Zobrazeno 1 - 10
of 345
pro vyhledávání: '"Gj. Dockray"'
Publikováno v:
Experimental Physiology. 81:151-154
Endocrine cells of the pyloric antral mucosa are known to take up gamma-amino-n-butyric acid (GABA), but the functional significance of this is uncertain. We now report that specific uptake of [3H]GABA by rat antral, but not corpus, mucosa is enhance
Autor:
GJ Dockray
Publikováno v:
Lancet (London, England). 358(9284)
Autor:
ER Forster, GJ Dockray
Publikováno v:
Experimental physiology. 77(5)
It is clear that the intestinal hormone cholecystokinin (CCK) inhibits gastric emptying, but doubts remain about the physiological significance of this action. Evaluation of the apparently conflicting data is complicated by the fact that little is kn
Autor:
GJ Dockray, ER Forster
Publikováno v:
Experimental physiology. 76(4)
The presence of circulating antibodies to calcitonin gene-related peptide (CGRP) enhanced the damaging effect of ethanol on the rat gastric mucosa. Taken together with previous experimental and morphological data the results suggest that CGRP release
Publikováno v:
Gastroenterology. 114:A889
Publikováno v:
Gastroenterology. 92:1220-1225
The metabolism of synthetic human sulfated heptadecapeptide gastrin (G-17) was studied in normal human volunteers. Plasma concentrations were measured by radioimmunoassay using antibodies specific for intact G-17, and for the C- and Nterminus of G-17
Publikováno v:
FEBS Letters. 210:185-188
Antibodies to the extreme C-terminal region of human progastrin have been used to monitor the isolation of high-Mr immunoreactive material in a gastrinoma extract. Microsequence analysis of the product revealed amino acid residues in the first 18 pos
Autor:
GJ Dockray, CR Hopkins
Publikováno v:
The Journal of Cell Biology
Since gastrin and its related peptides are secreted by a minority population of widely dispersed cells in mamamalian tissues it has, in the past, been difficult to study the subcellular aspects of their secretion. From published reports (1, 2) it see
Publikováno v:
FEBS Letters. 204:386-390
The C-terminal flanking peptide of preprocholecystokinin has been isolated from rat brain. Micro-sequence analysis revealed the primary structure: Ser-Ala-Glu-Asp-Tyr-Glu-Tyr-Pro-Ser. Arylsulphatase and mild acid hydrolysis suggested that both tyrosi
Publikováno v:
Journal of Clinical Investigation. 77:376-381
Recent studies on the gene sequence encoding the human pyloric antral hormone, gastrin, indicate a precursor of 101 residues. We have now raised antibodies to a synthetic analogue corresponding to (Tyr)-human progastrin COOH-terminal pentapeptide. Th