Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gladys L. Caldeira"'
Autor:
Gladys L. Caldeira, R. P. Gouveia, Carlos A. V. Barreto, João Peça, Mohamed Edfawy, Ana Luísa Carvalho, Nuno Beltrão, A. S. Inacio, Joana R. Guedes, R. Macedo, B. Cruz, Susana R. Louros, Irina S. Moreira, Tiago Rondão, M. V. Rodrigues
Publikováno v:
Molecular Psychiatry. 27:2457-2469
Mutations linked to neurodevelopmental disorders, such as intellectual disability (ID), are frequently found in genes that encode for proteins of the excitatory synapse. Transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b388ee4abf1d00e2ec4917aa9ca444
https://doi.org/10.1038/s41380-022-01487-w
https://doi.org/10.1038/s41380-022-01487-w
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors. Homeostatic scaling down
Externí odkaz:
https://doaj.org/article/194cba42f34245cd9825a9ac4718fa5e
Autor:
João Peça, Mário Jorge da Silva Carvalho, Xian Gao, Pedro A. Ferreira, Ana L. Cardoso, Gladys L. Caldeira, Mariana Laranjo, Joana R. Guedes, Guoping Feng, Ana Luísa Carvalho, Dongqing Wang, Mohamed Edfawy, Marta I Pereira, Lara O. Franco
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Autism spectrum disorder (ASD) is characterized by dysfunction in social interactions, stereotypical behaviours and high co-morbidity with intellectual disability. A variety of syndromic and non-syndromic neurodevelopmental disorders have been connec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4173af7a4bb1055c835242dd2d888c4
http://link.springer.com/article/10.1038/s41467-019-09382-9
http://link.springer.com/article/10.1038/s41467-019-09382-9
Autor:
Michael R. Hayden, Mário N. Laço, Gladys L. Caldeira, A. Cristina Rego, Luana Naia, Ana Oliveira, Tatiana R. Rosenstock, Sofia I. Oliveira-Sousa, Catarina Carmo, Catarina R. Oliveira
Publikováno v:
Molecular Neurobiology. 54:5385-5399
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. Both activation and inhibition of SIRT1 were previously shown to ameliorate neuropathological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7013bab31020ea6c6771b55f8a26802
https://doi.org/10.1007/s12035-016-0048-3
https://doi.org/10.1007/s12035-016-0048-3
Publikováno v:
Current opinion in neurobiology. 57
Growing evidence implicates synaptic proteins in the pathogenesis of neuropsychiatric disorders such as autism spectrum disorder (ASD), intellectual disability (ID) and schizophrenia. In fact, mutations in genes encoding synaptic proteins are enriche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57db707a30b33e3e0fda132c6ba710dd
https://pubmed.ncbi.nlm.nih.gov/30743178
https://pubmed.ncbi.nlm.nih.gov/30743178
Autor:
Isabel Santana, Catarina R. Oliveira, Gladys L. Caldeira, Ildete L. Ferreira, Sandra I. Mota, Inês Baldeiras, Liliana Letra, Ana Cristina Rego, Rui Costa, Carmela Padovano, Ana Catarina R.G. Fonseca, Catarina Cunha, Cláudia Pereira
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1852:1428-1441
Oxidative stress and endoplasmic reticulum (ER) stress have been associated with Alzheimer's disease (AD) progression. In this study we analyzed whether oxidative stress involving changes in Nrf2 and ER stress may constitute early events in AD pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b089903ae0cd54544a6e84f65ce8fbc4
https://doi.org/10.1016/j.bbadis.2015.03.015
https://doi.org/10.1016/j.bbadis.2015.03.015
Publikováno v:
Journal of Alzheimer's disease : JAD. 34(1)
Alzheimer's disease (AD) is the major cause of dementia in the world. Abnormal extracellular accumulation of amyloid-β (Aβ) peptide and tau hyperphosphorylation, forming neurofibrillary tangles in the brain, are hallmarks of the disease. Oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aa3a90e7c58a40db3c4c3d30fb6bb6
https://pubmed.ncbi.nlm.nih.gov/23364141
https://pubmed.ncbi.nlm.nih.gov/23364141
Publikováno v:
Frontiers in Molecular Neuroscience; 9/13/2018, pN.PAG-N.PAG, 13p
Autor:
Aman B Upaganlawar
Free radicals are continuously produced in cells as a part of normal cellular function. However, excess generation of free radicals plays a critical role in the pathophysiology of many disease conditions, especially cancer, atherosclerosis, Alzheimer
