Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Giusy Tornillo"'
Autor:
Giusy Tornillo, Lauren Warrington, Howard Kendrick, Adam T. Higgins, Trevor Hay, Sam Beck, Matthew J. Smalley
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/48df8545687f444d83f560c04bbf5e5a
Publikováno v:
Cancers, Vol 15, Iss 17, p 4324 (2023)
A better understanding of the mechanisms generating tumour heterogeneity will allow better targeting of current therapies, identify potential resistance mechanisms and highlight new approaches for therapy. We have previously shown that in genetically
Externí odkaz:
https://doaj.org/article/7c1ecbe8470f4b69934400efcdec93f6
CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis
Autor:
Huw J. Morgan, Elise Rees, Simone Lanfredini, Kate A. Powell, Jasmine Gore, Alex Gibbs, Charlotte Lovatt, Gemma E. Davies, Carlotta Olivero, Boris Y. Shorning, Giusy Tornillo, Alex Tonks, Richard Darley, Eddie C.Y. Wang, Girish K. Patel
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
The basis of immune evasion, a hallmark of cancer, can differ even when cancers arise from one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell carcinoma. Here we showed that the basal cell carcinoma tumor–initia
Externí odkaz:
https://doaj.org/article/ea703a273eba40cda8c0b9d20462893e
Autor:
Daniel Routledge, Sally Rogers, Yosuke Ono, Lucy Brunt, Valerie Meniel, Giusy Tornillo, Hassan Ashktorab, Toby J Phesse, Steffen Scholpp
Publikováno v:
eLife, Vol 11 (2022)
The Wnt/β-catenin signalling pathway regulates multiple cellular processes during development and many diseases, including cell proliferation, migration, and differentiation. Despite their hydrophobic nature, Wnt proteins exert their function over l
Externí odkaz:
https://doaj.org/article/a5e428de4a624a5780d78e6bd17f40ff
Publikováno v:
Global Challenges, Vol 5, Iss 7, Pp n/a-n/a (2021)
Abstract Anticancer drug development is a crucial step toward cancer treatment, that requires realistic predictions of malignant tissue development and sophisticated drug delivery. Tumors often acquire drug resistance and drug efficacy, hence cannot
Externí odkaz:
https://doaj.org/article/8464978f585545f0948a0f92c4bbc621
Autor:
Liliana D. Ordonez, Lorenzo Melchor, Kirsty R. Greenow, Howard Kendrick, Giusy Tornillo, James Bradford, Peter Giles, Matthew J. Smalley
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 5 (2021)
Understanding the mechanisms underlying tumour heterogeneity is key to the development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour suppressor genes B
Externí odkaz:
https://doaj.org/article/373e2c15d39b4e32aea52cbb5bd3026f
Autor:
Juan Bautista Menendez-Gonzalez, Milica Vukovic, Ali Abdelfattah, Lubaid Saleh, Alhomidi Almotiri, Leigh-anne Thomas, Aloña Agirre-Lizaso, Aleksandra Azevedo, Ana Catarina Menezes, Giusy Tornillo, Sarah Edkins, Kay Kong, Peter Giles, Fernando Anjos-Afonso, Alex Tonks, Ashleigh S. Boyd, Kamil R. Kranc, Neil P. Rodrigues
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 291-306 (2019)
Summary: Subversion of transcription factor (TF) activity in hematopoietic stem/progenitor cells (HSPCs) leads to the development of therapy-resistant leukemic stem cells (LSCs) that drive fulminant acute myeloid leukemia (AML). Using a conditional m
Externí odkaz:
https://doaj.org/article/8fa51b867c2d478fb185ad8f114dbac4
Autor:
Jessica Castro, Giusy Tornillo, Gerardo Ceada, Beatriz Ramos-Neble, Marlon Bravo, Marc Ribó, Maria Vilanova, Matthew J. Smalley, Antoni Benito
Publikováno v:
Cancers, Vol 13, Iss 17, p 4350 (2021)
Despite the significant advances in cancer research made in recent years, this disease remains one of the leading causes of death worldwide. In part, this is due to the fact that after therapy, a subpopulation of self-renewing tumor cells can survive
Externí odkaz:
https://doaj.org/article/9e42b97c271442f3af34a807ca8eceb2
Autor:
Giusy Tornillo, Catherine Knowlson, Howard Kendrick, Joe Cooke, Hasan Mirza, Iskander Aurrekoetxea-Rodríguez, Maria d.M. Vivanco, Niamh E. Buckley, Anita Grigoriadis, Matthew J. Smalley
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3674-3692.e10 (2018)
Summary: The SRC-family kinase LYN is highly expressed in triple-negative/basal-like breast cancer (TNBC) and in the cell of origin of these tumors, c-KIT-positive luminal progenitors. Here, we demonstrate LYN is a downstream effector of c-KIT in nor
Externí odkaz:
https://doaj.org/article/ae35eb1c12854be7852afcc692e44cd2
Autor:
Giusy Tornillo, Sara Cabodi
Publikováno v:
Bio-Protocol, Vol 4, Iss 7 (2014)
The mammary epithelium consists of multiple phenotypically and functionally distinct cell populations, which are organized as a hierarchy of stem cells, progenitors and terminally differentiated cells. Identification of the mechanisms regulating the
Externí odkaz:
https://doaj.org/article/024cba71cc6845d0bb7b92102e952eff