Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling

Autor: Aurelie Nguyen Dinh Cat, Glaucia E. Callera, Malou Friederich-Persson, Ana Sanchez, Maria Gabriela Dulak-Lis, Sofia Tsiropoulou, Augusto C. Montezano, Ying He, Ana M. Briones, Frederic Jaisser, Rhian M. Touyz

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Abstract Activation of aldosterone/mineralocorticoid receptors (MR) has been implicated in vascular dysfunction of diabetes. Underlying mechanisms are elusive. Therefore, we investigated the role of Rho kinase (ROCK) in aldosterone/MR signaling and v

Externí odkaz: https://doaj.org/article/1cbc4ec98c8b49dfb0ee07f4993edd82

Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase

Autor: Aikaterini Anagnostopoulou, Tayze T. Antunes, Ana Sánchez, Augusto C. Montezano, Maria Dulak-Lis, Sofia Tsiropoulou, Frederic Jaisser, Ying He, Rhian M. Touyz, Aurelie Nguyen Dinh Cat, Glaucia E. Callera

Publikováno v: Diabetes. 65:2392-2403

Mineralocorticoid receptor (MR) expression is increased in adipose tissue from obese individuals and animals. We previously demonstrated that adipocyte-MR overexpression (Adipo-MROE) in mice is associated with metabolic changes. Whether adipocyte MR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e2bf5c2d1823760fb3ff94a7a500968
https://doi.org/10.2337/db15-1627

Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress

Autor: Thiago, Bruder-Nascimento, Glaucia E, Callera, Augusto C, Montezano, Eric J, Belin de Chantemele, Rita C, Tostes, Rhian M, Touyz

Publikováno v: Life sciences

Vascular inflammatory responses play an important role in several cardiovascular diseases. Of the many pro-inflammatory vasoactive factors implicated in this process, is aldosterone, an important mediator of vascular oxidative stress. Statins, such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec5a6b2e95aba7c12c93509cd2486fc5
https://pubmed.ncbi.nlm.nih.gov/30721707

Assessment of Caveolae/Lipid Rafts in Isolated Cells

Autor: Glaucia E. Callera, Rhian M. Touyz, Thiago Bruder-Nascimento

Publikováno v: Hypertension ISBN: 9781493966233

This chapter outlines protocols to evaluate protein localization, recruitment or phosphorylation levels in cholesterol/sphingolipids-enriched cell membrane domains and recommends experimental designs with pharmacological tolls to evaluate potential c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a7f2c3215a76d248267f09ccd19b42b
https://doi.org/10.1007/978-1-4939-6625-7_20

Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries

Autor: Carlos R. Tirapelli, Janaina A. Simplicio, Rita de Cássia Tostes, Glaucia E. Callera, Rhian M. Touyz, Camila A. Pereira, Ulisses V. Hipólito, Gabriel T. do Vale

Publikováno v: Arquivos Brasileiros de Cardiologia, Volume: 107, Issue: 5, Pages: 427-436, Published: 27 OCT 2016
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Arquivos Brasileiros de Cardiologia, Iss 0
Arquivos Brasileiros de Cardiologia
Arquivos Brasileiros de Cardiologia v.107 n.5 2016
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC

Background: The mechanism underlying the vascular dysfunction induced by ethanol is not totally understood. Identification of biochemical/molecular mechanisms that could explain such effects is warranted. Objective: To investigate whether acute ethan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f815f8512f4f48757570efd8a54501b5
https://doi.org/10.5935/abc.20160147