Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gladstone Thompson"'
Publikováno v:
Biochemistry. 37:7885-7891
p21-activated kinases (PAKs) serve as effector proteins for the GTP-binding proteins Cdc42 and Rac. They are serine/threonine kinases containing the Cdc42/Rac interactive binding (CRIB) motif. The main aim of this study was to define the minimal doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::018d42da550e389ec77485c352790f4c
https://doi.org/10.1021/bi980140+
https://doi.org/10.1021/bi980140+
Publikováno v:
International Journal of Pharmaceutics. 106:85-88
Lipophilic modified peptides corresponding to the COOH terminus of subunit 2 of herpes simplex virus ribonucleotide reductase were synthesised and evaluated. Lipidic conjugation on the N-terminus greatly enhanced the peptide inhibitory activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8215f41937730c214f11698a082a21c0
https://doi.org/10.1016/0378-5173(94)90279-8
https://doi.org/10.1016/0378-5173(94)90279-8
Autor:
Margarete Neu, Donald O. Somers, Gladstone Thompson, Richard Martyn Angell, Kendra E. Hightower, Jeffery L. Smith, Maria Cichy-Knight, Tsu Tshen Chuang, Ruolan Wang, Murray J. B. Brown, Sonia Thomas, Allison K. Dunn, Robyn L. Shea, Susanna Malkakorpi, James R. Musgrave, Francis Louis Atkinson, John A. Christopher, Paul Rowland
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(5)
The identification and exploration of a novel, potent and selective series of N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amide inhibitors of JNK2 and JNK3 kinases is described. Compounds 5a and 11a were identified as potent inhibitors of JNK3 (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca2005b257f5ed43bfb9a7fb771da90
https://pubmed.ncbi.nlm.nih.gov/17194588
https://pubmed.ncbi.nlm.nih.gov/17194588