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Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.

Autor: Dolman NP; Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom., More JC, Alt A, Knauss JL, Pentikäinen OT, Glasser CR, Bleakman D, Mayer ML, Collingridge GL, Jane DE

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2007 Apr 05; Vol. 50 (7), pp. 1558-70. Date of Electronic Publication: 2007 Mar 10.