Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gleb Kuznetsov"'
Autor:
Daniel B. Goodman, Gleb Kuznetsov, Marc J. Lajoie, Brian W. Ahern, Michael G. Napolitano, Kevin Y. Chen, Changping Chen, George M. Church
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-7 (2017)
Abstract Inexpensive DNA sequencing and advances in genome editing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and microbial genome engineering. We describe Millstone, a web-based platform that automat
Externí odkaz:
https://doaj.org/article/8459d7a4fb44406887544a589bea7343
Autor:
Gleb Kuznetsov, Daniel B. Goodman, Gabriel T. Filsinger, Matthieu Landon, Nadin Rohland, John Aach, Marc J. Lajoie, George M. Church
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract We present a method for identifying genomic modifications that optimize a complex phenotype through multiplex genome engineering and predictive modeling. We apply our method to identify six single nucleotide mutations that recover 59% of the
Externí odkaz:
https://doaj.org/article/6d97b73a33114393895f5b605eecfd99
Autor:
Gleb Kuznetsov, TATYANA GUDKOVA
Publikováno v:
MIR (Modernization. Innovation. Research). 13:476-493
Purpose: this article is aimed at identifying the economic effects arising out of the integration of companies within the framework of the digital business ecosystem.Methods: the article is based on the concept of the evolution of organizational syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc455c5e60248fff4d56aa5f152490a
https://doi.org/10.18184/2079-4665.2022.13.3.476-493
https://doi.org/10.18184/2079-4665.2022.13.3.476-493
Publikováno v:
Vestnik of Northern (Arctic) Federal University. Series "Humanitarian and Social Sciences". :146-151
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::622a6317922dd29c7585ade2fc603d25
https://doi.org/10.17238/issn2227-6564.2017.1.146
https://doi.org/10.17238/issn2227-6564.2017.1.146
Autor:
Nili Ostrov, Julie E. Norville, Marc J. Lajoie, Natalie Cervantes, Marc Güell, Daniel B. Goodman, Michael G. Napolitano, Barry L. Wanner, Nicholas Conway, Minerva Zhou, Kerry Singh, Matthieu Landon, Gleb Kuznetsov, Ellen Shrock, Mark Moosburner, George M. Church, Benjamin W. Pruitt, Cameron L. Gardner, Alexandra Gonzales, Jun Teramoto, Gary Tyree
Publikováno v:
Science. 353:819-822
Recoding and repurposing genetic codons By recoding bacterial genomes, it is possible to create organisms that can potentially synthesize products not commonly found in nature. By systematic replacement of seven codons with synonymous alternatives fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7459dab55a304473ce13aaff8ac09c
https://doi.org/10.1126/science.aaf3639
https://doi.org/10.1126/science.aaf3639
Autor:
Pierce Ogden, Nicholas Conway, George M. Church, Ryan P. Adams, Gleb Kuznetsov, Surojit Biswas
Proteins—molecular machines that underpin all biological life—are of significant therapeutic and industrial value. Directed evolution is a high-throughput experimental approach for improving protein function, but has difficulty escaping local max
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d18c9a74c357b85aaab43421457bca
Autor:
George M. Church, Daniel B. Goodman, Changping Chen, Kevin Y. Chen, Michael G. Napolitano, Brian W. Ahern, Marc J. Lajoie, Gleb Kuznetsov
Publikováno v:
Genome Biology
Genome Biology, Vol 18, Iss 1, Pp 1-7 (2017)
Genome Biology, Vol 18, Iss 1, Pp 1-7 (2017)
Inexpensive DNA sequencing and advances in genome editing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and microbial genome engineering. We describe Millstone, a web-based platform that automates genoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c923402b054d47a0567154566fbb0234
https://doi.org/10.1186/s13059-017-1223-1
https://doi.org/10.1186/s13059-017-1223-1
Autor:
Marc J. Lajoie, Matthieu Landon, Gleb Kuznetsov, Nadin Rohland, Daniel B. Goodman, John Aach, Gabriel T. Filsinger, George M. Church
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-12 (2017)
Genome Biology
Genome Biology
Optimization of complex phenotypes in engineered microbial strains has traditionally been accomplished by laboratory evolution. However, only a subset of the resulting mutations may affect the phenotype of interest and many others may have unintended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bc47ae54825b6670bc1448052fdbd3
Autor:
Matthieu Landon, Daniel B. Goodman, Farren J. Isaacs, Joshua A. Mosberg, Marc J. Lajoie, Oscar Vargas-Rodriguez, Michael G. Napolitano, Lakshmi Narasimhan Govindarajan, Christopher J. Gregg, Dieter Söll, George M. Church, Gleb Kuznetsov
Publikováno v:
Proceedings of the National Academy of Sciences. 113
The degeneracy of the genetic code allows nucleic acids to encode amino acid identity as well as non-coding information for gene regulation and genome maintenance. The rare arginine codons AGA and AGG (AGR) present a case study in codon choice, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e27d5e6cc4a4c6b3e91fa5a4e3df766
https://doi.org/10.1073/pnas.1605856113
https://doi.org/10.1073/pnas.1605856113
Autor:
Michael T. Mee, Barry L. Stoddard, Daniel J. Mandell, Marc J. Lajoie, George M. Church, Ryo Takeuchi, Gleb Kuznetsov, Julie E. Norville, Christopher J. Gregg
Publikováno v:
Nature. 527:264-264
Nature 518, 55–60 (2015); doi:10.1038/nature14121 In the interests of transparency, we wish to amend the competing financial interests of this Article to read: “Harvard has filed a provisional patent application. G.M.C. is a founder of Enevolv In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b66dd0d9b68eda4f372b3b5b6cb820
https://doi.org/10.1038/nature15536
https://doi.org/10.1038/nature15536