Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gleb Simanov"'
Autor:
Fred E. Fregoso, Trevor van Eeuwen, Gleb Simanov, Grzegorz Rebowski, Malgorzata Boczkowska, Austin Zimmet, Alexis M. Gautreau, Roberto Dominguez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The Arp2/3 complex inhibitor Arpin controls cell migration by interrupting a feedback loop involving Rac-WAVE-Arp2/3 complex Here, the authors use structural, biochemical, and cellular studies to reveal Arpin’s mechanism of inhibition.
Externí odkaz:
https://doaj.org/article/6a8063234c014575b26daa0160bba64f
Autor:
Artem I. Fokin, Arthur Boutillon, John James, Laura Courtois, Sophie Vacher, Gleb Simanov, Yanan Wang, Anna Polesskaya, Ivan Bièche, Nicolas B. David, Alexis M. Gautreau
The Rac1-WAVE-Arp2/3 pathway pushes the plasma membrane by polymerizing branched actin at the cell cortex and thereby powering membrane protrusions that mediate cell migration. Here, using knock-down (KD) or knock-out (KO), we combine the inactivatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a4d9bbd288021b029e490dbc74ef1c
https://doi.org/10.1101/2023.05.13.540631
https://doi.org/10.1101/2023.05.13.540631
Publikováno v:
Trends Cell Biol
Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing forces that drive cellular processes ranging from membrane remodeling to cell an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92a57d57ae8003324defb6d6367c54e
https://doi.org/10.1016/j.tcb.2021.10.006
https://doi.org/10.1016/j.tcb.2021.10.006
Autor:
Fred E. Fregoso, Alexis M. Gautreau, Roberto Dominguez, Grzegorz Rebowski, Malgorzata Boczkowska, Trevor van Eeuwen, Gleb Simanov, Austin Zimmet
Positive feedback loops involving signaling and actin assembly factors mediate the formation and remodeling of branched actin networks in processes ranging from cell and organelle motility to mechanosensation. The Arp2/3 complex inhibitor Arpin contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce9fa0c9d0f2f81fcd6634f72e44b0ba
https://doi.org/10.1101/2021.10.30.466598
https://doi.org/10.1101/2021.10.30.466598
Autor:
Artem I. Fokin, Jacqueline Cherfils, Alexis Gautreau, Gleb Simanov, Valérie Campanacci, Ksenia Oguievetskaia, Irene Dang
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (8), ⟨10.3390/ijms22084115⟩
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 4115, p 4115 (2021)
International Journal of Molecular Sciences, MDPI, 2021, 22 (8), ⟨10.3390/ijms22084115⟩
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 4115, p 4115 (2021)
During cell migration, protrusion of the leading edge is driven by the polymerization of Arp2/3-dependent branched actin networks. Migration persistence is negatively regulated by the Arp2/3 inhibitory protein Arpin. To better understand Arpin regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da8861e634721eb1ffa38651171fe0c
https://doi.org/10.3390/ijms22084115
https://doi.org/10.3390/ijms22084115