Výsledky vyhledávání

Akademický článek

Comparing personalized brain-based and genetic risk scores for major depressive disorder in large population samples of adults and adolescents

Autor: Gladi Thng, Xueyi Shen, Aleks Stolicyn, Mathew A. Harris, Mark J. Adams, Miruna C. Barbu, Alex S. F. Kwong, Sophia Frangou, Stephen M. Lawrie, Andrew M. McIntosh, Liana Romaniuk, Heather C. Whalley

Publikováno v: European Psychiatry, Vol 65 (2022)

Abstract Background Major depressive disorder (MDD) is a polygenic disorder associated with brain alterations but until recently, there have been no brain-based metrics to quantify individual-level variation in brain morphology. Here, we evaluated a

Externí odkaz: https://doaj.org/article/50eb08abd1764d5fadc0c0b451a255a7

Zobrazit plný text záznamu

Pathway-based polygenic risk scores for schizophrenia and associations with reported psychotic-like experiences and neuroimaging phenotypes in UK Biobank

Autor: Miruna C. Barbu, Maria Viejo-Romero, Gladi Thng, Mark J. Adams, Katie Marwick, Seth GN Grant, Andrew M. McIntosh, Stephen M. Lawrie, Heather C. Whalley

Publikováno v: Barbu, M C, Viejo-Romero, M, Thng, G, Adams, M J, Marwick, K, Grant, S, Mcintosh, A M, Lawrie, S M & Whalley, H C 2023, ' Pathway-based polygenic risk scores for schizophrenia and associations with reported psychotic-like experiences and neuroimaging phenotypes in UK Biobank ', Biological psychiatry global open science . https://doi.org/10.1016/j.bpsgos.2023.03.004

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443c2e931c256b1e4666f03ecafbb18f
https://hdl.handle.net/20.500.11820/44fea745-e14e-4c78-b77a-fcf347d2725a

Zobrazit plný text záznamu

Classification accuracy of structural and functional connectomes across different depressive phenotypes

Autor: Hon Wah Yeung, Aleks Stolicyn, Xueyi Shen, Mark J. Adams, Liana Romaniuk, Gladi Thng, Colin R. Buchanan, Elliot M. Tucker-Drob, Mark E. Bastin, Andrew M. McIntosh, Simon R. Cox, Keith M. Smith, Heather C. Whalley

Phenotyping of major depressive disorder (MDD) in research can vary from study to study, which, together with heterogeneity of the disorder, may contribute to the inconsistent associations with various risk factors including neuroimaging features. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa5bcc679190999461bd5cea295dd2d0
https://doi.org/10.1101/2022.11.22.22282621

Zobrazit plný text záznamu

Pathway-based polygenic risk scores for schizophrenia and associations with clinical and neuroimaging phenotypes in UK Biobank

Autor: Miruna C. Barbu, Gladi Thng, Mark J. Adams, Katie Marwick, Seth GN Grant, Andrew M. McIntosh, Stephen M. Lawrie, Heather C. Whalley

BackgroundSchizophrenia is a heritable psychiatric disorder with a polygenic architecture. Genome-wide association studies (GWAS) have reported an increasing number of risk-associated variants and polygenic risk scores (PRS) now explain 17% of the va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6967aae8360ae3490a5a9bdc6c2a710
https://doi.org/10.1101/2022.07.12.22277553

Zobrazit plný text záznamu

Salivary cytokine cluster moderates the association between caregivers perceived stress and emotional functioning in youth

Autor: Danielle Hessler, Victoria Keeton, Nancy E. Adler, Michael J. Meaney, Holly Wing, Kieran J. O’Donnell, Carine Parent, Gladi Thng, Patrícia Pelufo Silveira, Michelle Z. L. Kee, Euclides José de Mendonça Filho, Irina Pokhvisneva, Matthew S. Pantell, Laura M. Gottlieb

Publikováno v: Brain, Behavior, and Immunity. 94:125-137

Some individuals exposed to early life stress show evidence of enhanced systemic inflammation and are at greater risk for psychopathology. In the current study, caregivers and their offspring (0–17 years) were recruited at a pediatric clinic visit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d790cc8eabd17161bf018a4bebc6b816
https://doi.org/10.1016/j.bbi.2021.02.025

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání