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Publikováno v:
Pharmacogenomics. 17:2081-2096
Transcriptome profiling enables discovery of gene networks that are altered in alcoholic brains. This technique has revealed involvement of the brain’s neuroimmune system in regulating alcohol abuse and dependence, and has provided potential therap
Autor:
Gizelle Robinson, Yuri A. Blednov, R. Adron Harris, Dana Most, Jody Mayfield, Laura B. Ferguson
Publikováno v:
International review of neurobiology. 118
Immune or brain proinflammatory signaling has been linked to some of the behavioral effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent models, and ethanol intake activates the immune system in multiple models.