo Lucio, Marisol Simões, Rodrigo Rodrigues de Oliveira, Maria Auxiliadora Coelho Kaplan, Gleice da Graça Rocha
Publikováno v:
Bioorganicmedicinal chemistry. 15(23)
The cytotoxicity of four triterpenoids, euscaphic acid (1), tormentic acid (2), 2alpha-acetyl tormentic acid (3), and 3beta-acetyl tormentic acid (4), isolated from the roots of Cecropia lyratiloba (Moraceae) by countercurrent chromatography, was eva