MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer

Autor: Mattesen, T.B., Rasmussen, M.H., Sandoval, J., Ongen, H., Árnadóttir, S.S., Gladov, J., Martínez Cardús, Anna, Castro de Moura, Manuel, Madsen, A.H., Laurberg, S., Dermitzakis, E.T., Esteller, M., Andersen, C.L., Bramsen, J.B., Universitat Autònoma de Barcelona

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
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Dipòsit Digital de la UB
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Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Mattesen, T B, Rasmussen, M H, Sandoval, J, Ongen, H, Árnadóttir, S S, Gladov, J, Martinez-Cardus, A, Castro de Moura, M, Madsen, A H, Laurberg, S, Dermitzakis, E T, Esteller, M, Andersen, C L & Bramsen, J B 2020, ' MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer ', Nature Communications, vol. 11, 2025 . https://doi.org/10.1038/s41467-020-16000-6
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r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Transcriptional characterization and classification has potential to resolve the inter-tumor heterogeneity of colorectal cancer and improve patient management. Yet, robust transcriptional profiling is difficult using formalin-fixed, paraffin-embedded

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MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer.

Autor: Mattesen TB; Department of Molecular Medicine, Aarhus University Hospital, 8200, Aarhus, Denmark., Rasmussen MH; Department of Molecular Medicine, Aarhus University Hospital, 8200, Aarhus, Denmark., Sandoval J; Epigenomic Unit, Health Research Institute La Fe (ISSLaFe), Valencia, Spain.; Biomarker and precision medicine Unit, Health Research Institute La Fe (ISSLaFe), Valencia, Spain., Ongen H; Genetic Medicine and Development, University of Geneva Medical School-CMU, 1 Rue Michel-Servet, 1211, Geneva, Switzerland., Árnadóttir SS; Department of Molecular Medicine, Aarhus University Hospital, 8200, Aarhus, Denmark., Gladov J; Department of Molecular Medicine, Aarhus University Hospital, 8200, Aarhus, Denmark., Martinez-Cardus A; Badalona Applied Research Group in Oncology (B-ARGO), Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Catalonia, Spain.; Medical Oncology Service, Institute Catalan of Oncology (ICO), Badalona, Barcelona, Catalonia, Spain., Castro de Moura M; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain., Madsen AH; Department of Surgery, Hospitalsenheden Vest, 7400, Herning, Denmark., Laurberg S; Colorectal Surgical Unit, Department of Surgery, Aarhus University Hospital, 8200, Aarhus, Denmark., Dermitzakis ET; Genetic Medicine and Development, University of Geneva Medical School-CMU, 1 Rue Michel-Servet, 1211, Geneva, Switzerland., Esteller M; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, 8200, Aarhus, Denmark. Cla@clin.au.dk., Bramsen JB; Department of Molecular Medicine, Aarhus University Hospital, 8200, Aarhus, Denmark. Bramsen@clin.au.dk.

Publikováno v: Nature communications [Nat Commun] 2020 Apr 24; Vol. 11 (1), pp. 2025. Date of Electronic Publication: 2020 Apr 24.