Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity

Autor: Gj, Grover, Alonzo Aj, D., Keith Garlid, Bajgar R, Nj, Lodge, Pg, Sleph, Rb, Darbenzio, Ta, Hess, Ma, Smith, Paucek P, Ks, Atwal

Publikováno v: Europe PubMed Central

Previous work described ATP-sensitive K(+) channel (K(ATP)) openers (e.g., BMS-180448), which retain the cardioprotective activity of agents such as cromakalim while being significantly less potent as vasodilators. In this study, we describe the phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::28d1728cd9b141566b2813444eaa1c4c
https://pubmed.ncbi.nlm.nih.gov/11356945

Combining sitagliptin/metformin with a functional fiber delays diabetes progression in Zucker rats.

Autor: Reimer RA; Faculty of Kinesiology Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, Canada T2N 1N4 Product Safety Labs, Department of Pharmacology, Dayton, New Jersey, USA Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA Factors Group of Nutritional Companies, Inc. R&D, 3655 Bonneville Place, Burnaby, British Columbia, Canada Canadian Centre for Functional Medicine, 1552 United Boulevard, Coquitlam, British Columbia, Canada University of British Columbia, Food, Nutrition and Health Program, Vancouver, British Columbia, Canada., Grover GJ, Koetzner L, Gahler RJ, Lyon MR, Wood S

Publikováno v: The Journal of endocrinology [J Endocrinol] 2014 Feb 10; Vol. 220 (3), pp. 361-73. Date of Electronic Publication: 2014 Feb 10 (Print Publication: 2014).

Sitagliptin reduces hyperglycemia and increases satiety hormone secretion more effectively when used with a novel polysaccharide in obese Zucker rats.

Autor: Reimer RA; Faculty of Kinesiology, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada. reimer@ucalgary.ca, Grover GJ, Koetzner L, Gahler RJ, Juneja P, Lyon MR, Wood S

Publikováno v: The Journal of nutrition [J Nutr] 2012 Oct; Vol. 142 (10), pp. 1812-20. Date of Electronic Publication: 2012 Aug 22.

Effects of the Soluble Fiber Complex PolyGlycopleX on Glucose Homeostasis and Body Weight in Young Zucker Diabetic Rats.

Autor: Grover GJ; Department of Pharmacology, Eurofins-Product Safety Laboratories Dayton, NJ, USA., Koetzner L, Wicks J, Gahler RJ, Lyon MR, Reimer RA, Wood S

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2011 Sep 07; Vol. 2, pp. 47. Date of Electronic Publication: 2011 Sep 07 (Print Publication: 2011).

The soluble fiber complex PolyGlycopleX lowers serum triglycerides and reduces hepatic steatosis in high-sucrose-fed rats.

Autor: Reimer RA; Faculty of Kinesiology and Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 1N4. reimer@ucalgary.ca, Grover GJ, Koetzner L, Gahler RJ, Lyon MR, Wood S

Publikováno v: Nutrition research (New York, N.Y.) [Nutr Res] 2011 Apr; Vol. 31 (4), pp. 296-301.