Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Gladys Teitelman"'
Autor:
Gladys Teitelman
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 70(10)
The observation that the two active forms of proprotein convertase 1/3 (PC1/3) were differentially expressed in beta cells of normal islets raised the possibility that this heterogeneity is lost during type 1 diabetes (T1D) progression. To test this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec84a240848f0bfb581d2285f746748
https://pubmed.ncbi.nlm.nih.gov/36341551
https://pubmed.ncbi.nlm.nih.gov/36341551
Autor:
Gladys Teitelman
Publikováno v:
J Histochem Cytochem
In pancreatic beta cells, proinsulin (ProIN) undergoes folding in endoplasmic reticulum/Golgi system and is translocated to secretory vesicles for processing into insulin and C-peptide by the proprotein convertases (PC)1/3 and PC2, and carboxypeptida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca6da5c90a001cb0d9ee454d7353717
https://europepmc.org/articles/PMC7534102/
https://europepmc.org/articles/PMC7534102/
Autor:
Gladys Teitelman
Publikováno v:
J Histochem Cytochem
Although there is evidence indicating transcriptional and functional heterogeneity in human beta cells, it is unclear whether this heterogeneity extends to the expression level of the enzymes that process proinsulin to insulin in beta cells. To addre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067e969365711abacaa71593c23c4655
https://pubmed.ncbi.nlm.nih.gov/30759032
https://pubmed.ncbi.nlm.nih.gov/30759032
Publikováno v:
Endocrinology. 153:3076-3088
Glucagon like peptide-1 (GLP-1) and GLP-2 are hormones secreted by intestinal L cells that stimulate glucose-dependent insulin secretion and regulate intestinal growth, respectively. Mice with deletion of the glucagon receptor (Gcgr) have high levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32567e386535a2a8f243eb8e4106787
https://doi.org/10.1210/en.2012-1120
https://doi.org/10.1210/en.2012-1120
Publikováno v:
Endocrinology. 151:520-528
Whereas it is believed that the pancreatic duct contains endocrine precursors, the presence insulin progenitor cells residing in islets remain controversial. We tested whether pancreatic islets of adult mice contain precursor β-cells that initiate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c5a8381a5349a981b5265c6b4df430
https://doi.org/10.1210/en.2009-0992
https://doi.org/10.1210/en.2009-0992
Publikováno v:
Biochemical and Biophysical Research Communications. 358:209-214
Connective tissue growth factor (CTGF) is a profibrotic factor shown to induce extracellular matrix production and angiogenesis, two processes involved in the development of diabetic retinopathy (DR). In this study we tested the effect of a recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83f946cd36fb57fd1ace8b46ee9e70e
https://doi.org/10.1016/j.bbrc.2007.04.109
https://doi.org/10.1016/j.bbrc.2007.04.109
Autor:
Mamdouh H. Kedees, Gladys Teitelman
We used cre-lox technology to test whether the inducible expression of Cre minimize the deleterious effect of the enzyme on beta cell function. We studied mice in which Cre is linked to a modified estrogen receptor (ER), and its expression is control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ec78f2cfffa4958e9b6c7476f33810
https://europepmc.org/articles/PMC4319030/
https://europepmc.org/articles/PMC4319030/
Publikováno v:
Molecular and Cellular Endocrinology. 233:1-13
During pregnancy, pancreatic beta cells undergo changes that are probably due to an increase in the lactogenic hormones prolactin (PRL) and placental lactogen (PL). Since the transcription factor PDX-1 is involved in the regulation of the beta cell f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04310120de51d4423dd73e999d77a7ff
https://doi.org/10.1016/j.mce.2005.02.001
https://doi.org/10.1016/j.mce.2005.02.001
Autor:
Gladys Teitelman
Publikováno v:
Endocrinology. 155(4)
Incretins are hormones released by gut enteroendocrine cells in response to nutrient ingestion that regulate circulating glucose levels. One member of the incretin family is the glucagon-like peptide-1 (GLP-1), which is secreted by intestinal L cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c944383074b047aa065c22f70dfa05
https://pubmed.ncbi.nlm.nih.gov/24654830
https://pubmed.ncbi.nlm.nih.gov/24654830
Autor:
L. C. King, Christopher V.E. Wright, Gladys Teitelman, Roland Stein, A. Fernandes, Yelena Guz
Publikováno v:
Endocrinology. 138:1750-1762
The ability of the adult pancreas to generate new insulin (β) cells has been controversial because of difficulties in unequivocally identifying the precursor population. We recently determined that β cells were generated during development from pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::effe656bdcd3f1b167a0c2b04bd7e88d
https://doi.org/10.1210/endo.138.4.5049
https://doi.org/10.1210/endo.138.4.5049