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Akademický článek

Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53

Autor: Rafaela Muniz de Queiroz, Gizem Efe, Asja Guzman, Naoko Hashimoto, Yusuke Kawashima, Tomoaki Tanaka, Anil K. Rustgi, Carol Prives

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Although the E3 ligase Mdm2 and its homologue and binding partner MdmX are the major regulators of the p53 tumor suppressor protein, it is now evident that Mdm2 and MdmX have multiple functions that do not involve p53. As one example, it is

Externí odkaz: https://doaj.org/article/6c7075f8b8934d2fa532d7c44cb97399

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Akademický článek

Tumor niche network-defined subtypes predict immunotherapy response of esophageal squamous cell cancer

Autor: Kyung-Pil Ko, Shengzhe Zhang, Yuanjian Huang, Bongjun Kim, Gengyi Zou, Sohee Jun, Jie Zhang, Yahui Zhao, Cecilia Martin, Karen J. Dunbar, Gizem Efe, Anil K. Rustgi, Hiroshi Nakagawa, Haiyang Zhang, Zhihua Liu, Jae-Il Park

Publikováno v: iScience, Vol 27, Iss 5, Pp 109795- (2024)

Summary: Despite the promising outcomes of immune checkpoint inhibitors (ICIs), resistance to ICI presents a new challenge. Therefore, selecting patients for specific ICI applications is crucial for maximizing therapeutic efficacy. Herein, we curated

Externí odkaz: https://doaj.org/article/b0c57a6133c14aa2a1408bad70cd2bfc

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Akademický článek

Overcoming Barriers of Age to Enhance Efficacy of Cancer Immunotherapy: The Clout of the Extracellular Matrix

Autor: Mark Owyong, Gizem Efe, Michael Owyong, Aamna J. Abbasi, Vaishnavi Sitarama, Vicki Plaks

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 6 (2018)

There is a growing list of cancer immunotherapeutics approved for use in a population with an increasing number of aged individuals. Cancer immunotherapy (CIT) mediates tumor destruction by activating anti-tumor immune responses that have been silenc

Externí odkaz: https://doaj.org/article/41f1e7efe7ae413e945663cc0636478f

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Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma

Autor: Karen J. Dunbar, Tatiana A. Karakasheva, Qiaosi Tang, Gizem Efe, Eric W. Lin, Michael Harris, Varun Sahu, Uma M. Sachdeva, Jianhua Hu, Andres J. Klein-Szanto, Brian Henick, J. Alan Diehl, Hiroshi Nakagawa, Anil K. Rustgi

Publikováno v: Molecular Cancer Research. :OF1-OF12

Cancer-associated fibroblasts (CAF) can promote tumor growth, metastasis, and therapeutic resistance in esophageal squamous cell carcinoma (ESCC), but the mechanisms of action remain elusive. Our objective was to identify secreted factor(s) that medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d797a0ee7e68f1d658b45f17b45a616e
https://doi.org/10.1158/1541-7786.mcr-22-0872

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Sprouty4 is required for Mdm2 regulation of invasion, focal adhesion formation and metastasis in cells lacking p53

Autor: Rafaela Muniz de Queiroz, Gizem Efe, Asja Guzman, Naoko Hashimoto, Yusuke Kawashima, Tomoaki Tanaka, Anil K Rustgi, Carol Prives

SummaryAlthough the E3 ligase Mdm2 and its homologue and binding partner MdmX are the major regulators of the p53 tumor suppressor protein, it is now evident that Mdm2 and MdmX have multiple functions that are independent of p53. For example, Mdm2 ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6738147ec9bd60f7d85d4bcaac2e9162
https://doi.org/10.1101/2023.05.08.539890

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