PROX1 transcription factor controls rhabdomyosarcoma growth, stemness, myogenic properties and therapeutic targets.

Autor: Gizaw NY; Stem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Kallio P; Translational Cancer Medicine Program and iCAN Digital Precision Cancer Medicine Flagship, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Punger T; Stem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Gucciardo E; Individualized Drug Therapy Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki 00290, Finland., Haglund C; Translational Cancer Medicine Program and iCAN Digital Precision Cancer Medicine Flagship, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland.; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland., Böhling T; Department of Pathology, University of Helsinki, Helsinki 00014, Finland., Lehti K; Individualized Drug Therapy Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki 00290, Finland.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Solna 17165, Sweden.; Department of Biomedical Laboratory Science, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway., Sampo M; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland., Alitalo K; Translational Cancer Medicine Program and iCAN Digital Precision Cancer Medicine Flagship, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Wihuri Research Institute, Helsinki 00290, Finland., Kivelä R; Stem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Wihuri Research Institute, Helsinki 00290, Finland.; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä 40700, Finland.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 06; Vol. 119 (49), pp. e2116220119. Date of Electronic Publication: 2022 Dec 02.