Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Giuseppina Stifano"'
Autor:
Ricardo Grieshaber-Bouyer, Felix A. Radtke, Pierre Cunin, Giuseppina Stifano, Anaïs Levescot, Brinda Vijaykumar, Nathan Nelson-Maney, Rachel B. Blaustein, Paul A. Monach, Peter A. Nigrovic, ImmGen Consortium
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are aff
Externí odkaz:
https://doaj.org/article/a869daba818542d3a779eb3e37bafc52
Autor:
Giuseppina Stifano, Raffaele De Palma
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/96b10e1b8c80405cb684613fc922224e
Autor:
Sokratis A. Apostolidis, Giuseppina Stifano, Tracy Tabib, Lisa M. Rice, Christina M. Morse, Bashar Kahaleh, Robert Lafyatis
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Objective: The mechanisms that lead to endothelial cell (EC) injury and propagate the vasculopathy in Systemic Sclerosis (SSc) are not well understood. Using single cell RNA sequencing (scRNA-seq), our goal was to identify EC markers and signature pa
Externí odkaz:
https://doaj.org/article/cae8b99b309c494c887a574f013ca6ee
Publikováno v:
Case Reports in Medicine, Vol 2015 (2015)
Macrophage activation syndrome (MAS) is a potentially fatal condition. It belongs to the hemophagocytic lymphohistiocytosis group of diseases. In adults, MAS is rarely associated with systemic lupus erythematosus, but it also arises as complication o
Externí odkaz:
https://doaj.org/article/79c34bd25706452cbdf1b6a0242432ee
Autor:
Felix A Radtke, Peter A. Nigrovic, Nathan Nelson-Maney, Paul A. Monach, Pierre Cunin, Anaïs Levescot, Giuseppina Stifano, Brinda Vijaykumar, Ricardo Grieshaber-Bouyer, Rachel B Blaustein
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete neutrophil subsets is not known. Here, we apply single-cell RNA sequencing to neutrophils from normal and inflamed mouse
Autor:
Alsya J. Affandi, Tiago Carvalheiro, Andrea Ottria, Judith J. de Haan, Maike A.D. Brans, Maarten M. Brandt, Ralph G. Tieland, Ana P. Lopes, Beatriz Malvar Fernández, Cornelis P.J. Bekker, Maarten van der Linden, Maili Zimmermann, Barbara Giovannone, Catharina G.K. Wichers, Samuel Garcia, Michael de Kok, Giuseppina Stifano, Yan Juan Xu, M. Anna Kowalska, Maaike Waasdorp, Caroline Cheng, Susan Gibbs, Saskia C.A. de Jager, Joel A.G. van Roon, Timothy R.D.J. Radstake, Wioleta Marut
Publikováno v:
Cell Reports, 38(1):110189. Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernandez, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Cell Reports, 38(1). Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernández, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernandez, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Cell Reports, 38(1). Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernández, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic disease in which CXCL4 is increased and strongly correlates with sk
Autor:
Robert W. Simms, Julio C. Mantero, Jessica Ziemek, Jessica K. Gordon, Giuseppina Stifano, Robert Lafyatis, Robyn T. Domsic, Lisa M. Rice
Publikováno v:
Journal of Investigative Dermatology. 137:62-70
In this study we systematically investigated alterations in the serum proteome of patients with diffuse cutaneous systemic sclerosis and identified differentially expressed proteins that correlated with disease severity. Our goal was to identify a co
Autor:
Bashar Kahaleh, Tracy Tabib, Sokratis A. Apostolidis, Robert Lafyatis, Lisa M. Rice, Christina Morse, Giuseppina Stifano
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
Objective: The mechanisms that lead to endothelial cell (EC) injury and propagate the vasculopathy in Systemic Sclerosis (SSc) are not well understood. Using single cell RNA sequencing (scRNA-seq), our goal was to identify EC markers and signature pa
Autor:
Julio C, Mantero, Nina, Kishore, Jessica, Ziemek, Giuseppina, Stifano, Christopher, Zammitti, Dinesh, Khanna, Jessica K, Gordon, Robert, Spiera, Yuqing, Zhang, Robert W, Simms, Robert, Lafyatis
Publikováno v:
Clinical and experimental rheumatology. 36(4)
This clinical trial was designed to study the safety and efficacy of blocking IL-1 in skin fibrosis of patients with diffuse cutaneous systemic sclerosis (dcSSc), and to test the hypothesis that inhibition of IL-1 by rilonacept will downregulate expr
Autor:
Jessica K. Gordon, Allison L. Mathes, Robert W. Simms, Michael L. Whitfield, Romy B. Christmann, Yuqing Zhang, Jessica Ziemek, Eric A. Stratton, Giuseppina Stifano, Sarah R. McLaughlin, Robert Lafyatis, Robert Spiera, Cristina Padilla, Jeffrey L. Browning, Lisa M. Rice
Publikováno v:
Arthritis & Rheumatology. 67:3004-3015
Objective To define a pharmacodynamic biomarker based on gene expression in skin that would provide a biologic measure of the extent of disease in patients with diffuse cutaneous systemic sclerosis (dcSSc) and could be used to monitor skin disease lo