Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gjalt G. Wybenga"'
Autor:
Gjalt G. Wybenga, Wei-Shen Wu
To combat bacterial resistance against antibiotics, glycosyltransferase inhibiting molecules, which block the synthesis of the pre-cursor of the bacterial cell wall, need to be discovered and developed. In this study, we demonstrate that phenylphenox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5d1b8537830d354ac3f71ec2b6ddbd
Autor:
Bauke W. Dijkstra, Bian Wu, Wiktor Szymanski, Ben L. Feringa, Gjalt G. Wybenga, Dick B. Janssen
Publikováno v:
Biochemistry, 53(19), 3187-3198. AMER CHEMICAL SOC
Phenylalanine-2,3-aminomutase (PAM) from Taxus chinensis, a 4-methylidene-imidazole-5-one (MIO)-dependent enzyme, catalyzes the reversible conversion of (S)-alpha-phenylalanine into (R)-beta-phenylalanine via trans-cinnamic acid. The enzyme also cata
Autor:
Gjalt G. Wybenga, Dick B. Janssen, Maaike Jansen, Bauke W. Dijkstra, Bian Wu, Sebastian Bartsch, Matthew M. Heberling
Publikováno v:
ChemCatChem, 5(7), 1797-1802. WILEY-V C H VERLAG GMBH
ChemCatChem
ChemCatChem
An aminomutase, naturally catalyzing the interconversion of (S)--phenylalanine and (R)--phenylalanine, was converted into an ammonia lyase catalyzing the nonoxidative deamination of phenylalanine to cinnamic acid by a rational single-point mutation.
Autor:
Ciprian G. Crismaru, Gjalt G. Wybenga, Stefaan Marie André De Wildeman, Ben L. Feringa, Hein J. Wijma, Gerrit J. Poelarends, Dick B. Janssen, Bauke W. Dijkstra, Wiktor Szymanski, Bian Wu, Sebastian Bartsch
Publikováno v:
Applied and Environmental Microbiology
Applied and environmental microbiology, 79(1), 185-195. AMER SOC MICROBIOLOGY
Applied and environmental microbiology, 79(1), 185-195. AMER SOC MICROBIOLOGY
By selective enrichment, we isolated a bacterium that can use β-phenylalanine as a sole nitrogen source. It was identified by 16S rRNA gene sequencing as a strain of Variovorax paradoxus . Enzyme assays revealed an aminotransferase activity. Partial
Autor:
Chris Williams, Gjalt G. Wybenga, Peter A. Jekel, Thomas R. M. Barends, Bauke W. Dijkstra, Jolanda J. Polderman-Tijmes, Dick B. Janssen
Publikováno v:
Journal of Biological Chemistry. 281:5804-5810
The alpha-amino acid ester hydrolase (AEH) from Acetobacter turbidans is a bacterial enzyme catalyzing the hydrolysis and synthesis of beta-lactam antibiotics. The crystal structures of the native enzyme, both unliganded and in complex with the hydro
Autor:
Dick B. Janssen, Marcelo F. Masman, Sebastian Bartsch, Bauke W. Dijkstra, Siewert J. Marrink, Matthew M. Heberling, Gjalt G. Wybenga
Publikováno v:
ACS chemical biology, 10(4), 989-997. AMER CHEMICAL SOC
Deciphering the structural features that functionally separate ammonia lyases from aminomutases is of interest because it may allow for the engineering of more efficient aminomutases for the synthesis of unnatural amino acids (e.g., beta-amino acids)
Publikováno v:
The Journal of Biological Chemistry, 287(34), 28495-28502. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Chiral beta-amino acids occur as constituents of various natural and synthetic compounds with potentially useful bioactivities. The pyridoxal 5'-phosphate (PLP)-dependent S-selective transaminase from Mesorhizobium sp. strain LUK (MesAT) is a fold ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6602987b05b859a934e955b4c327d8
https://research.rug.nl/en/publications/746cbe86-5305-4ffa-8993-8f36afdc55a9
https://research.rug.nl/en/publications/746cbe86-5305-4ffa-8993-8f36afdc55a9
Autor:
Bian Wu, Dick B. Janssen, Ben L. Feringa, Gjalt G. Wybenga, Gerrit J. Poelarends, Sebastian Bartsch, Matthew M. Heberling, Bauke W. Dijkstra, Wiktor Szymanski, Stefaan Marie André De Wildeman
Publikováno v:
Angewandte Chemie-International Edition, 51(2), 482-486. WILEY-V C H VERLAG GMBH
Turn to switch: A mutant of phenylalanine aminomutase was engineered that can catalyze the regioselective amination of cinnamate derivatives (see scheme, red) to, for example, β-amino acids. This regioselectivity, along with the X-ray crystal struct
Autor:
Barends TR; Laboratories of Biophysical Chemistry and Biochemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands., Polderman-Tijmes JJ, Jekel PA, Williams C, Wybenga G, Janssen DB, Dijkstra BW
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2006 Mar 03; Vol. 281 (9), pp. 5804-10. Date of Electronic Publication: 2005 Dec 23.