Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Giuseppina Palladini"'
Autor:
Giuseppina Palladini, Laura Giuseppina Di Pasqua, Anna Cleta Croce, Andrea Ferrigno, Mariapia Vairetti
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17407 (2023)
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored glycoprotein, negatively regulates various membrane proteins involved in the tissue governing extracellular matrix (ECM) remodeling such as metalloproteases (M
Externí odkaz:
https://doaj.org/article/f7ec502f96bb470b95604a8f3231b30b
Autor:
Anna C. Croce, Andrea Ferrigno, Giuseppina Palladini, Barbara Mannucci, Mariapia Vairetti, Laura G. Di Pasqua
Publikováno v:
Molecules, Vol 28, Iss 9, p 3818 (2023)
The autofluorescence of specific fatty acids, retinoids, and bilirubin in crude serum can reflect changes in liver functional engagement in maintaining systemic metabolic homeostasis. The role of these fluorophores as intrinsic biomarkers of pharmaco
Externí odkaz:
https://doaj.org/article/7416e569fc0a4d9dbb07fdf01b8a233a
Autor:
Giuseppina Palladini, Laura Giuseppina Di Pasqua, Marta Cagna, Anna Cleta Croce, Stefano Perlini, Barbara Mannucci, Antonella Profumo, Andrea Ferrigno, Mariapia Vairetti
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6817 (2022)
We evaluate the effects of the methionine-choline-deficient (MCD) diet on serum and hepatic zinc (Zn) and iron (Fe) and their relationships with matrix metalloproteinases (MMPs) and their modulators (TIMPs and RECK) as well as hepatic fatty acids usi
Externí odkaz:
https://doaj.org/article/4e8485e7ad4c4fa99df23d022a5e388b
Autor:
Giuseppina Palladini, Marta Cagna, Laura Giuseppina Di Pasqua, Luciano Adorini, Anna Cleta Croce, Stefano Perlini, Andrea Ferrigno, Clarissa Berardo, Mariapia Vairetti
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 524 (2022)
We have previously demonstrated that the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) protects the liver via downregulation of hepatic matrix metalloproteinases (MMPs) after ischemia/reperfusion (I/R), which can lead to multiorgan dysfun
Externí odkaz:
https://doaj.org/article/d19198b40c604ad184f40f87acaf108c
Autor:
Andrea Ferrigno, Giuseppina Palladini, Laura Giuseppina Di Pasqua, Clarissa Berardo, Plinio Richelmi, Massimiliano Cadamuro, Luca Fabris, Stefano Perlini, Luciano Adorini, Mariapia Vairetti
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238543 (2020)
BackgroundWe have previously shown that obeticholic acid (OCA) upregulates the biliary excretion of asymmetric dimethylarginine (ADMA), an inhibitor of iNOS regulating the activity of matrix metalloproteinases (MMPs). Here, the effects of OCA on MMP-
Externí odkaz:
https://doaj.org/article/4c4386cfadfc46f9ac6419c8fc9d4d96
Autor:
Giuseppina Palladini, Andrea Ferrigno, Laura Giuseppina Di Pasqua, Clarissa Berardo, Vittoria Rizzo, Stefano Perlini, Mariapia Vairetti
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243179 (2020)
BackgroundThe comparison of hepatic steatosis animal models has allowed the understanding of mechanisms involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the progression to nonalcoholic steatohepatitis (NASH). We investiga
Externí odkaz:
https://doaj.org/article/ecf04127f52e46709cf803036ccfcbba
Autor:
Giuseppina Palladini, Laura G. Di Pasqua, Clarissa Berardo, Veronica Siciliano, Plinio Richelmi, Stefano Perlini, Andrea Ferrigno, Mariapia Vairetti
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2019 (2019)
Animal models of obstructive cholestasis and ischemia/reperfusion damage have revealed the functional heterogeneity of liver lobes. This study evaluates this heterogeneity in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (
Externí odkaz:
https://doaj.org/article/a7c155c29c894c2cad6dbe004426f2bc
Autor:
Andrea Ferrigno, Laura G. Di Pasqua, Giuseppina Palladini, Clarissa Berardo, Roberta Verta, Plinio Richelmi, Stefano Perlini, Debora Collotta, Massimo Collino, Mariapia Vairetti
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 747 (2020)
In this study, we demonstrated the involvement of matrix metalloproteinases (MMPs) in hepatic ischemia/reperfusion (I/R) injury. Our aim is to evaluate the impact of reperfusion on I/R-related changes in RECK, an MMP modulator, and mitogen-activated
Externí odkaz:
https://doaj.org/article/dcf9ce183aca471bae570e4faccd4759
Autor:
Giuseppina Palladini, Laura G. Di Pasqua, Clarissa Berardo, Veronica Siciliano, Plinio Richelmi, Barbara Mannucci, Anna Cleta Croce, Vittoria Rizzo, Stefano Perlini, Mariapia Vairetti, Andrea Ferrigno
Publikováno v:
Nutrients, Vol 11, Iss 4, p 799 (2019)
We investigated changes in fatty acid desaturases, D5D, D6D, D9-16D and D9-18D, and their relationship with oxidative stress, matrix metalloproteinases (MMPs) and serum TNF-alpha in two rat models of non-alcoholic fatty liver disease NAFLD. Eight-wee
Externí odkaz:
https://doaj.org/article/1d632e8df19a40b8bfcb643b9d91a0a7
Autor:
Giuseppina Palladini, Andrea Ferrigno, Vittoria Rizzo, Eleonora Tarantola, Vittorio Bertone, Isabel Freitas, Stefano Perlini, Plinio Richelmi, Mariapia Vairetti
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Purpose. Warm hepatic ischemia-reperfusion (I/R) injury can lead to multiorgan dysfunction. The aim of the present study was to investigate whether acute liver I/R does affect the function and/or structure of remote organs such as lung, kidney, and h
Externí odkaz:
https://doaj.org/article/6fa87597326e451eb833a44b7fd991cf