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Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture.

Autor: Glass MR; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Waxman EA; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Yamashita S; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA., Lafferty M; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Beltran AA; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Farah T; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Patel NK; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Singla R; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Matoba N; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ahmed S; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Srivastava M; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Drake E; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Davis LT; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Yeturi M; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sun K; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Love MI; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hashimoto-Torii K; Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA; Departments of Pediatrics, and Pharmacology & Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA., French DL; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Stein JL; UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: jason_stein@med.unc.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2024 Sep 10; Vol. 19 (9), pp. 1351-1367. Date of Electronic Publication: 2024 Aug 22.

Donor perspectives on informed consent and use of biospecimens for brain organoid research.

Autor: MacDuffie KE; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA; Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, WA, USA. Electronic address: kate.macduffie@seattlechildrens.org., Stein JL; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Doherty D; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Jayadev S; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA., Girault JB; Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Emmons KA; Department of Speech & Hearing Sciences, University of Washington, Seattle, WA, USA., Glass MR; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Dempsey JC; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Marrus N; Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Botteron KN; Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Dager SR; Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA., Estes AM; Department of Speech & Hearing Sciences, University of Washington, Seattle, WA, USA., Piven J; Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Wilfond BS; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA; Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, WA, USA.

Publikováno v: Stem cell reports [Stem Cell Reports] 2023 Jul 11; Vol. 18 (7), pp. 1389-1393. Date of Electronic Publication: 2023 Jun 22.