Výsledky vyhledávání - "Gladys E. Chiappe"

Mineralocorticoid receptor activation is crucial in the signalling pathway leading to the Anrep effect

Autor: Horacio E. Cingolani, Gladys E. Chiappe de Cingolani, Mariela Nolly, Romina Gisel Díaz, Irene L. Ennis, Néstor G. Pérez, Claudia I. Caldiz

Publikováno v: The Journal of Physiology. 589:6051-6061

The increase in myocardial reactive oxygen species after epidermal growth factor receptor transactivation is a crucial step in the autocrine/paracrine angiotensin II/endothelin receptor activation leading to the slow force response to stretch (SFR).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a147b41df3e84c6ddac393b58b44a759
https://doi.org/10.1113/jphysiol.2011.218750

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Antibodies against the cardiac sodium/bicarbonate co-transporter (NBCe1) as pharmacological tools

Autor: Alejandro Orlowski, Joseph R. Casey, Ernesto A. Aiello, Gladys E. Chiappe de Cingolani, Verónica Celeste De Giusti, Bernardo V. Alvarez, María C. Villa-Abrille

Publikováno v: British Journal of Pharmacology. 164:1976-1989

BACKGROUND AND PURPOSE Na+/HCO3- co-transport (NBC) regulates intracellular pH (pHi) in the heart. We have studied the electrogenic NBC isoform NBCe1 by examining the effect of functional antibodies to this protein. EXPERIMENTAL APPROACH We generated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11015bb2d1fb4388bd146c2f3a090360
https://doi.org/10.1111/j.1476-5381.2011.01496.x

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Decreased Activity of the Na + /H + Exchanger by Phosphodiesterase 5A Inhibition Is Attributed to an Increase in Protein Phosphatase Activity

Autor: Gladys E. Chiappe de Cingolani, Irene L. Ennis, Carolina D. Garciarena, Alejandra M. Yeves, Mariela Nolly, Horacio E. Cingolani

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

The beneficial effect of phosphodiesterase 5A inhibition in ischemia/reperfusion injury and cardiac hypertrophy is well established. Inhibition of the cardiac Na/H exchanger (NHE-1) exerts beneficial effects on these same conditions, and a possible l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee17bb97904099f59116baddb1ce596
https://doi.org/10.1161/hypertensionaha.110.151324

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The Anrep effect requires transactivation of the epidermal growth factor receptor

Autor: María C. Villa-Abrille, Horacio E. Cingolani, Irene L. Ennis, Gladys E. Chiappe de Cingolani, Mariela Nolly, María Jesús Casarini, Néstor G. Pérez, Claudia I. Caldiz

Publikováno v: The Journal of Physiology. 588:1579-1590

Myocardial stretch elicits a biphasic contractile response: the Frank–Starling mechanism followed by the slow force response (SFR) or Anrep effect. In this study we hypothesized that the SFR depends on epidermal growth factor receptor (EGFR) transa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e74ca71c22d6a087a1d5c47541be580a
https://doi.org/10.1113/jphysiol.2009.186619

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Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart

Autor: Gladys E. Chiappe de Cingolani, Enrique Leo Portiansky, Claudia I. Caldiz, Carolina D. Garciarena, Irene L. Ennis

Publikováno v: Journal of Applied Physiology. 106:1325-1331

Na+/H+ exchanger (NHE-1) inhibition was demonstrated to induce the regression of cardiac hypertrophy (CH) in several experimental models and to inhibit mitochondrial death pathway in “in-vitro” experiments. Since recent reports show that NHE-1 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f26b582928a367115f851ced389e7e
https://doi.org/10.1152/japplphysiol.91300.2008

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Na+/H+exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action

Autor: María V. Correa, Guillermo Raúl Schinella, Carolina D. Garciarena, Susana M. Mosca, Claudia I. Caldiz, Irene L. Ennis, Gladys E. Chiappe de Cingolani, Horacio E. Cingolani

Publikováno v: Journal of Applied Physiology. 105:1706-1713

The possibility of a direct mitochondrial action of Na+/H+exchanger-1 (NHE-1) inhibitors decreasing reactive oxygen species (ROS) production was assessed in cat myocardium. Angiotensin II and endothelin-1 induced an NADPH oxidase (NOX)-dependent incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b954a46d3a0300dcca4cd666244814c
https://doi.org/10.1152/japplphysiol.90616.2008

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Is Cardiac Hypertrophy in Spontaneously Hypertensive Rats the Cause or the Consequence of Oxidative Stress?

Autor: Carolina D. Garciarena, Claudia I. Caldiz, Juliana Catalina Fantinelli, María Cecilia Álvarez, Gloria M. Cónsole, Susana M. Mosca, Gladys E. Chiappe de Cingolani

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

The aim of this work was to assess the possible correlation between oxidative damage and the development of cardiac hypertrophy in heart tissue from young (40-d-old) and older (4-, 11- and 19-month-old) spontaneously hypertensive rats (SHR) in compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d93d1bedfab76eb681ecaf9be0063f
https://doi.org/10.1291/hypres.31.1465

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Mitochondrial reactive oxygen species activate the slow force response to stretch in feline myocardium

Autor: Alejandra M. Yeves, Néstor G. Pérez, Claudia I. Caldiz, Leonardo P. Novaretto, Gladys E. Chiappe de Cingolani, Horacio E. Cingolani, Irene L. Ennis, Carolina D. Garciarena, Raul A Dulce

Publikováno v: The Journal of Physiology. 584:895-905

When the length of the myocardium is increased, a biphasic response to stretch occurs involving an initial rapid increase in force followed by a delayed slow increase called the slow force response (SFR). Confirming previous findings involving angiot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49fa4df65d8a84868b72ca7f80e35fa8
https://doi.org/10.1113/jphysiol.2007.141689

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Involvement of the Na+-independent Cl–/HCO3–exchange (AE) isoform in the compensation of myocardial Na+/H+isoform 1 hyperactivity in spontaneously hypertensive rats

Autor: Patricio E. Morgan, Gladys E. Chiappe de Cingolani, Fernando Farias, María C. Camilión de Hurtado

Publikováno v: Canadian Journal of Physiology and Pharmacology. 83:397-404

Enhanced activity of Na+/H+isoform 1 (NHE-1) and the Na+-independent Cl–/HCO3–exchange (AE) is a feature of the hypertrophied myocardium in spontaneously hypertensive rats (SHR). The present study explored the possibility that sustained intracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de60e95e547fb9868b612a70c648ffc4
https://doi.org/10.1139/y05-025

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Influence of Na + -Independent Cl − -HCO 3 − Exchange on the Slow Force Response to Myocardial Stretch

Autor: Joseph R. Casey, Néstor G. Pérez, Raul A Dulce, Gladys E. Chiappe, María C. Camilión de Hurtado, Horacio E. Cingolani, Patricio G. Morgan, Bernardo V. Alvarez, Irene L. Ennis

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Previous work demonstrated that the slow force response (SFR) to stretch is due to the increase in calcium transients (Ca2+T) produced by an autocrine-paracrine mechanism of locally produced angiotensin II/endothelin activating Na+-H+ exchange. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d377bed5bdf63df1f390a75b495e97e
https://doi.org/10.1161/01.res.0000102408.25664.01

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