KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress

Autor: Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I. Katz, Gwen A. Lomberk, Raul A. Urrutia, Jonathan P. Katz

Publikováno v: Cell Death and Disease, Vol 14, Iss 5, Pp 1-10 (2023)

Abstract In response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. Yet the mechanisms of these cell fate decisions remain largely unknown, particularly in normal cells. H

Externí odkaz: https://doaj.org/article/ec7f0cfa3b1b4e0b99fa62ec85368f3d

Meiotic Cells Counteract Programmed Retrotransposon Activation via RNA-Binding Translational Repressor Assemblies

Autor: Raphaelle Laureau, Hannah Adeoye, Annie Dyatel, Gizem Dursuk, Matteo De Chiara, Gianni Liti, Anthony Harris, Jia-Xing Yue, Ian R. Adams, Luke E. Berchowitz, Samantha Brown, Elçin Ünal

Publikováno v: Laureau, R, Dyatel, A, Dursuk, G, Brown, S, Adeoye, H, Yue, J-X, De Chiara, M, Harris, A, Ünal, E, Liti, G, Adams, I R & Berchowitz, L E 2021, ' Meiotic Cells Counteract Programmed Retrotransposon Activation via RNA-Binding Translational Repressor Assemblies ', Developmental Cell . https://doi.org/10.1016/j.devcel.2020.11.008
Developmental Cell
Developmental Cell, Elsevier, 2021, 56, pp.22-35.e7. ⟨10.1016/j.devcel.2020.11.008⟩
Developmental Cell, 2021, 56, pp.22-35.e7. ⟨10.1016/j.devcel.2020.11.008⟩
Dev Cell

While retrotransposons must activate in developing gametes in order to survive and propagate, how a retrotransposon selectively activates in the context of meiosis is unclear. These mobile genetic elements can promote evolutionary innovations, but th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbf662c749ee165df7bc7f428eb8da9
https://hdl.handle.net/20.500.11820/ca54900b-c21c-4f4a-b57e-43673320b4c6