Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes

Autor: Garay, Bayardo I., Givens, Sophie, Abreu, Phablo, Liu, Man, Yücel, Doğacan, Baik, June, Stanis, Noah, Rothermel, Taylor M., Magli, Alessandro, Abrahante, Juan E., Goloviznina, Natalya A., Soliman, Hossam A.N., Dhoke, Neha R., Kyba, Michael, Alford, Patrick W., Dudley, Samuel C., Jr., van Berlo, Jop H., Ogle, Brenda, Perlingeiro, Rita R.C.

Publikováno v: In Stem Cell Reports 13 September 2022 17(9):2005-2022

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Lysosomal Ca ²⁺ flux modulates automaticity in ventricular cardiomyocytes and correlates with arrhythmic risk.

Autor: Xie A; Department of Medicine, University of Minnesota, 401 East River Parkway, VCRC 1st Floor, Suite 131, Minneapolis, MN 55455, USA.; Lillehei Heart Institute, University of Minnesota, 2231 6th Street SE, Suite 4-156, Minneapolis, MN 55455, USA., Kang GJ; Department of Medicine, University of Minnesota, 401 East River Parkway, VCRC 1st Floor, Suite 131, Minneapolis, MN 55455, USA.; Lillehei Heart Institute, University of Minnesota, 2231 6th Street SE, Suite 4-156, Minneapolis, MN 55455, USA., Kim EJ; Department of Medicine, University of Minnesota, 401 East River Parkway, VCRC 1st Floor, Suite 131, Minneapolis, MN 55455, USA.; Lillehei Heart Institute, University of Minnesota, 2231 6th Street SE, Suite 4-156, Minneapolis, MN 55455, USA., Feng F; Department of Medicine, University of Minnesota, 401 East River Parkway, VCRC 1st Floor, Suite 131, Minneapolis, MN 55455, USA.; Lillehei Heart Institute, University of Minnesota, 2231 6th Street SE, Suite 4-156, Minneapolis, MN 55455, USA., Givens SE; Department of Biomedical Engineering, Stem Cell Institute, University of Minnesota, McGuire Translational Research Facility, 2001 6th Street SE, Mail Code 2873, Minneapolis, MN 55455, USA., Ogle BM; Lillehei Heart Institute, University of Minnesota, 2231 6th Street SE, Suite 4-156, Minneapolis, MN 55455, USA.; Department of Biomedical Engineering, Stem Cell Institute, University of Minnesota, McGuire Translational Research Facility, 2001 6th Street SE, Mail Code 2873, Minneapolis, MN 55455, USA.; Department of Pediatrics, Institute for Engineering in Medicine, University of Minnesota, 420 Delaware Street Southeast, 725 Mayo Memorial Building, MMC 94, Minneapolis, MN 55455, USA., Dudley SC Jr; Department of Medicine, University of Minnesota, 401 East River Parkway, VCRC 1st Floor, Suite 131, Minneapolis, MN 55455, USA.; Lillehei Heart Institute, University of Minnesota, 2231 6th Street SE, Suite 4-156, Minneapolis, MN 55455, USA.

Publikováno v: PNAS nexus [PNAS Nexus] 2023 May 25; Vol. 2 (6), pp. pgad174. Date of Electronic Publication: 2023 May 25 (Print Publication: 2023).