Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Gladys J Keitany"'
Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein
Autor:
Gladys J. Keitany, Karen S. Kim, Akshay T. Krishnamurty, Brian D. Hondowicz, William O. Hahn, Nicholas Dambrauskas, D. Noah Sather, Ashley M. Vaughan, Stefan H.I. Kappe, Marion Pepper
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3193-3205 (2016)
Many current malaria vaccines target the pre-erythrocytic stage of infection in the liver. However, in malaria-endemic regions, increased blood stage exposure is associated with decreased vaccine efficacy, thereby challenging current vaccine efforts.
Externí odkaz:
https://doaj.org/article/c696799bd66349bbb1b8efcefd3d4b73
Autor:
Harold Obiakor, Shaji Daniel, Justin Doritchamou, Andrew V. Oleinikov, Tracy Saveria, Robert Morrison, Nicholas J. MacDonald, Bethany J Jenkins, Gladys J. Keitany, David L. Narum, Atis Muehlenbachs, Sanjay A. Desai, Jean-Philippe Semblat, Marissa Vignali, Benoit Gamain, Michal Fried, Patrick E. Duffy
Publikováno v:
J Infect Dis
Background Plasmodium falciparum-infected red blood cells (iRBCs) bind and sequester in deep vascular beds, causing malaria-related disease and death. In pregnant women, VAR2CSA binds to chondroitin sulfate A (CSA) and mediates placental sequestratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07f57b79de22164210187b9c5c5b366
https://doi.org/10.1093/infdis/jiab550
https://doi.org/10.1093/infdis/jiab550
Autor:
Brandon K Sack, Gladys J Keitany, Ashley M Vaughan, Jessica L Miller, Ruobing Wang, Stefan H I Kappe
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004855 (2015)
Malaria, caused by Plasmodium parasite infection, continues to be one of the leading causes of worldwide morbidity and mortality. Development of an effective vaccine has been encumbered by the complex life cycle of the parasite that has distinct pre-
Externí odkaz:
https://doaj.org/article/836dfd21064b42c5bf9511446f9521a3
Autor:
Lin Chen, Gladys J Keitany, Xiaohong Peng, Claire Gibson, Isaac Mohar, Marissa Vignali, Ian N Crispe, Fusheng Huang, Ruobing Wang
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102225 (2014)
Pre-erythrocytic malaria vaccines, including those based on whole-parasite approaches, have shown protective efficacy in animal and human studies. However few pre-erythocytic antigens other than the immunodominant circumsporozoite protein (CSP) have
Externí odkaz:
https://doaj.org/article/173fd53b9ab24a7db2f58966dd849f58
Autor:
Christopher D. Thouvenel, Silvia Portugal, Eric M. Lynch, Mary F. Fontana, Marie Pancera, Suruchi Singh, Jason Netland, Kennidy K Takehara, Marion Pepper, Neil P. King, Peter D. Crompton, Gladys J. Keitany, Yu Chen, Carole A. Long, Akshay T. Krishnamurty, Kazutoyo Miura, David J. Rawlings, Marcos C. Miranda, Justin M. Kollman
Publikováno v:
The Journal of Experimental Medicine
Thouvenel et al. isolate BCR sequences from Plasmodium-specific IgM+ human memory B cells, expressing them as both IgM and IgG molecules. Multimerization confers superior antigen binding and parasite restriction, highlighting an important role for me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05081f2f23d9d75c33be1816f0e6e347
https://doi.org/10.1084/jem.20200942
https://doi.org/10.1084/jem.20200942
Publikováno v:
European Journal of Immunology. 48:80-86
CD4+ tissue resident cells are an important first line of defense against viral infections in the lungs and are critical for promoting the localization of lung resident CD8+ T cells. However, relatively little is known about the signaling programs re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f6315943cb2adf602a5ce52f01f076f
https://doi.org/10.1002/eji.201746928
https://doi.org/10.1002/eji.201746928
Autor:
Tracy Saveria, Patrick E. Duffy, Andrew V. Oleinikov, Richa Chaturvedi, Joe Lograsso, Michal Fried, Gladys J. Keitany, Kathryn Wiliamson
Publikováno v:
Infection and Immunity. 81:1031-1039
Placental malaria (PM) is characterized by infected erythrocytes (IEs) that selectively bind to chondroitin sulfate A (CSA) and sequester in placental tissue. Variant surface antigen 2-CSA (VAR2CSA), a Plasmodium falciparum erythrocyte membrane prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0dd685726d50855f80423c54350eea
https://doi.org/10.1128/iai.00978-12
https://doi.org/10.1128/iai.00978-12
Autor:
Peter D. Crompton, David J. Rawlings, Gladys J. Keitany, Akshay T. Krishnamurty, Anthony A. Holder, Silvia Portugal, Marion Pepper, Karen S. Kim, Christopher D. Thouvenel
Publikováno v:
Immunity
Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B cells (MBC). Recent studies of MBC development and function after protein immunization have uncovered significant MBC heterogeneit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feacc5b835092312f797731df313f874
https://hdl.handle.net/21.11116/0000-0006-9EBE-321.11116/0000-0006-9EC0-F
https://hdl.handle.net/21.11116/0000-0006-9EBE-321.11116/0000-0006-9EC0-F
Publikováno v:
Journal of Biological Chemistry. 282:34299-34305
The bacterial pathogen Vibrio parahemeolyticus manipulates host signaling pathways during infections by injecting type III effectors. One of these effectors, Vibrio outer protein A (VopA), inhibits MAPK signaling via a novel mechanism, distinct from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37aef3c34ea8d1c989cc7fdd47aca141
https://doi.org/10.1074/jbc.m706970200
https://doi.org/10.1074/jbc.m706970200
Autor:
Dowon An, Gladys J. Keitany, Holly R. Steach, Marion Pepper, Jason M. Schenkel, David Masopust, Akshay T. Krishnamurty, Brian D. Hondowicz, William A. Altemeier, Kathryn A. Fraser, Karen S. Kim, Esteban N. Garza, James J. Moon
Publikováno v:
Immunity. 44(1)
Exposure to inhaled allergens generates T helper 2 (Th2) CD4(+) T cells that contribute to episodes of inflammation associated with asthma. Little is known about allergen-specific Th2 memory cells and their contribution to airway inflammation. We gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7711bb32dd3b0e2593e6fd614e507a72
https://pubmed.ncbi.nlm.nih.gov/26789918
https://pubmed.ncbi.nlm.nih.gov/26789918