Výsledky vyhledávání - "Glaspy John A"

Akademický článek

Safety profile and pharmacokinetic analyses of the anti-CTLA4 antibody tremelimumab administered as a one hour infusion

Autor: Ribas Antoni, Chesney Jason A, Gordon Michael S, Abernethy Amy P, Logan Theodore F, Lawson David H, Chmielowksi Bartosz, Glaspy John A, Lewis Karl, Huang Bo, Wang Erjian, Hsyu Poe-Hirr, Gomez-Navarro Jesus, Gerhardt Diana, Marshall Margaret A, Gonzalez Rene

Publikováno v: Journal of Translational Medicine, Vol 10, Iss 1, p 236 (2012)

Abstract Background CTLA4 blocking monoclonal antibodies provide a low frequency but durable tumor responses in patients with metastatic melanoma, which led to the regulatory approval of ipilimumab based on two randomized clinical trials with overall

Externí odkaz: https://doaj.org/article/77e605fdeb0e419fa7f1fd10b3d924a9

Zobrazit plný text záznamu

Akademický článek

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

Autor: Recio Juan A, Glaspy John A, Ng Charles, Sazegar Hooman, Matsunaga Doug, Guo Deliang, Attar Narsis, von Euw Erika, Niehr Franziska, Lo Roger S, Mischel Paul S, Comin-Anduix Begonya, Ribas Antoni

Publikováno v: Journal of Translational Medicine, Vol 9, Iss 1, p 76 (2011)

Abstract Background A molecular linkage between the MAPK and the LKB1-AMPK energy sensor pathways suggests that combined MAPK oncogene inhibition and metabolic modulation of AMPK would be more effective than either manipulation alone in melanoma cell

Externí odkaz: https://doaj.org/article/07f1a3c842bf4d638c59891157f0e629

Zobrazit plný text záznamu

Akademický článek

Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma

Autor: Hernandez Jackie, Oseguera Denise K, Glaspy John A, Prieto Victor G, Rodriguez Maria, Richards Jon M, Brown Charles K, Hersh Evan M, Lee Sun, Camacho Luis H, Ribas Antoni, Villanueva Arturo, Chmielowski Bartosz, Mitsky Peggie, Bercovici Nadège, Wasserman Ernesto, Landais Didier, Ross Merrick I

Publikováno v: Journal of Translational Medicine, Vol 8, Iss 1, p 89 (2010)

Abstract Background Several single center studies have provided evidence of immune activation and antitumor activity of therapeutic vaccination with dendritic cells (DC) in patients with metastatic melanoma. The efficacy of this approach in patients

Externí odkaz: https://doaj.org/article/899911fac4964a80a9c74076a479efa1

Zobrazit plný text záznamu

Akademický článek

Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma

Autor: Gualberto Antonio, Straatsma Bradley R, Villanueva Arturo, Seja Elisabeth, Bulanhagui Cecile A, Bozon Viviana A, Camacho Luis H, de la Rocha Pilar, Algazi Alain, Jalil Jason, Lee Yohan, Comin-Anduix Begoña, Economou James S, Glaspy John A, Gomez-Navarro Jesus, Ribas Antoni

Publikováno v: Journal of Translational Medicine, Vol 6, Iss 1, p 22 (2008)

Abstract Background CTLA4-blocking antibodies induce tumor regression in a subset of patients with melanoma. Analysis of immune parameters in peripheral blood may help define how responses are mediated. Methods Peripheral blood from HLA-A*0201-positi

Externí odkaz: https://doaj.org/article/54dbb06b273b4dbba6e652104a38297d

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání