Výsledky vyhledávání - "Glòria Sanclimens"

Akademický článek

Protein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylation.

Autor: Johanna Scheper, Marta Guerra-Rebollo, Glòria Sanclimens, Alejandra Moure, Isabel Masip, Domingo González-Ruiz, Nuria Rubio, Bernat Crosas, Oscar Meca-Cortés, Noureddine Loukili, Vanessa Plans, Antonio Morreale, Jerónimo Blanco, Angel R Ortiz, Angel Messeguer, Timothy M Thomson

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e11403 (2010)

BACKGROUND: Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent DNA damage tolerance and activation of NF-kappaB by extrinsic signals, are regulated by the tagging of key p

Externí odkaz: https://doaj.org/article/5e9127a24934479b8668f5d2bd51efe2

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Cell-penetrating γ-peptide/antimicrobial undecapeptide conjugates with anticancer activity

Autor: Lidia Feliu, Cristina Rosés, Adriana Blancafort, Teresa Puig, Daniel Carbajo, Miriam Royo, Anna D. Cirac, Glòria Oliveras, Fernando Albericio, Eduard Bardají, Josep Farrera-Sinfreu, Marta Planas, Glòria Sanclimens

Publikováno v: Tetrahedron. 68:4406-4412

In this study, we combined a cell-penetrating γ-peptide, PEG-1, with antimicrobial undecapeptides in order to provide compounds with anticancer properties against MDA-MB-231 human breast cancer cells. We demonstrated that the conjugates were more cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f645026eec69f79643a39c3e852fcde3
https://doi.org/10.1016/j.tet.2012.02.003

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Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters

Autor: Laura Mondragón, Isabel Marzo, Glòria Sanclimens, Mar Orzáez, María J. Vicent, Angel Messeguer, Enrique Pérez-Payá

Publikováno v: Peptides. 28:958-968

We have identified a family of peptoids that inhibits in vitro the activity of the apoptosome, a macromolecular complex that activates mitochondrial-dependent apoptosis pathways. The analysis of peptide-based cell compatible delivery systems of the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b45e0d2d4b07ce0f3519f28df25f5df
https://doi.org/10.1016/j.peptides.2007.02.014

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Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis

Autor: Antonio Ferrer-Montiel, María J. Vicent, Ismael Mingarro, Isabel Masip, Angel G. Martin, Enrique Pérez-Payá, Howard O. Fearnhead, Angel Messeguer, Glòria Sanclimens, Gema Malet, Mar Orzáez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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10 pages, 5 figures.-- PMID: 16341125 [PubMed].-- Available online Dec 9, 2005.
Supporting information available at: http://www.nature.com/cdd/journal/v13/n9/suppinfo/4401828s1.html?url=/cdd/journal/v13/n9/abs/4401828a.html
Apoptosis is a b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7206c5675eba9e7c4f1e3ed2a13da471
https://doi.org/10.1038/sj.cdd.4401828

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Preparation of de Novo Globular Proteins Based on Proline Dendrimers

Autor: Miriam Royo, Fernando Albericio, Laia Crespo, Ernest Giralt, Glòria Sanclimens

Publikováno v: The Journal of Organic Chemistry. 70:6274-6281

A synthetic method for the preparation of protein-like globular dendrimers derived from a combination of proline, glycine and imidazolidin ring as branching unit is described. The methodology allows the synthesis of novel peptide dendrimers up to fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f511036618313d9e732f13db88987f0
https://doi.org/10.1021/jo050720u

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Saturated resins or stress of the resin

Autor: Ernest Giralt, Fernando Albericio, Laia Crespo, Miquel Pons, Miriam Royo, Glòria Sanclimens

Publikováno v: Tetrahedron Letters. 44:1751-1754

Although the solid-phase mode is an excellent strategy for the preparation of both biomolecules and small molecules, the synthesis of polyproline-based dendrimers has provided evidence that the capacity of the bead is limited. This phenomenon, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2855df06d042749073faedbdc45c4938
https://doi.org/10.1016/s0040-4039(03)00109-6

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Protein-Protein Interaction Antagonists as Novel Inhibitors of Non-Canonical Polyubiquitylation

Autor: Alejandra Moure, Noureddine Loukili, Isabel Masip, Timothy M. Thomson, Johanna Scheper, Nuria Rubio, Vanessa Plans, Angel R. Ortiz, Angel Messeguer, Domingo González-Ruiz, Bernat Crosas, Óscar Meca-Cortés, Jerónimo Blanco, Antonio Morreale, Marta Guerra-Rebollo, Glòria Sanclimens

Publikováno v: PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
PLoS ONE, Vol 5, Iss 6, p e11403 (2010)
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE

[Background]: Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent DNA damage tolerance and activation of NF-kB by extrinsic signals, are regulated by the tagging of key pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2fed64f48af5afedd7e2ce4386b6ea
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12691

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Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors

Autor: Laura Mondragón, Enrique Pérez-Payá, Glòria Sanclimens, Mar Orzáez, Ana Armiñán, Alejandra Moure, Angel Messeguer, María J. Vicent, Pilar Sepúlveda

Publikováno v: JOURNAL OF MEDICINAL CHEMISTRY
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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The programmed cell death or apoptosis plays both physiological and pathological roles in biology. Anomalous activation of apoptosis has been associated with malignancies. The intrinsic mitochondrial pathway of apoptosis activation occurs through a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21e7ea7459bad677e4bf5100d453c3e
https://pubmed.ncbi.nlm.nih.gov/18197610

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Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters: effective methods to improve inhibition of mitochondria-mediated apoptosis

Autor: Mar, Orzáez, Laura, Mondragón, Isabel, Marzo, Glòria, Sanclimens, Angel, Messeguer, Enrique, Pérez-Payá, María J, Vicent

Publikováno v: Peptides. 28(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efdc10f4432350ac918312859e0795db
https://pubmed.ncbi.nlm.nih.gov/17408805

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Peptide and Amide Bond Containing Dendrimers

Autor: Laia Crespo, Fernando Albericio, Ernest Giralt, Miquel Pons, Miriam Royo, Glòria Sanclimens

Publikováno v: ChemInform. 36

1.3. Applications of Peptide Dendrimers 1665 1.3.1. Why Peptides? 1665 1.3.2. Applications 1666 2. Synthesis 1666 2.1. Peptide Synthesis 1666 2.1.1. In Solution 1666 2.1.2. On Solid-Phase 1667 2.1.3. Solid-Phase/Solution Hybrid 1667 2.2. Dendrimer Sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::781bec583d5e20dc75b34a0132ba2b1d
https://doi.org/10.1002/chin.200536230

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