The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance

Autor: Paola Sanese, Katia De Marco, Martina Lepore Signorile, Francesca La Rocca, Giovanna Forte, Marialaura Latrofa, Candida Fasano, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Giusy Bianco, Vito Spilotro, Claudia Ferroni, Matilde Tubertini, Nicoletta Labarile, Lucia De Marinis, Raffaele Armentano, Gianluigi Gigante, Valerio Lantone, Giuliano Lantone, Marina Naldi, Manuela Bartolini, Greta Varchi, Alberto Del Rio, Valentina Grossi, Cristiano Simone

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)

Abstract Background SMYD3 has been found implicated in cancer progression. Its overexpression correlates with cancer growth and invasion, especially in gastrointestinal tumors. SMYD3 transactivates multiple oncogenic mechanisms, favoring cancer devel

Externí odkaz: https://doaj.org/article/8a2633f1acb94d078dc7358f99a7585f

The Increase of miR-195-5p Reduces Intestinal Permeability in Ulcerative Colitis, Modulating Tight Junctions’ Expression

Autor: Viviana Scalavino, Emanuele Piccinno, Giusy Bianco, Nicolò Schena, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 10, p 5840 (2022)

Defects in the intestinal epithelial barrier functions characterize inflammatory conditions such as Inflammatory Bowel Disease (IBD). Overexpression of pro-inflammatory cytokines such as TNF-α, IL-1B, IL-6 and INF-γ trigger epithelial damage. These

Externí odkaz: https://doaj.org/article/323aeabaf78b4b6992b87677c516f523

Magnetic implants in vivo guiding sorafenib liver delivery by superparamagnetic solid lipid nanoparticles

Autor: Maria Lucia Curri, Angela Lopedota, Amalia Azzariti, Giusy Bianco, Ilaria Arduino, Gianluigi Giannelli, Valentino Laquintana, Fabio Canepa, Maria Principia Scavo, Nicoletta Depalo, Antonio Lopalco, Annalisa Cutrignelli, Byung Chul Lee, Massimo Franco, Nunzio Denora, Elisabetta Fanizza, Maria Notarnicola, Rosa Maria Iacobazzi, Fabio Vischio

Publikováno v: Journal of Colloid and Interface Science. 608:239-254

Hypothesis Solid lipid nanoparticles (SLNs), co-encapsulating superparamagnetic iron oxide nanoparticles and sorafenib, have been exploited for magnetic-guided drug delivery to the liver. Two different magnetic configurations, both comprising two sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d134ff81d76ab8ba29b0ee2629ab2f
https://doi.org/10.1016/j.jcis.2021.09.174

Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells

Autor: Angelo Santino, Elisabetta Cavalcanti, Marcello Chieppa, Giusy Bianco, Pietro Campiglia, Veronica Di Sarno, Marina Liso, Giulio Verna

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8349, p 8349 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15
International journal of molecular sciences
22 (2021). doi:10.3390/ijms22158349
info:cnr-pdr/source/autori:Verna G.; Liso M.; Cavalcanti E.; Bianco G.; Di Sarno V.; Santino A.; Campiglia P.; Chieppa M./titolo:Quercetin administration suppresses the cytokine storm in myeloid and plasmacytoid dendritic cells/doi:10.3390%2Fijms22158349/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22

Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5103acfdc15d5b3e19a266b1913f44
https://www.mdpi.com/1422-0067/22/15/8349

Lovastatin, but not orlistat, reduces intestinal polyp volume in an ApcMin/+ mouse model

Autor: Maria Notarnicola, Valeria Tutino, Maria Principia Scavo, Antonio Francavilla, Giusy Bianco, Lorenzo Polimeno, Mario Minoia, Anna Napoli, Maria Gabriella Caruso, Michele Barone, Angela Tafaro

Publikováno v: Oncology Reports. 36:893-899

The statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR) and orlistat, an inhibitor of fatty acid synthase (FAS), inhibit tumor cell growth by restricting cholesterol and fatty acid synthesis, respectively. We previously d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d657cc697ff8b1289d2929140e74af8
https://doi.org/10.3892/or.2016.4856